Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

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Supplemental Figure 1

Transcript of Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

Page 1: Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

Supplemental Figure 1

Page 2: Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

Supplemental Figure 2

A B

Page 3: Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

Supplemental Figure 3A

B

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Supplemental Figure 4

F (p

g/m

L)

300

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500SK-OV-3EVSA-TA375HeLa

Secr

eted

TN

F

100

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300 HeLa

1 μM Birinapant No Treatment0

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Supplemental Figure 5

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Supplemental Figure 6

A

B

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Supplemental Figure 7

Page 8: Supplemental Figure 1 · Supplemental Table 1 Kd (nM) Birinapant AVPI (Smac) cIAP1 BIR3

Supplemental Table 1

Kd (nM)Birinapant AVPI (Smac)

cIAP1 BIR3 <1 2cIAP2 BIR3 36 20XIAP BIR3 45 130ML-IAP BIR <1 900

Kd, dissociation constant; cIAP, cellular inhibitor of apoptosis; XIAP, X-linked inhibitor of apoptosis; ML-IAP, melanoma inhibitor of apoptosis.