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An unaltered orthosteric site and a network of long-range allosteric interactions for PNU-120596 in α7 nicotinic acetylcholine receptors Christopher B. Marotta1, Henry A.…
i α-conotoxins targeting neuronal nAChRs: Understanding molecular pharmacology and potential therapeutics This thesis is submitted in fulfilment of the requirements for…
Suppression of neuroinflammation by an allosteric agonist and positive allosteric modulator of the α7 nicotinic acetylcholine receptor GAT107Suppression of neuroinflammation
β2* nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward Taryn E. Griedera,b,1, Morgane Bessonc, Geith Maal-Bareda, Stéphanie Ponsc,…
Exploring the Positive Allosteric Modulation of Human α7 Nicotinic Receptors from a Single-Channel PerspectiveExploring the Positive Allosteric Modulation of Human
814 Towards allosteric receptors – synthesis of β-cyclodextrin-functionalised 22’-bipyridines and their metal complexes Christopher Kremer1 Gregor Schnakenburg2 and…
High-Content Microfluidic Screening Platform Used To Identify σ2R/Tmem97 Binding Ligands that Reduce Age-Dependent Neurodegeneration in C. elegans SC_APP ModelHigh-Content
RESEARCH ARTICLE Identification of a Novel Inhibitory Allosteric Site in p38α Patricia Gomez-Gutierrez1,2, Pedro M. Campos1, Miguel Vega1, Juan J. Perez2* 1 Allinky Biopharma.…
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator Koji Takeoa Shun Tanimurab Takehiro Shinodacd Satoko Osawaa Ivan Krasmirov…
marine drugs Article Orthosteric andor Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models Elena V Kryukova 1† Igor A Ivanov 1†…
Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic CardiomyopathyGlycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer’s disease Jhansi Rani Vangavaragu, Koteswara Rao Valasani, Xueqi Gan, and
A nuclear F-actin scaffold stabilizes RNP droplets against gravity in large cells Marina Feric and Clifford P. Brangwynne Department of Chemical and Biological Engineering,
Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment Spiros A. Vlahopoulos, Osman Cen, Nina Hengen, James Agan, Maria Moschovi,
Allosteric signaling Biochemistry Direct negative feedback Indirect feedback Cyclic processes Allosteric mechanisms Regulation by binding to a site other (άλλος allos)…
Microsoft Word - 69758394-file00.docx1 Amiloride and GMQ allosteric modulation of the GABA-A ρ1 receptor: influences of the intersubunit site. Heather D. Snell and Eric
nature CHeMICaL BIOLOGY vol 9 APRIl 2013 wwwnaturecomnaturechemicalbiology 27 1 article puBLIsHed OnLIne: 24 feBruarY 2013 dOI: 101038nCHeMBIO1185 Human cells respond to…
Biochem J 2013 450 477–486 Printed in Great Britain doi:101042BJ20121305 477 Allosteric inhibition of VIM metallo-β-lactamases by a camelid nanobody Jean S SOHIER* Clémentine…
Anand A. Joshi,†, Thomas F. Murrayψ, and Jane V. Aldrich,§,* Department of Medicinal Chemistry, The University of Kansas, Lawrence, KS 66045 ψDepartment
Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphsStructures of fibrils formed by α-synuclein hereditary disease