ChemInform Abstract: Epoxide Ring Opening of α,β-Epoxysilanes with Prop-2-ynyl Sulfide Dianion -...

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1997 hormones hormones U 1000 27 - 260 Epoxide Ring Opening of α,β-Epoxysilanes with Prop-2-ynyl Sulfide Dianion - Synthesis of (11R,12S,5Z,7E,9E,14Z)-Dihydroxyeicosa- 5,7,9,14-tetraenoic Acid. A new methodology for the stereoselective synthesis of vicinal diols such as (III) is developed using the tert-butyl sulfide (II) as the reagent of choice. (III) is used for the preparation of the title compound (VI). — (KOBAYASHI, Y.; SHIMIZU, K.; SATO, F.; Chem. Commun. (Cambridge) (1997) 5, 493-494; Dep. Biomol. Eng., Tokyo Inst. Technol., Midori, Yokohama 226, Japan; EN) 1

Transcript of ChemInform Abstract: Epoxide Ring Opening of α,β-Epoxysilanes with Prop-2-ynyl Sulfide Dianion -...

Page 1: ChemInform Abstract: Epoxide Ring Opening of α,β-Epoxysilanes with Prop-2-ynyl Sulfide Dianion - Synthesis of (11R,12S,5Z,7E,9E,14Z)-Dihydroxyeicosa- 5,7,9,14-tetraenoic Acid.

1997 hormones

hormonesU 1000

27 - 260Epoxide Ring Opening of α,β-Epoxysilanes with Prop-2-ynyl SulfideDianion - Synthesis of (11R,12S,5Z,7E,9E,14Z)-Dihydroxyeicosa-5,7,9,14-tetraenoic Acid. — A new methodology for the stereoselectivesynthesis of vicinal diols such as (III) is developed using the tert-butyl sulfide(II) as the reagent of choice. (III) is used for the preparation of the titlecompound (VI). — (KOBAYASHI, Y.; SHIMIZU, K.; SATO, F.; Chem.Commun. (Cambridge) (1997) 5, 493-494; Dep. Biomol. Eng., Tokyo Inst.Technol., Midori, Yokohama 226, Japan; EN)

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