Download - Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Transcript
Page 1: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit 

Assunta Senatore, Simona Colleoni, Claudia Verderio, Elena Restelli, Raffaella Morini, Steven B. Condliffe, Ilaria Bertani, Susanna Mantovani, Mara Canovi, Edoardo Micotti, Gianluigi Forloni, Annette C. Dolphin, Michela Matteoli, Marco Gobbi, Roberto Chiesa  

Neuron Volume 74, Issue 2, Pages 300-313 (April 2012)

DOI: 10.1016/j.neuron.2012.02.027

Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 2: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 1

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 3: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 2

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 4: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 3

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 5: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 4

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 6: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 5

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 7: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 6

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 8: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 7

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions

Page 9: Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit Assunta Senatore,

Figure 8

Neuron 2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright © 2012 Elsevier Inc. Terms and Conditions