Interferon-β
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Reactions 595 - 6 Apr 1996 Interferon-β Cutaneous ulcerations and exacerbation of psoriasis: 8 case reports Eight patients with multiple sclerosis received SC injections with recombinant interferon-β [‘Betaseron’] 32 × 10 6 IU/day. Six patients developed ulcerations at the injection sites, 1 patient had painful nodules that did not ulcerate, and 1 patient experienced a pustular flare of her usually quiescent psoriasis. The onset of the patients’ symptoms occurred 6–19 weeks after beginning interferon-β. All 7 patients with injection site reactions experienced pain after the injection, and 2 patients experienced severe pruritus. Interferon-β therapy was discontinued when the reactions were reported. However, 1 patient did continue interferon-β therapy without any further problems. The ulcerations were sharply bordered and initially there was an overlying black eschar. The results of biopsy specimens showed a mixed perivascular infiltrate. All of the ulcers healed with routine wound care, and the older lesions showed evidence of scarring. No evidence of an infectious cause for the skin disorders was found. Webster GF, et al. Cutaneous ulcerations and pustular psoriasis flare caused by recombinant interferon beta injections in patients with multiple sclerosis. Journal of the American Academy of Dermatology 34: 365-367, Part 2, Feb 1996 - USA 800424722 » Editorial comment: A search of Medline and AdisBase revealed only 1 report of psoriasis induced at the injection site of interferon-β. 1 Reactions 6 Apr 1996 No. 595 0114-9954/10/0595-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Interferon-β
Reactions 595 - 6 Apr 1996
Interferon-βCutaneous ulcerations and exacerbation ofpsoriasis: 8 case reports
Eight patients with multiple sclerosis received SC injectionswith recombinant interferon-β [‘Betaseron’] 32 × 106 IU/day.Six patients developed ulcerations at the injection sites, 1patient had painful nodules that did not ulcerate, and 1 patientexperienced a pustular flare of her usually quiescent psoriasis.
The onset of the patients’ symptoms occurred 6–19 weeksafter beginning interferon-β. All 7 patients with injection sitereactions experienced pain after the injection, and 2 patientsexperienced severe pruritus. Interferon-β therapy wasdiscontinued when the reactions were reported. However, 1patient did continue interferon-β therapy without any furtherproblems.
The ulcerations were sharply bordered and initially therewas an overlying black eschar. The results of biopsy specimensshowed a mixed perivascular infiltrate. All of the ulcers healedwith routine wound care, and the older lesions showedevidence of scarring. No evidence of an infectious cause for theskin disorders was found.Webster GF, et al. Cutaneous ulcerations and pustular psoriasis flare caused byrecombinant interferon beta injections in patients with multiple sclerosis. Journal ofthe American Academy of Dermatology 34: 365-367, Part 2, Feb 1996 -USA 800424722
» Editorial comment: A search of Medline and AdisBaserevealed only 1 report of psoriasis induced at the injection siteof interferon-β.
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Reactions 6 Apr 1996 No. 5950114-9954/10/0595-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
