Biópolis - Scientific Dossier Probiotic ES1

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description

Cereal gluten proteins (gliadin α, β, γ, and ω) are the main environmental factors causative of coeliac disease pathogenesis. The incomplete hydrolysis of gliadin by human enzymes during gastrointestinal digestion leads to the generation of peptides able to trigger cytotoxic and inflammatory signals in intestinal epithelial cells of coeliac disease patients. Clinical manifestations of the disease often include intestinal symptoms and nutrient malabsorption associated with severe mucosal damage. Currently, the only available therapy for coeliac disease patients is the adherence to a strict life-long gluten-free diet. However, compliance with this dietary recommendation is complex, and other alternative or adjuvant strategies are needed. Alterations in the composition of the gut microbiota of coeliac patients are characterized by decreased Bifidobacterium numbers (Nadal et a!., 2007; Sanz et a!., 2007, Collado et a!., 2008; 2009; De Palma et a!., 2010). The association of imbalances in the intestinal microbiota and the positive reported roles that bifidobacteria play on intestinal health have led to the proposed use of probiotics as part of additional and alternative nutritional strategies for improving the quality of life of coeliac patients. The strain Bifidobacterium !ongum ES1 (CECT 7347) is capable to reduce the toxicity and inflammatory potential of gliadin-derived peptides and is an excellent candidate as probiotic for coeliac disease patients.

Transcript of Biópolis - Scientific Dossier Probiotic ES1

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