ChemInform Abstract: Regiospecific Synthesis of 4-(2-Oxoalkyl)pyridines.
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2002 pyridine derivatives pyridine derivatives R 0380 02 - 156 Regiospecific Synthesis of 4-(2-Oxoalkyl)pyridines. — A new method for the regioselective introduction of β-oxoalkyl groups into the 4-position of pyridine is presented. Title compounds (V) are prepared in two steps via dihydropyridines (IV). In the first step, triflic anhydride is used to activate the pyridine ring to react with ketones (I). In the second step, under treatment of the dihydropyridines with tBuOK in DMSO, the triflate group is eliminated. This method complements the existing methods as it is highly regioselective and high-yielding. — (KATRITZKY, ALAN R.; ZHANG, SUOMING; KURZ, THOMAS; WANG, MINGYI; STEEL, PETER J.; Org. Lett. 3 (2001) 18, 2807-2809; Dep. Chem., Cent. Heterocycl. Compd., Univ. Fla., Gainesville, FL 32611, USA; EN) 1
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Transcript of ChemInform Abstract: Regiospecific Synthesis of 4-(2-Oxoalkyl)pyridines.
2002 pyridine derivatives
pyridine derivativesR 0380
02 - 156Regiospecific Synthesis of 4-(2-Oxoalkyl)pyridines. — A new methodfor the regioselective introduction of β-oxoalkyl groups into the 4-position ofpyridine is presented. Title compounds (V) are prepared in two steps viadihydropyridines (IV). In the first step, triflic anhydride is used to activate thepyridine ring to react with ketones (I). In the second step, under treatment ofthe dihydropyridines with tBuOK in DMSO, the triflate group is eliminated.This method complements the existing methods as it is highly regioselectiveand high-yielding. — (KATRITZKY, ALAN R.; ZHANG, SUOMING; KURZ,THOMAS; WANG, MINGYI; STEEL, PETER J.; Org. Lett. 3 (2001) 18,2807-2809; Dep. Chem., Cent. Heterocycl. Compd., Univ. Fla., Gainesville, FL32611, USA; EN)
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