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A3 P2 A3 P2 A2 5’ A2 5’ A1 P3 A1 P3 2-5A · WTP + 2-5A 0.75 ± 0.06 Y310A + 2-5A 0.54 ± 0.05 crystal + 2-5A 0.36 ± 0.03 [RNase L] μM m, arbitrar y unit s K d Supplementary
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