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Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase Thibaut Imberdisa Joseph Negria Nagendran…
Defining a Channel voltage and ligand gated leave out pumps ionic accumulation Classical HH−like Kinetic scheme ohmic conductance GHK constant field multiple gates transition…
1 E46K HUMAN -SYNUCLEIN TRANSGENIC MICE DEVELOP LEWY-LIKE AND TAU PATHOLOGY ASSOCIATED WITH AGE-DEPENDENT, DETRIMENTAL MOTOR IMPAIRMENT Kristel L. Emmer1, Elisa A. Waxman1*,…
Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24,
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s diseaseSHORT REPORT Open Access Alleviating
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathiesORIGINAL PAPER A glutaminyl cyclasecatalyzed αsynuclein modification
REVIEW Investigational α-synuclein aggregation inhibitors: hope for Parkinson’s disease Nóra Töröka,b*, Zsófia Majlátha*, Levente Szalárdya and László Vécseia,b…
Proteasomal inhibition by αααα-synuclein filaments and oligomers. Lindersson, E.1¶, Beedholm, R.2¶, Højrup, P.3, Moos, T.4, Gai, W.-P.5, Hendil, K.B.6 and Jensen,…
JCB JCB: ReviewJCB: Spotlight 1 The Rockefeller University Press $30.00 J. Cell Biol. www.jcb.org/cgi/doi/10.1083/jcb.201608060 Early infantile epileptic encephalopathy (EIEE),…
”Visdom är inte en produkt av skolning, utan ett livslångt försök att skaffa sig det.” Albert Einstein Supervisors: Martin Ingelsson, Associate professor Department…
Microsoft Word - 200801105_Kim.docby NMR spectroscopy Tag der mündlichen Prüfung: Parkinson's diseases (PD), are associated with the deposition of proteinaceous
Inoculation of α-synuclein preformed fibrils into the mouse gastrointestinal tract induces Lewy body-like aggregates in the brainstem via the vagus nerveRESEARCH ARTICLE
Preparation and Characterization of Manganese II Complexes with Potential Therapeutic Application against α-Synuclein Aggregation Kate Byrne BSc Medicinal Chemistry Pharmaceutical…
A PNAS Direct Submission (2009) Test if α-synuclein pathology involves direct neuron-to-neuron transmission of α-synuclein aggregates via endocytosis Overall hypothesis:…
1 Characterization and validation of 15 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synuclein monomers fibrils and oligomers…
α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic HallmarksMolecular Neurobiology https://doi.org/10.1007/s12035-021-02558-9
Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapyTau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
REVIEW Open Access and Pamela J McLean1,2* Abstract The accumulation of α-synuclein aggregates is the hallmark of Parkinson’s disease, and more generally of synucleinopathies.
TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson’s disease Seong Su Kanga, Zhentao Zhanga,b, Xia Liua, Fredric…
Gut Feelings About a-Synuclein in Gastrointestinal Biopsies:Biomarker in the Making?Claudio Ruffmann, MD1,2 and Laura Parkkinen, PhD1,2*1Oxford Parkinsons Disease Centre,…