PPARPeroxisome proliferator-activated receptors

PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptorsuperfamily comprising of the following three subtypes PPARα PPARγ and PPARβδ PPARs play essential roles in the regulationof cellular differentiation development and metabolism (carbohydrate lipid protein) and tumorigenesis of higher organisms AllPPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes Activation ofPPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis Activation of PPAR-γ enhances glucosemetabolism whereas activation of PPAR-βδ enhances fatty acids metabolism

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PPAR Inhibitors Agonists Antagonists Activators amp Modulators

13-Oxo-9E11E-octadecadienoic acidCat No HY-N5097

13-Oxo-9E11E-octadecadienoic acid an isomer of9-oxo-ODA is a potent activator derivedPPARαfrom tomato juice 13-Oxo-9E11E-octadecadienoicacid decreases plasma and hepatic triglyceride inobese diabetic mice

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

15-Deoxy-Δ-1214-prostaglandin J2 (15d-PGJ2 15-Deoxy-Δ1214-PGJ2) Cat No HY-108568

15-Deoxy-Δ-1214-prostaglandin J2 (15d-PGJ2) is acyclopentenone prostaglandin and a metabolite ofPGD2 15-Deoxy-Δ-1214-prostaglandin J2 is aselective ( of 2 microM) and a covalentPPARγ EC50

agonistPPARδ

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

4-O-Methyl honokiolCat No HY-U00450

4-O-Methyl honokiol is a natural neolignanisolated from acts as aMagnolia officinalis

agonist and inhibtis activity usedPPARγ NF-κBfor cancer and inflammation research

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

5-Aminosalicylic Acid (Mesalamine 5-ASA Mesalazine) Cat No HY-15027

5-Aminosalicylic acid (Mesalamine) acts as aspecific agonist and also inhibitsPPARγp21-activated kinase 1 ( ) and PAK1 NF-κB

Purity gt980Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 10 g

AdelmidrolCat No HY-B1026

Adelmidrol exerts important anti-inflammatoryeffects that are partly dependent on PPARγAdelmidrol reduces translocation andNF-κB

expressionCOX-2

Purity gt980Clinical Data Phase 3Size 10 mM times 1 mL 100 mg

Agrimol BCat No HY-N0704

Agrimol B is a polyphenol derived from suppresses adipogenesisAgrimonia pilosa Ledeb

via inducing translocation and expressionSIRT1and reducing expressionPPARγ

Purity 9936Clinical Data No Development ReportedSize 5 mg 10 mg

Aleglitazar (R1439 RO0728804) Cat No HY-14728

Aleglitazar(R1439 RO-0728804) is a new dualPPAR-αγ agonist with IC50 of 28 nM46 nM

Purity 9930Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

AlpinetinCat No HY-N0625A

Alpinetin is a flavonoid isolated from Alpinia activates activates katsumadai Hayata PPAR-γ

with potent anti-inflammatory activity

Purity 9907Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 20 mg

Angeloylgomisin HCat No HY-N2209

Angeloylgomisin H as a major lignin extract of has the potential to improveSchisandra rubriflora

insulin-stimulated glucose uptake by activatingPPAR-γ

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg

AnkaflavinCat No HY-N6642

Ankaflavin isolated from Monascus-Fermented redrice is a agonist with anti-inlfammatoryPPARγactivity Ankaflavin exhibits selective cytotoxiceffect and induces cell death on cancer cells

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

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Arhalofenate (MBX 102 JNJ 39659100) Cat No HY-14831

Arhalofenate (MBX 102) is a selective partialagonist of peroxisome proliferator-activatedreceptor used for the treatment of type(PPAR)-γ2 diabetes

Purity gt98Clinical Data Phase 2Size 1 mg 5 mg

AstaxanthinCat No HY-B2163

Astaxanthin a red dietary carotenoid isolatedfrom is a modulator ofHaematococcus pluvialis

and a potent antioxidant withPPARγantiproliferative neuroprotective andanti-inflammatory activity

Purity gt980Clinical Data LaunchedSize 5 mg 10 mg

AVE-8134Cat No HY-U00014

AVE-8134 is a potent agonist with PPARα EC50

values of 100 and 3000 nM for human and rodentPPARα receptor respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Balaglitazone (DRF 2593 NN 2344) Cat No HY-16086

