ANTACIDS DO NOT AFFECT β-ACETYLDIGOXIN ABSORPTION
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ANTACIDS DO NOT AFFECT ABSORPTION ... In Contrast to the Reduced Bioavailability Found with Digoxin . ').isnoUmpaireq.by .concurrent use pfthe' antacid. :AI.ucQI (alurn. inLu.m . hy:dcoxicie and magnesium hydroxide), according to a study jn 6 healthy volunteers. They took in random order once every 4 weeks 5 tablets of 'Novodigal' (each containing O.2mg alone or with 3 tablets of 'Alucol' (each containing O. ( 8g aluminium hydroxide and O.06g magnesium hydroxide). Areas under the concentration curves and steady-state plasma levels. showed no significant difference between the bioavailability of alone and combined with' Alucol'. Bonelli. J. el a!.: International Journal of Clinical Pharmacology 15: 337 (Jul 1977) INPHARMA 6th August. 1977 p14
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Transcript of ANTACIDS DO NOT AFFECT β-ACETYLDIGOXIN ABSORPTION
ANTACIDS DO NOT AFFECT ~-ACETYlDIGOXIN ABSORPTION
... In Contrast to the Reduced Bioavailability Found with Digoxin . T-he-~bsorption·of~-acetyldigoxin.('Novodigal ').isnoUmpaireq.by .concurrent use pfthe' antacid. :AI.ucQI ~ (alurn.inLu.m .hy:dcoxicie and magnesium hydroxide), according to a study jn 6 healthy volunteers. They took in random order once every 4 weeks 5 tablets of 'Novodigal' (each containing O.2mg ~-acetyldigoxin) alone or with 3 tablets of 'Alucol' (each containing O. ( 8g aluminium hydroxide and O.06g magnesium hydroxide). Areas under the concentration curves and steady-state plasma levels. showed no significant difference between the bioavailability of ~-acetyldigoxin alone and combined with' Alucol'. Bonelli. J. el a!.: International Journal of Clinical Pharmacology 15: 337 (Jul 1977)
INPHARMA 6th August. 1977 p14
