-HA B A C1 A HA A RPP F - media.nature.com fileα-HA α-Kcr MERGE DAPI α-HA α-Kac MERGE DAPI F-RPP...

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MERGE DAPI α-Kac MERGE DAPI α-Kcr α-HA α-HA D109F-VRPP D109F-VRPP D109F D109F H141A S421A S421D H141A S421A S421D HA-HDAC1 HA-HDAC1 A E426A E424A E426A E424A B Supplementary Figure S7. Various HDAC1 mutations result in loss of both HDAC and HDCR activities. (A) and (B) The various HDAC1 mutants were examined for HDCR activity (A) or HDAC activity (B) by ectopic expression in HeLa cells followed by immunostaining using pan-Kcr or pan-Kac antibody as indicated. Scale bar15 μm.

Transcript of -HA B A C1 A HA A RPP F - media.nature.com fileα-HA α-Kcr MERGE DAPI α-HA α-Kac MERGE DAPI F-RPP...

Page 1: -HA B A C1 A HA A RPP F - media.nature.com fileα-HA α-Kcr MERGE DAPI α-HA α-Kac MERGE DAPI F-RPP F F A A D HA-C1 HA-C1 A A A A A B Supplementary Figure S7. Various HDAC1 mutations

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Supplementary Figure S7. Various HDAC1 mutations result in loss of both HDAC andHDCR activities. (A) and (B) The various HDAC1 mutants were examined for HDCR activity(A) or HDAC activity (B) by ectopic expression in HeLa cells followed by immunostainingusing pan-Kcr or pan-Kac antibody as indicated. Scale bar:15 μm.