Balaglitazone is a selective partial PPARγagonist with an of 1351 μM for humanEC50

PPARγ

Purity 9921Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Bezafibrate (BM15075) Cat No HY-B0637

Bezafibrate is an agonist of with sPPAR EC50

of 50 μM 60 μM 20 μM for human PPARα PPARγand and 90 μM 55 μM 110 μM for PPARδ murine

and respectivelyPPARα PPARγ PPARδBezafibrate is used as an hypolipidemic agent

Purity 9943Clinical Data LaunchedSize 10 mM times 1 mL 100 mg

BilobetinCat No HY-N2118

Bilobetin an active component of canGinkgo bilobareduce blood lipids and improve the effects ofinsulin

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg

BMS-687453Cat No HY-10678

BMS-687453 is a potent and selective PPARαagonist with an and of 10 nM and 260EC50 IC50

nM for human and 4100 nM and gt15000 nMPPARαfor PPARγ in PPAR-GAL4 transactivation assays

Purity 9904Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

CDDO-Im (RTA-403 TP-235 CDDO-Imidazolide) Cat No HY-15725

CDDO-Im (CDDO-imidazolide) is an activator of and with s of 232 and 344 nM forNrf2 PPAR Ki

PPARα and PPARγ

Purity 9820Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

Cefminox sodium (MT-141) Cat No HY-128932

Cefminox sodium (MT-141) is a semisyntheticcephamycin which exhibits a broad spectrum of

activityantibacterial

Purity gt98Clinical Data LaunchedSize 1 mg 5 mg

ChiglitazarCat No HY-106266

Chiglitazar is a dual agonist withPPARαγ of 12 008 17 μM for PPARα PPARγ andEC s50

PPARδ respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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Choline Fenofibrate (ABT-335) Cat No HY-14739

Choline Fenofibrate (ABT-335) is the choline saltof fenofibric acid under clinical development as acombination therapy with rosuvastatin for themanagement of dyslipidemia

Purity 9993Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 100 mg

Cinnamyl AlcoholCat No HY-Y0078

Cinnamyl Alcohol is an active component fromchestnut flower inhibits increased PPARγexpression with anti-obesity activity

Purity gt980Clinical Data No Development ReportedSize 5 mg

Ciprofibrate (Win35833) Cat No HY-B0664

Ciprofibrate is a peroxisomeproliferator-activated receptor agonist

Purity 9979Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Ciprofibrate D6Cat No HY-B0664S

Ciprofibrate D6 is deuterium labeled Ciprofibratewhich is a peroxisome proliferator-activatedreceptor agonist

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

ClofibrateCat No HY-B0287

Clofibrate is an agonist of with s ofPPAR EC50

50 μM 500 μM for murine PPARα and PPARγ and 55μM 500 μM for human PPARα and PPARγrespectively

Purity 9959Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

ConvallatoxinCat No HY-N2453

Convallatoxin is a cardiac glycoside isolated from ConvallatoxinAdonis amurensis Regel et Radde

ameliorates colitic inflammation via activation of and suppression of PPARγ NF-κB

Purity gt98Clinical Data No Development ReportedSize 5 mg 25 mg 50 mg

CUDACat No HY-121538

CUDA is a potent inhibitor of soluble epoxide with s of 111 nM and 112 nMhydrolase (sEH) IC50

for mouse sEH and human sEH respectively CUDAselectively increases peroxisomeproliferator-activated receptor (PPAR) alphaactivity

Purity gt980Clinical Data No Development ReportedSize 5 mg 10 mg

DaidzeinCat No HY-N0019

Daidzein is a soy isoflavone which acts as a activatorPPAR

Purity 9966Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g 10 g

DG172 dihydrochlorideCat No HY-19737A

DG172 dihydrochloride is a selective PPARβδantagonist with an of 27 nMIC50

Purity 9970Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Eicosatetraynoic acid (ETYA) Cat No HY-124108

Eicosatetraynoic acid (ETYA) is a nonspecificinhibitor of and ( =8cyclooxygenase lipoxygenase ID50

μM and 4 μM respectively) Eicosatetraynoic acid(ETYA) activates PPARα and PPARγ chimeras at 10microM

