Microfluidics Design and Chip Application

Microfluidics Design & Chip ApplicationReporter: AGNES PurwidyantriStudent ID no: D0228005

Biomedical Engineering Dept.

MicrofluidicsMicrofluidics refers to the behavior and control of liquids constrained to volumes near the L range.Behavior of liquids in the micro domain differs greatly from macroscopic fluids.Surface tension.Laminar flow.Fast thermal relaxation.Diffusion.Microfluidics was developed in the 1980s, mainly for use in inkjet printers. Microfluidics is an multidisciplinary field with a wide variety of applications.

Micro-channels

Nano-tubesSample Loading And InjectionSubatmosphericPressure ChamberElectro-OsmoticPumpElectro-PneumaticDistributorSmall Volume TransportMicrofluidicDeviceMicro-scale Handling SystemMicrofluidic TechnologiesThe objectives of micro-fluidic systemsMicro-Total-Analysis-Systems (mTAS)One system to provide all of the possible required analyses for a given type problemAll processing steps are performed on the chip No user interaction required except for initializationPortable bedside systems possibleLab-on-a-chipMicroarrayMicro-fluidics in natureAveoli (Lung bubbles)

Micro-fluidics is InterdisciplinaryMicro-FabricationChemistryBiologyMechanicsControl SystemsMicro-Scale Physics and Thermal/Fluidic TransportNumerical ModelingSimulation of micro-flowsMaterial ScienceElectronicsThe fluids in micro-fluidic systemSimple fluidsliquids and gases Complex fluidsimmersed structures, surfactants, polymers, DNA

Injection of a droplet into a micro-channel. Polymer flow in a micro-channel

Cells in a micro-channel. Typical fluidic componentsMicro-channels and channel-circuitFunctional structuresMicro-pump and switchesMixing and separating devices

Channel-circuit

Typical functional structreElectroosmotic PumpingLength scales in micro-fluidic systemsMicro-channel1mm100mm10mm1mm100nm10nmCellular scaleRadius of Gyration of DNAMicrostructure and micro-dropsExtended lenght of DNA Typical size of a chipColloid and polymer molecular size Other flow features for micro-fluidicsLow Reynolds number flowLarge viscous forceLow Capillary number flowLarge surface forceHigh Peclet number flowDisperse and diffusionSlow diffusion effectsSpecial transport mechanismMixing: chaotic mixingSeparation: particle, polymer and DNA9Low Reynolds number flow (Stokes flow)

Reynolds number (Re) is the ratio between inertial force to viscous force

Scaling between intertial force and viscous force in NS equationLength scale LVelocity scale U

Flow classification based on Re

http://www.youtube.com/watch?v=gbDscDSUAg4&feature=channel_pagehttp://www.youtube.com/watch?v=2ghBUcQG1lQ&feature=channel_pageLow Reynolds number flow (Stokes flow)In micro-fluidics, Re