β-BLOCKERS — HOW MANY DOSES A DAY?
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- HOW MANY DOSES A DAY ? ... A Single Dose is Enough for BP Reduct ion but Not for Steady j;·Blockade Thed iff ere nces in hypotensive effect between once and thr ice da ily doses of metcoroi ot w ere not statistically significa nt in a r andc mised. double-blind crossover tr ial in 16 hypertensive patients . but plasma drug concentrations fluctuated considerably on the single dose regi men . The pat ients were treated w ith. placebo . rnet oprolo! 3OOmg /day in a si ngle da ily dose . o r metoprol ol 3OOmg/ day in 3 doses. in 3 consecutive a-week periods . • W ith thr ice-daily treatment . plasma values bef ore and after noon did not differ signifi cant ly but with the once daily regimen, samples in the early afte rnoon (about 2 hours afte r the single daily dose) had significantly highe r rnetoprolol concentrations than late morning samples Ip < 0.00 I), • Both drug regimens caused significan t falls in systolic and diastolic BP at all times of the day compa red with placebo (p < 0 .00 1). There were no significan t differences in BP between the 2 regimens. • Both active treatments reduced tate morn ing resting and exercise heart rat es Ip < 0 ,00 1) com pared with placebo. but the reduction in exercise heart rate was significantly smaller with the singledose than with the thrice daily regimen (p < 0.001). Rcybrouck . T . C\ I-\.: British M e4Q1 Journal t : t)86 (27 \tay 1978l INPHARMA 10!;hJune. 1978 p15
Transcript of β-BLOCKERS — HOW MANY DOSES A DAY?
~· BLOCKERS - HOW MANY DOSES A DAY?
... A Single Dose is Enough for BP Reduction but Not for Steady j;· BlockadeThe differe nces in hypotens ive effect between once a nd thrice da ily doses of metcoroiot were not sta tistically significa nt in a
randcmised. dou ble-blind crossover trial in 16 hype rtensive pa tients . bu t plasma drug concentra tions fluctuated considera bly on
the s ingle dose regimen. The patients were trea ted with. placebo . rnetoprolo! 3OOmg/day in a si ngle da ily dose . o r metoprol ol
3OOmg/ day in 3 doses. in 3 consecutive a -week periods .• W ith thrice-daily treatment. plasma values before a nd aft er noon did not differ sig nificantly bu t with the o nce daily
regimen, samples in the ea rly afte rnoon (about 2 hours afte r the s ing le da ily dose) had significa nt ly highe r rnetoprolol
concentrat ions than late morning samples Ip < 0.00 I),• Both d rug regimen s ca used significan t falls in systo lic a nd diastolic BP at all times of the day compared with placebo
(p < 0.00 1). T here were no sig nifican t differences in BP between the 2 regimens .
• Both active treatments reduced tate morn ing resti ng and exercise heart rates Ip < 0,001) com pared with placebo . bu t the
reduct ion in exercise heart ra te was signi ficant ly s maller with the single dose than with the th rice da ily regimen
(p < 0.001).Rcybrouck. T . C\ I-\.: British Me4Q1 Journal t : t)86 (27 \ tay 1978l
INPHARMA 10!;h June. 1978 p15