Purity gt98Clinical DataSize 1 mg

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Elafibranor (GFT505) Cat No HY-16737

Elafibranor (GFT505) is a agonist withPPARαδs of 45 and 175 nM respectivelyEC50

Purity 9918Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg

Ertiprotafib (PTP 112) Cat No HY-19383

Ertiprotafib is an inhibitor of PTP1B IkB kinase and a dual agonistβ (IKK-β) PPARα and PPARβ

with an of 16 μM for PTP1B 400 nM forIC50

IKK-β an of ~1 μM for PPARαPPARβEC50

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

EupatilinCat No HY-N0783

Eupatilin a lipophilic flavonoid isolated from species is a agonist andArtemisia PPARα

possesses anti-apoptotic anti-oxidative andanti-inflammatory activities

Purity 9901Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg

FenofibrateCat No HY-17356

Fenofibrate is a selective agonist with anPPARα of 30 μM Fenofibrate also inhibits humanEC50

cytochrome P450 isoforms with s of 02 07IC50

97 48 and 1421 μM for CYP2C19 CYP2B6 and respectivelyCYP2C9 CYP2C8 CYP3A4

Purity 9992Clinical Data LaunchedSize 200 mg 5 g 10 g

Fenofibric acid (FNF acid) Cat No HY-B0760

Fenofibric acid an active metabolite offenofibrate is a activitor with s ofPPAR EC50

224 microM 147 microM and 106 microM for PPARα PPARγ andPPARδ respectively Fenofibric acid also inhibits

enzyme activity with an of 48 nMCOX-2 IC50

Purity 9967Clinical Data LaunchedSize 10 mM times 1 mL 500 mg 1 g 5 g

FH535Cat No HY-15721

FH535 is an inhibitor of andWntβ-catenin with anti-tumor activitiesPPAR

Purity 9993Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

FisetinCat No HY-N0182

Fisetin is a natural flavonol found in many fruitsand vegetables with various benefits such asantioxidant anticancer neuroprotection effects

Purity 9802Clinical Data Phase 2Size 10 mM times 1 mL 100 mg 500 mg 1 g

Fonadelpar (NPS-005 SJP-0035) Cat No HY-17633

Fonadelpar is a agonist used in thePPARδresearch of neuroparalytic keratopathy

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Gemfibrozil (CI-719) Cat No HY-B0258

Gemfibrozil is an activator of used as aPPAR-αlipid-lowering drug Gemfibrozil is also anonselective inhibitor of several isoformsP450with values for CYP2C9 2C19 2C8 and 1A2 ofKi

58 24 69 and 82 μM respectively

Purity 9991Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Gemfibrozil 1-O-β-glucuronideCat No HY-129993

Gemfibrozil 1-O-β-Glucuronide a metabolite ofGemfibrozil (CI-719 HY-B0258) is a potent andcompetitive isoform CYP2C8 inhibitorP450 (CYP)with an of 407 μMIC50

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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Ginsenoside Rh1 (Prosapogenin A2 Sanchinoside B2 Sanchinoside Rh1) Cat No HY-N0604

Ginsenoside Rh1 (Prosapogenin A2 Sanchinoside B2Sanchinoside Rh1) is isolated from the root of

Ginsenoside Rh1 inhibits thePanax Ginsengexpression of and PPAR-γ TNF-α IL-6 IL-1β

Purity gt980Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg

GlabridinCat No HY-N0393

Glabridin is a natural isoflavan from Glycyrrhiza binds to and activates with anglabra PPARγ

of 6115 nMEC50

Purity 9998Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg

GlabroneCat No HY-N4194

Glabrone is an isoflavone isolated from Glycyrrhiza roots Glabrone exhibits anti-influenzaglabra

activity and significant PPAR-γ ligand-bindingactivity

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

GSK0660Cat No HY-12377

GSK0660 is a potent antagonist of andPPARβ with s of 155 nM for both isoformsPPARδ IC50

Purity 9959Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

GSK376501ACat No HY-101746

GSK376501A is a selective peroxisomeproliferator-activated receptor gamma ( )PPARγmodulator for the treatment of type 2 diabetesmellitus

