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Page 1: Haemoglobin, mioglobin and binding mechanism of oxygen

Asni Ramdani

 

Haemoglobin, Mioglobin and Binding

Mechanism of Oxygen

November, 29, 2011

Page 2: Haemoglobin, mioglobin and binding mechanism of oxygen

O2 CARRIER

HAEMOGLOBINMIOGLOBI

N

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HEMOGLOBIN

Hemoglobin A (HbA)

Hemoglobin

4 globular protein

4Heme Group

2 sub unit α2 sub unit β

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HEMOGLOBINThe totality of amino acid in hemoglobin :

• Sub unit α : 141 residue

• Sub unit β : 146 residue

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STRUKTUR HEM

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THE FIFTH AND SIXTH COORDINATION POSITION OF HEME

N NFe

N N

1

4 3

2

65

1 2

6

5

34

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GLOBIN

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BINDING HEME BY GLOBIN

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BINDING SCHEME

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BINDING OF OXIGEN CAUSE STRUCTURAL CHANGES

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MODEL BERURUTAN

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MODEL SEREMPAK

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PENGIKATAN 2,3-BPG PADA HEMOGLOBIN

MANUSIA

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2,3-BISFOSFOGLISERAT / 2,3-BPG /

2,3-DIFOSFOGLISERAT / 2,3-DPG

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BPG DECREASE THE BOUNDED OF O2

As stabilisator of deoksihemoglobin status (T status)

Created 1 more “jembatan garam”

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OXYGENATION IS REGULATED BY BPG

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STRUCTURE OF MYOGLOBIN

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Outline of Bohr effect

CO2 + H2O H2CO3, H2CO3 unravel into proton and ions bikarbonat.In the lungs,  binding of oxygen by hemoglobin will release protons from hemoglobin.