Ανοϊκά Σύνδρομα
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Ανοϊκά Σύνδρομα
Transcript of Ανοϊκά Σύνδρομα
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.
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,
(. Alzheimer)
,
,
. .
(. )
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,
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,
.Alzheimer
Lewy
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. Alzheimer
Lewy
.
:
:
:
Prion protein: Creutzfeldt-Jakob disease
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Lewy.
:
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40% >65. 1%/
10% >65. 10-15%/
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Alzheimer
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Dr Alois Alzheimer(1864-1915)
Auguste D
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Alzheimer
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Alzheimer
Alzheimer
10%
90%
APP (25)
-1 (155)
-2 (10)
40-65
35-55
40-70
9,0-16
5,8-6,8
4,4-10,8
APOE4: 6
,
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Alzheimer
.Alzheimer
Alzheimer
>65 6,3%
12%
10,9%
19 %
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Alzheimer
1 4-5
2 < 2
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Alzheimer
50% APOE 4
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Alzheimer
3 Alzheimer
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:
.Alzheimer
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Lewy
,
, , ,
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,
( )
1. Semantic dementia syndrome( )
2. Progressive non-fluent aphasia
( )
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.Alzheimer
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BMJ,1998
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NMDA
AMPA
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NMDA receptors antagonists
NMDA
AMPA
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Placebo
*Donezepil (Aricept )
Rivastigmine (Exelon )
Galantamine (Reminyl )
*
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Reminyl Aricept Exelon
+
--
-
+
- -
+- -
+++
G S
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Guidelines- EFNS Task Force 2006
Reminyl Aricept Exelon
N. Alzheimer
. Lewy
A
bixa
AA A (mod.-severe)
B
A
:
gingo biloba, nootropics, selegiline, estrogens, v.E, Ca antagonists
pentoxyff iline, statins, antiflammatory
B B
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40%
,
6
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1 2
3
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1 2
3
. 1999
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1 2
3
Lilly-LY450139-Ph II
?
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1 2
3
+ m-Ach
AF267B in mice
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1 2
3
45Inhibition of aggregationglycosaminoglycan mim Ph II
clioquinol Cu/Zn chelator
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1 2
3
45
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1999/2000:
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1999/2000:
2003/2005:
(AN1792) (6%)
-cell
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.Alzheime
Cox-2
.Alzheimer;
.Alzheimer;
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24S-Hydroxycholesterol
Alzheimer
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.Alzheimer
7 observational studies1
.Alzheimer
3
.Alzheimer
Alzheimer
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.Alzheimer
0.77 (95%CI 0.45-1.30)
.Alzheimer 0.81 (95%CI 0.56-1.16)
Dementia, 2007
Alzheimer
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.Alzheimer
Statins 0.17 (95%CI 0.03-0.96)
JNNP, 2007