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

GSK3787Cat No HY-15577

GSK3787 is a selective and irreversible peroxisomeproliferator-activated receptor δ ( )PPARδantagonist with of 66pIC50

Purity 9667Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg

GW 501516 (GW 1516 GSK-516) Cat No HY-10838

GW 501516 is a agonist with an ofPPARδ EC50

11 nM

Purity 9927Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

GW 6471Cat No HY-15372

GW 6471 is a potent antagonistPPARα

Purity 9898Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

GW0742 (GW610742) Cat No HY-13928

GW0742 is a potent and agonist withPPARβ PPARδan of 1 nM for human in binding assayIC50 PPARδand s of 1 nM 11 μM and 2 μM for humanEC50

PPARα and PPARγ respectivelyPPARδ

Purity 9727Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

GW1929Cat No HY-15655

GW1929 is a potent agonist with a ofPPAR-γ pKi

884 for human and s of 856 andPPAR-γ pEC50

827 for human and murine PPAR-γ PPAR-γrespectively

Purity 9964Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg

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GW7647Cat No HY-13861

GW7647 is a potent agonist with s ofPPARα EC50

6 nM 11 μM and 62 μM for human PPARα PPARγand PPARδ respectively

Purity 9804Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

GW9662Cat No HY-16578

GW9662 is a potent and selective antagonistPPARγwith an of 33 nM showing 10 and 1000-foldIC50

selectivity over PPARα and PPARδ respectively

Purity 9983Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

Gypenoside XLIXCat No HY-N1990

Gypenoside XLIX a dammarane-type glycoside is aprominent component of G pentaphyllum

Purity gt990Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg

Icariin (Ieariline) Cat No HY-N0014

Icariin is a flavonol glycoside Icariin inhibits and activities with s of 432 nMPDE5 PDE4 IC50

and 7350 μM respectively Icariin also is a activatorPPARα

Purity 9875Clinical Data Phase 3Size 10 mM times 1 mL 100 mg 200 mg 500 mg

Imiglitazar (TAK-559) Cat No HY-101649

Imiglitazar (TAK559) is a potent and dual human and agonist with values ofPPARα PPARγ1 EC50

67 and 31 nM

Purity gt98Clinical Data Phase 3Size 1 mg 5 mg

Indeglitazar (PPM 204) Cat No HY-14817

Indeglitazar (PPM 204) is an orally available pan-agonist for all three PPARα PPARδ andPPAR

PPARγ

Purity 9942Clinical Data Phase 2Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

Inolitazone (Efatutazone CS-7017 RS5444) Cat No HY-14792

Inolitazone a novel high-affinity agonistPPARγthat is dependent upon PPARγ for its biologicalactivity with of 08 nM for growthIC50

inhibition

Purity gt98Clinical Data Phase 2Size 1 mg 5 mg

Inolitazone dihydrochloride (Efatutazone dihydrochloride

CS-7017 dihydrochloride RS5444 dihydrochloride) Cat No HY-14792B

Inolitazone dihydrochloride (Efatutazonedihydrochloride) is a novel high-affinity PPARγagonist that is dependent upon PPARγ for itsbiological activity with of 08 nM for growthIC50

inhibition

Purity 9921Clinical Data Phase 2Size 10 mM times 1 mL 5 mg

iRucaparib-AP6Cat No HY-130644

iRucaparib-AP6 is a highly efficient and specific degrader based on Rucaparib by using thePARP1

PROTAC approach iRucaparib-AP6 a non-trappingPARP1 degrader blocks both the catalytic activityand scaffolding effects of PARP1

Purity 9806Clinical Data No Development ReportedSize 1 mg 5 mg 10 mg

KD-3010Cat No HY-111068

KD-3010 is a potent orally active and selective agonistPPARδ

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

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L-165041Cat No HY-20019

L-165041 is a cell permeable agonist withPPARδs of 6 nM and appr 730 nM for PPARδ and PPARγKi

respectively and induces adipocytedifferentiation in NIH-PPARδ cells

Purity 9974Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Lanifibranor (IVA337) Cat No HY-104049

Lanifibranor is a pan peroxisome ( ) agonistproliferator-activated receptor PPAR

with s of 15 087 and 021 μM for humanEC50

and respectivelyPPARα PPARσ PPARγ

Purity 9889Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

Leriglitazone (Hydroxypioglitazone) Cat No HY-117727

Leriglitazone (Hydroxypioglitazone) a metaboliteof pioglitazone

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Licarin B ((-)-Licarin B) Cat No HY-N0479

