Wnt/β-catenin pathway

Seminar Spring 2011

Maneeshi Prasad21st Jan 2011

Man

Wnt pathway

• Ligands

• Receptors

• Intracellular components

• Transcription factors

• Interactome

Wnt

• “Wnt” is a combination of Wg (wingless) gene in Drosophila and Int gene in MMTV, two homologous genes

• Wnt are secreted proteins

• 19 Wnt genes in humans and mice

Wnt Receptors

• Receptor tyrosine kinase

• Derailed/RYK

• ROR

• Frizzled-transmembrane receptor

• LRP (lipoprotein-receptor related protein)

• Single-pass Tm proteins

• Cytoplasmic tail phosphorylated by GSK3 and CK1γ

http://www.stanford.edu/group/nusselab/cgi-bin/wnt/main#Diagrams

Wnt Pathway

Wnt signaling

Interactions: Intracellular Components

Intracellular Components

Canonical/Non-canonical Wnt pathway

Wnt Pathway Interactome

Wnt pathway interactions

Role of Wnt signaling

Role of Wnt signaling

• Development

• Neural development: CNS

• Neural crest

• Limb

• Tumor formation

• Cellular growth and proliferation