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ARTICLE Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel Binsen Li1 Peng Ge2 Kevin A Murray3 Phorum Sheth1 Meng Zhang3 Gayatri…
Slide 1 Aircraft Instrument Reported 2σ Uncertainty Recommended Bias Correction (g/kg) Recommended 2σ Uncertainty NASA DC-8 DLH 5% K0=0.00732, k1=0.0259, k2=-0.0106, k3=0.000345a…
Cryo-electron microscopy Cryo-EM Garry Taylor www.st-andrews.ac.uk~glt2BL3301 Electron has a wavelength • de Broglie relationship: m v = h λ or λ = h mv • Accelerate…
()Heterogeneity Problem Amit Singer November 11, 2013 Joint work with Gene Katsevich (Princeton) and Alexander Katsevich (UCF) Amit Singer (Princeton University) November
Investigation of the Polymeric Properties of α-Synuclein and Comparison with NMR Experiments: A Replica Exchange Molecular Dynamics Study Chitra Narayanan† Daniel S Weinstock‡…
Slide 1 Status of the SPL cryo-module development (report from WG3) V.Parma, CERN, TE-MSC Outline Reminder of the frame of WG3 Cryomodule Specification meeting (19 th September…
Alpha-synuclein Parkinson’s disease Conference: Lessons from the past 20 years Campus Clínic Universitat de Barcelona May 11-12 2017 PRESENTATION Synucleinopathies are…
Of neurotoxicity and α-synuclein Richard Wilson Clayton DF & George JM (1999) J Neurosci Res 58, 120–129 Presentation outline Motivation for the miniproject Neurons…
Defining the -synuclein interactome In situ Xiuqi Cao Undergraduate Student at Yale University B.S. in Molecular, Cellular & Developmental Biology, 2017 Mentor: Karina…
Cell Biology and Pathophysiology of α-SynucleinJacqueline Burre,1 Manu Sharma,1 and Thomas C. Sudhof2,3 1Appel Institute for Alzheimer’s Disease Research, Brain
α-Synuclein: Experimental PathologyDepartment of Neuropathology and Cell Biology, Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku,
Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice Amanda N Sacinoab Mieu Brooksab Michael A…
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD Deirdre B Hobanab Shelby Shrigleyab Bengt Mattssona…
Characterizing a-Synuclein Membrane Bound Structure Bert Lai (Gray Group) Department of Chemistry and Chemical Engineering California Institute of Technology Thesis Defense…
Neurobiology of Disease A53T Human �-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron Degeneration…
Cell models of lipid-rich α-synuclein aggregation validate known modifiers of α-synuclein biology and identify stearoyl-CoA desaturase Thibaut Imberdisa Joseph Negria Nagendran…
1 E46K HUMAN -SYNUCLEIN TRANSGENIC MICE DEVELOP LEWY-LIKE AND TAU PATHOLOGY ASSOCIATED WITH AGE-DEPENDENT, DETRIMENTAL MOTOR IMPAIRMENT Kristel L. Emmer1, Elisa A. Waxman1*,…
Extracellular gamma-synuclein promotes tumor cell motility by activating β1 integrin-focal adhesion kinase signaling pathway and increasing matrix metalloproteinase-24,
Alleviating toxic α-Synuclein accumulation by membrane depolarization: evidence from an in vitro model of Parkinson’s diseaseSHORT REPORT Open Access Alleviating
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathiesORIGINAL PAPER A glutaminyl cyclasecatalyzed αsynuclein modification