Licarin B a nitric oxide production inhibitorextracted from the component of the seeds of

improves insulin sensitivityMyristica fragransvia and activation of GLUT4 in thePPARγIRS-1PI3KAKT pathway

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

LJ570Cat No HY-111775

LJ570 is a dual agonist with sPPARα PPARγ EC50

of 105 and 012 μM respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

LY518674 (LY-674) Cat No HY-50665

LY518674 is a potent selective antagonistPPARαwith an of 42 nM for human PPARα LY518674EC50

reduces triglycerides in and increased HDL-C andis used for the treatment of atherosclerosis

Purity 9915Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg

MA-0204Cat No HY-114739

MA-0204 is a potent highly selective and orallyavailable peroxisome proliferator activatedreceptor δ ( ) modulator with s of 04PPARδ EC50

nM 79 nM and 10 nM for human mouse and ratPPARδ respectively Potential treatment forDuchene Muscular Dystrophy (DMD)

Purity 9971Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

MagnololCat No HY-N0163

Magnolol a natural lignan isolated from the stembark of is a dual agonistMagnolia officinalisof both and with values ofRXRα PPARγ EC50

104 microM and 177 microM respectively

Purity 9972Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

Mifobate (SR-202) Cat No HY-100277

Mifobate (SR-202) is a potent and specific PPARγantagonist Mifobate (SR-202) selectively inhibitsThiazolidinedione (TZD)-induced PPARγtranscriptional activity ( =140 μM)IC50

Purity gt990Clinical Data No Development ReportedSize 10 mM times 1 mL 1 mg 5 mg

MK-886 (L 663536) Cat No HY-14166

MK-886 (L 663536) is a potent cell-permeable andorally active ( of 30 nM) and FLAP IC50 leukotriene

( s of 3 nM and 11 μM in intactbiosynthesis IC50

leukocytes and human whole blood respectively)inhibitor MK-886 is also a non-competitive PPARαantagonist and can induce apoptosis

Purity 9977Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

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NaringeninCat No HY-N0100

Naringenin is the predominant flavanone ingrapefruit displays strong anti-inflammatory andantioxidant activities Naringenin has anti-dengue

activityvirus (DENV)

Purity 9872Clinical Data Phase 1Size 10 mM times 1 mL 100 mg 500 mg 1 g 5 g

Naveglitazar (LY519818) Cat No HY-U00036A

Naveglitazar (LY519818) is a nonthiozolidinedioneperoxisome proliferator-activated receptor ( )PPARα-γ dual γ-dominant agonist that has shownglucose-lowering potential in animal models

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Naveglitazar racemate (LY519818 racemate) Cat No HY-U00036

Naveglitazar racemate (LY519818 racemate) is theracemate of Naveglitazar Naveglitazar is anonthiozolidinedione peroxisomeproliferator-activated receptor ( ) α-γ dualPPARγ-dominant agonist that has shown glucose-loweringpotential in animal models

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

NXT629Cat No HY-114263

NXT629 is a potent selective and competitive antagonist with an of 77 nM forPPAR-α IC50

human PPARα shows high selectivity over othernuclear hormone receptor such as PPARδ PPARγERβ GR and TRβ s are 60 15 152 325 andIC50

gt100 μM respectively

Purity 9905Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

Oleoylethanolamide (N-Oleoylethanolamide Oleamide MEA Oleic

acid monoethanolamide) Cat No HY-107542

Oleoylethanolamide is a high affinity endogenous agonist which plays an important role inPPAR-α

the treatment of obesity and arteriosclerosis

Purity 9955Clinical DataSize 10 mM times 1 mL 5 mg 10 mg

OleuropeinCat No HY-N0292

Oleuropein found in olive leaves and oil exertsantioxidant anti-inflammatory andanti-atherogenic effects through direct inhibitionof transcriptional activityPPARγ

Purity 9854Clinical Data No Development ReportedSize 5 mg 10 mg 20 mg

Ophiopogonin DCat No HY-N0515

Ophiopogonin D isolated from the tubers of is a rare naturally occurringOphiopogon japonicus

