Cancer Apoptosis Poster
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Transcript of Cancer Apoptosis Poster
Apoptosis evasionin cancer cells1 DECOY RECEPTOR EXPRESSIONFasL FasL Fas Apo2L/Apo3L Apo2/Apo3 TNF TNFR1 Growth Factor Growth Factor Receptor Withdrawal of Growth Factors
FADD FADD Procaspase8 Procaspase8
TRADD TRAF2 RIP
2 ELEVATED ONCOGENE SIGNALINGRAS
PKC BID p90RSK
APOPTOSIS INHIBITING 3 UPREGULATED PATHWAYS
PI 3-K Ibs FLIP IKKs NF-B CIAP1 Caspase3 Caspase7 Caspase9 Apoptosis ICAD CAD APAF1 SMAC IBID BCLXL MMP HTRA2 Noxa Apoptosis CytoC Apoptosis EndoG AIF Depolarization Oncogenic Signal PUMA ANT BAX BAK VDAC PBR BCL2
CypD BIM Mitochondria p53AIP1
POD PML ZIPK PAR4 Daxx NF-B PARP CAD ATM
EndoG DNA Fragmentation FLIP, CIAP2, BFL1, BCL2 AIF
BAX, BAK, BID, Ras, Noxa, PUMA, APAF1, Survivin
Apoptosis DNA Fragmentation
How cancer cells evade apoptosis1Decoy Receptor Expression
Elevated Oncogene Signaling
Upregulated Apoptosis Inhibiting Pathways
LEGEND ACTIVATION PROTEIN KINASES INDIRECT ACTIVATION DEATH-CAUSING PROTEASES DEATH-INDUCING LIGANDS INHIBITION GROWTH FACTOR TRANSLOCATION APOPTOSIS-INDUCING PROTEINS DEATH RECEPTORS TRANSCRIPTION FACTORLimitless replicative potential
Cancer cells can escape apoptotic programming by upregulating the expression of nonsignaling decoy receptors for the FAS ligand, which may prevent activation of the FAS receptor and downstream apoptosis.
Persistent, and/or elevated signaling from oncogenes can drive cell proliferation that can shift the balance over a cells apoptotic program.
Cancer cells can overcome apoptosis via the upregulation of apoptosis inhibiting pathways, such as the PI 3 kinase (PI 3K)Akt/PKB survival pathway and BCL2 overexpression. Loss of the tumor suppressor gene PTEN also inhibits apoptosis.
The pro-apoptotic regulator, p53, is a key tumor suppressor and is mutated in many cancers.
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Tissue invasion & metastasis
Hallmarks of Cancer
Comprehensive Solutions for Cancer Research From Hallmarks to Biomarkers EMD Millipore is dedicated to developing and refining technologies for the study of cancer. Learn more about our extensive portfolio of high quality solutions for cancer research, including the Upstate, Chemicon, and Calbiochem brands of antibodies, small molecules, signaling pathway panels, invasion and apoptosis assays for immunochemistry, flow cytometry, and multiplex, at www.millipore.com/cancer.
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Insensitivity to proliferation inhibiting signals
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S pr elfol su ife f ra ci tio en n cy sig in na ls
GROWTH FACTOR RECEPTOR