ΗΙV / AIDS….the Greek experience

University Hospital of PatrasKarolina Akinosoglou

the median eGFR 85-86 ml/min 1

~26% of PLHIV with normal eGFR(>90ml/min) at

medium/high risk for chronic kidney disease(CKD) 1 (D:A:D algorithm for CKD prognosis)

~75% with subclinical arterial pathology4

22% at high Framinghamrisk score (FRS) 2

Osteoporosis 11.9%Osteopenia 43.4% 3

22.5% of ≥40ysat increasedfracture risk3

HBV coinfection 5.4%2

HCV coinfection ~12%2

Prevalence & Risks

Methods – Sources used..Background – Just to know our story..

Results - Reality Check..

Conclusions – Actions taken or to be…

• AMACS multicentre prospective study 2003-2013 – cross sectional

analysis, in total 5583 HIV+ patients in Greece

• EMENO study – Greek longitudinal observational study – data

collection 2014-2015, comparison morbidity and risk factors for

adverse cardiovascular events between 5305 HIV(+) and 5951

HIV(-)

• Improvement in virological and

immunologic profile

• Increase in mean age of HIV(+), but also

increase in prevalence of co-morbidities

• Slight decrease in FRS, but increase of %

of patients with FRS >20

• Slight increase in cases of eGFR< 60

• Prevalence of cardiovascular adverse

events is significantly higher in HIV(+),

with DM, dyslipidaemia

Change in HIV(+) patient profile requires for an holistic

approach

• Long term prevention and care of co-morbidities

• Improvement of therapeutic regimens

• Better choice of combination of ART to minimize

cardiovascular and renal adverse events

• EDUCATION, PREVENTION, CARE

100 6778 43 3853

55% GREEK REALITY

1Kalkounou et al, P224 2Pantazis et al, P162 3Siakalis et al, P172 4Psichogiou et al, P179, HIV Glasgow 2016

www.keelpno.gr Oct 2016

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Number of deaths per 1000 pts-years of HIV(+) patients

HIV-RNA (copies/ml) CD4 (cells/ul)

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