C steroidal glycoside29

Purity gt98Clinical Data No Development ReportedSize 5 mg 10 mg 25 mg

Palmitelaidic Acid (9-trans-Hexadecenoic acid trans-Palmitoleic acid) Cat No HY-N2341

Palmitelaidic Acid (9-trans-Hexadecenoic acid) isthe trans isomer of palmitoleic acid Palmitoleicacid is one of the most abundant fatty acids inserum and tissue

Purity gt990Clinical Data No Development ReportedSize 10 mg (393 mM 100 μL in Ethanol)

Peliglitazar racemate (BMS 426707-01 racemate) Cat No HY-101738A

Peliglitazar racemate is the racemate ofPeliglitazar Peliglitazar is a novel dual αγPPAR activator

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pioglitazone (U 72107) Cat No HY-13956

Pioglitazone (U 72107) is a potent and selective agonist with high affinity binding to thePPARγ

PPARγ ligand-binding domain with of 093EC50

and 099 μM for human and mouse PPARγrespectively

Purity 9918Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg

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Pioglitazone D4 (U 72107 D4) Cat No HY-13956S

Pioglitazone D4 (U 72107 D4) is a deuteriumlabeled Pioglitazone Pioglitazone (U 72107) is apotent and selective agonist with highPPARγaffinity binding to the PPARγ ligand-bindingdomain with of 093 and 099 μM for humanEC50

and mouse PPARγ respectively

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pioglitazone hydrochloride (U 72107A AD 4833) Cat No HY-14601

Pioglitazone hydrochloride is a potent andselective agonist with s of 093 andPPARγ EC50

099 μM for human and mouse PPARγ respectively

Purity 9639Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg

Pirinixic acid (Wy-14643) Cat No HY-16995

Pirinixic acid (Wy-14643) is a potent agonist of with s of 063 μM 32 μM for murinePPARα EC50

and PPARγ and 50 μM 60 μM 35 μM forPPARαhuman PPARγ and PPARδ respectivelyPPARα

Purity 9948Clinical Data No Development ReportedSize 10 mM times 1 mL 10 mg 50 mg 100 mg 250 mg

PPAR agonist 1Cat No HY-U00340

PPAR agonist 1 is an agonist of and PPAR α PPAR used for reducing blood glucose lipid levelsγ

lowering cholesterol and reducing body weight

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

PPARα-MO-1Cat No HY-U00068

PPARα-MO-1 is a potent modulator extractedPPARαfrom patent WO2004110982A1 formula I

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pparδ agonistCat No HY-112597

PPARδ agonist is a agonist extracted fromPPARδpatent US20180071304 compound example 10

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pparδ agonist 1Cat No HY-107901

Pparδ agonist 1 is a agonist with anPPAR-δ of 506 nM used in the research ofEC50

PPAR-delta related diseases such as mitochondrialdiseases muscular diseases vascular diseasesdemyelinating diseases and metabolic diseases

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Pparδ agonist 2Cat No HY-100120

Pparδ agonist 2 is a agonist extracted fromPPARδpatent WO 2016057656 A1

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Raspberry ketone (Frambione 4-(4-Hydroxyphenyl)-2-butanone) Cat No HY-N1426

Raspberry ketone is a major aromatic compound ofred raspberry widely used as a fragrance incosmetics and as a flavoring agent in foodstuffalso shows agonistic activityPPAR-α

Purity 9991Clinical Data No Development ReportedSize 10 mM times 1 mL 100 mg

Retinoic acid (Vitamin A acid all-trans-Retinoic acid ATRA) Cat No HY-14649

Retinoic acid is a metabolite of vitamin A thatplays important roles in cell growthdifferentiation and organogenesis Retinoic acidis a natural agonist of nuclear receptorsRARwith s of 14 nM for RARαβγ Retinoic acidIC50

bind to with of 17 nMPPARβδ Kd

Purity 9974Clinical Data LaunchedSize 10 mM times 1 mL 100 mg 500 mg 1 g 5 g

10 Tel 609-228-6898 Fax 609-228-5909 Email salesMedChemExpresscom

RG-12525 (NID 525) Cat No HY-101676

RG-12525 is a a specific competitive and orallyeffective antagonist of the peptidoleukotrienes

