Asni Ramdani
Haemoglobin, Mioglobin and Binding
Mechanism of Oxygen
November, 29, 2011
O2 CARRIER
HAEMOGLOBINMIOGLOBI
N
HEMOGLOBIN
Hemoglobin A (HbA)
Hemoglobin
4 globular protein
4Heme Group
2 sub unit α2 sub unit β
HEMOGLOBINThe totality of amino acid in hemoglobin :
• Sub unit α : 141 residue
• Sub unit β : 146 residue
STRUKTUR HEM
THE FIFTH AND SIXTH COORDINATION POSITION OF HEME
N NFe
N N
1
4 3
2
65
1 2
6
5
34
GLOBIN
BINDING HEME BY GLOBIN
BINDING SCHEME
BINDING OF OXIGEN CAUSE STRUCTURAL CHANGES
MODEL BERURUTAN
MODEL SEREMPAK
PENGIKATAN 2,3-BPG PADA HEMOGLOBIN
MANUSIA
2,3-BISFOSFOGLISERAT / 2,3-BPG /
2,3-DIFOSFOGLISERAT / 2,3-DPG
BPG DECREASE THE BOUNDED OF O2
As stabilisator of deoksihemoglobin status (T status)
Created 1 more “jembatan garam”
OXYGENATION IS REGULATED BY BPG
STRUCTURE OF MYOGLOBIN
Outline of Bohr effect
CO2 + H2O H2CO3, H2CO3 unravel into proton and ions bikarbonat.In the lungs, binding of oxygen by hemoglobin will release protons from hemoglobin.
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