Η ΕΠΙΡΡΟΗ ΤΩΝ Γ.Π.Σ. ΚΑΙ ΤΩΝ Ζ.Ο.Ε. ΣΤΗΝ ΕΚΤΟΣ ΣΧΕΔΙΟΥ ΔΟΜΗΣΗ
ΟΓΚΟΣ ΚΑΙ ΩΣΜΩΜΟΡΙΑΚΟΤΗΤΑ ΤΩΝ ΣΩΜΑΤΙΚΩΝ ΥΓΡΩΝ
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Transcript of ΟΓΚΟΣ ΚΑΙ ΩΣΜΩΜΟΡΙΑΚΟΤΗΤΑ ΤΩΝ ΣΩΜΑΤΙΚΩΝ ΥΓΡΩΝ
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2 . 2009-2013
, , (electrolyte) (acidbase status)
1
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. . , .
, (diabetes) (hypertension). , (acidbase disorders) . (extracellular volume). . . . 2
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(glomerular filtration rate - GFR). , GFR GFR. GFR
(creatinine) (urea nitrogen). (protons), (sodium) (potassium). , . , . , ( - acidosis) ( alkalosis) . (body fluid) (aqueous solution) (electrolytes) (nonelectrolytes) (intracellular) (extracellular compartment). , . (interstitial fluid) (plasma). , (solute content) . 3
.
(aquaporins), (osmotic equilibrium) (osmolality) (extracellular osmolality). (optimal ionic strength) , , . (homeostatic mechanisms) . , , . . . , (vascular volume). . , , . , 4
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. . , . , (vascular congestion) (pulmonary edema).
(total body water TBW) (deuterium), (tritium), (antipyrine) (aminopyrine). 54% . (fractional water content) (73%) , 45%. , 60%. (40-50%) , , . , 54% 1 kg 2.2 lb, : (L) = (lb) / 4
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10% 10%. 20%. 10% , . . , . (sodium), (chloride) (bromide) , , (mannitol), (inulin) (sucrose) . , , 27 53% . (chloride) 42 53%, . (inulin) (sulfate) , 30-33% . , , 40% . (extracellular volume) : (interstitial volume), 28% , (plasma volume -
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8%) (transcellular water volume - 4%) ( 1-1). 1-1. [*] *
24 L (60%) 16 L (40%) 11.2 L (28%) 3.2 L (8%) 1.6 L (4%)
73 kg (160 lb) 40 L . (luminal fluid of the gastrointestinal tract), (fluids of the central nervous system), (fluid in the eye) (lubricating fluids at serous surface).
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1. .
2. .
8
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3. .
V L M O B D F UD OU E F OY L I S
T T LV OA
9
I TA EL NR CL 2 L ( OGL 8 RUH
ETA EL XR CLU
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4, 5 6. .
COMPOSITIO
10
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COMPOSITIOCATIONS (mmol/l) Na 7 8. .
Pla
1
K
4
Ca Mg
1
0
ANIONS (mmol/l)Cl 9. . Ca+ +
1
HCO3+ +
2
Mg
.
Protein HPO4
1
11
2
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.
10. .
12
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11. .
12. .
13
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13. .
14. .
14
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15. .
V L M MAU E OU E E S RM F U SC M L ID O 16. .
IN E S IT T RT E F P C
15
IN R C L T A E L T B
.
FLUID COM
EXTRACELLUAR FLUID 17. .
PLASMA
INTERS FL
Intra P Per Sy Digestive16