and inhibiting LTC4- LTD4-LTC4 LTD4 LTE4and LTE4-inducd guinea pig parenchymal stripscontractions with s of 26 nM 25 nM and 7IC50

nM respectively RG-12525 is also ahellip

Purity gt98Clinical Data No Development ReportedSize 1 mg 5 mg

Rosiglitazone (BRL 49653) Cat No HY-17386

Rosiglitazone (BRL 49653) a Thiazolidinedioneinsulin sensitizer is a selective orally active

agonist with s of 30 nM 100 nM andPPARγ EC50

60 nM for PPARγ1 PPARγ2 and PPARγ respectivelyRosiglitazone binds to PPARγ with a ofKd

approximately 40 nM

Purity 9921Clinical Data LaunchedSize 10 mM times 1 mL 50 mg 200 mg

Rosiglitazone maleate (BRL 49653C) Cat No HY-14600

Rosiglitazone maleate (BRL 49653C) is a potent andselective activator of with s of 30PPARγ EC50

nM 100 nM and 60 nM for andPPARγ1 PPARγ2 respectively and a of appr 40 nM forPPARγ Kd

Rosiglitazone maleate is also an modulatorPPARγof inhibits TRP melastatinhellipTRP channels

Purity 9975Clinical Data LaunchedSize 100 mg 500 mg

SaroglitazarCat No HY-19937

Saroglitazar is a novel peroxisomeproliferator-activated receptor ( ) agonistPPARwith predominant PPARα and moderate PPARγ activitywith values of 065 pM and 3 nM in HepG2EC50

cells respectively

Purity 9803Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 25 mg 50 mg 100 mg

Saroglitazar MagnesiumCat No HY-19937A

Saroglitazar magnesium is a novel peroxisomeproliferator-activated receptor ( ) agonistPPARwith predominant PPARα and moderate PPARγ activitywith values of 065 pM and 3 nM in HepG2EC50

cells respectively

Purity 9885Clinical Data Phase 3Size 10 mM times 1 mL 1 mg 5 mg 10 mg 25 mg 50 mg

Seladelpar (MBX-8025) Cat No HY-19522

Seladelpar (MBX-8025) is an orally active potent(50 effect concentration 2 nM) andEC50

specific agonistPPAR-δ

Purity gt98Clinical Data Phase 3Size 1 mg 5 mg

Seladelpar sodium salt (MBX-8025 sodium salt RWJ-800025 sodium salt) Cat No HY-19522A

Seladelpar sodium salt (MBX-8025) is an orallyactive potent and specific agonist with anPPARδ

of 2 nM showing more than 750-fold andEC50

2500-fold selectivity over the PPARα and PPARγreceptors respectively

Purity 9852Clinical Data Phase 3Size 10 mM times 1 mL 5 mg 10 mg 50 mg

T0070907Cat No HY-13202

T0070907 is a potent antagonist with a PPARγ Ki

of 1 nM

Purity 9934Clinical Data No Development ReportedSize 10 mM times 1 mL 5 mg 10 mg 50 mg 100 mg

TesaglitazarCat No HY-17444

Tesaglitazar is a dual peroxisomeproliferator-activated receptor (PPAR) alphagammaagonist that is more potent on PPARγ than onPPARα with s of 134 μM and 36 μM for ratEC50

PPARα and human PPARα respectively andapproximately 02 μM for both rat and humanhellip

Purity 9624Clinical Data No Development ReportedSize 1 mg

Troglitazone (CS-045) Cat No HY-50935

Troglitazone is a agonist with s ofPPARγ EC50

550 nM and 780 nM for human and murinePPARγreceptor respectively

Purity 9953Clinical Data LaunchedSize 10 mM times 1 mL 10 mg 50 mg 100 mg

wwwMedChemExpresscom 11

VCE-0048Cat No HY-128872

VCE-0048 a semi-synthetic multitargetcannabinoquinoid is a specific and PPARγ CB2

receptor dual agonist with potentanti-inflammatory activity VCE-0048 inhibits

and activates the prolyl-hydroxylases (PHDs) HIFpathway

Purity 9856Clinical Data No Development ReportedSize 5 mg 10 mg

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