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Page 1: BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS

BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS

Amrutha K.S. & Susan Zachariah , MSc. Biopolymer Science

Centre for Biopolymer Science and Technology(CBPST), Kochi

SYNTHESIS

applications

α

Freeze dried

N2

Vaccum

Copolymer

Copolymer

Filtration

Polymer solution

PPL

Copolymer

PPLFiltration

Polymer solution

100°C

72 h

Poly(lactic acid) or polylactide (PLA) is a

biodegradable thermoplastic aliphatic

polyester derived from renewable

resources, such as corn starch , tapioca

roots, sugarcane.

PLA is one of the few types of

biodegradable polymers that have been

widely used in FDA approved medical

devices such as orthopedic fixation

devices, tissue engineering scaffolds and

drug-delivering (micro- or nano- )particles.

Photoluminescence is light emission from

any form of matter after the absorption

of photons (electromagnetic radiation).

PLA is made intrinsically photo-

luminescent without adding traditional

photobleaching organic dyes or cytotoxic

quantum dots.

Biocompatible/ Bioabsorbable.

Biodegradable/ Compostable.

Derived from renewable resources.

Excellent processability and nontoxic.

Very good optical properties in terms of

transparency and gloss.

Biodegradable fluorescent polymers that

exhibit dual-functionality as drug delivery

carriers and imaging probes.

BPLP-PLLAs degradation can be

measured by fluorescent signal decay in

addition to the traditional weight loss

measurements.

Cancer fluorescence imaging and drug

delivery can be done without the need of

conjugation with any organic dyes or

quantum dots.

BPLP-PLLA copolymers emitted strong

fluorescence.

BPLP-Cys-PLLA copolymers provided

exceptionally high quantum yields.

BPLPs has excellent photostability over

traditional organic dyes.

Better photo-bleaching resistance against

continuous illumination over photo-

bleaching organic dyes.

BPLPLs demonstrate excellent

processability.

BPLPLs can be feasibly apply into

theranostic cancer management.

The fluorescence properties of BPLPLs

will empower for both in vitro and in vivo

detections.

By modifying the PLA polymer to be intrinsically fluorescent, it is

useful in bioimaging, diagnosis, sensing and other related applications

including cancer tissue detection and bone regeneration.

Cancer management BPLPLs nanoparticles can target cancer cells and tumors and can

also use it to image the tumors via fluorescence imaging.

During surgery roughly millimeter-sized tumors can be seen down

with the naked eye, other cancerous cells surrounding the tumors

cannot be seen.

If those cells aren’t removed, then the cancer will return.

Since fluorescence imaging is a very sensitive tool, it can be used to

detect those cells that cannot be seen with the naked eye.

It is also used to create 'dual-imaging' nanoparticles for cancer

treatment ( magnetic resonance imaging and fluorescence imaging).

Regenerative engineering• By using BPLPLs the decay of temporary scaffolds for tissue

regeneration can be identified without re-opening the body.

• Can measure tissue regeneration in addition to measuring material

degradation and therefore we can better design our materials to meet

specific medical needs.

Recent developments in the field of polymer science and

technology has led to the development of BPLPLs for the targeted

delivery of proteins to colon, and chemotherapeutic agents to

tumors.

Novel BPLPLs may prepare for oral insulin delivery.

Luminescent polymers for in vivo imaging of amyloid signatures,

diagnostic imaging of Alzheimer's disease (AD) and prion diseases.

DNA /Gene detection.

New synthetic methods have been used to prepare homo and co

polymeric BPLPLs for a wide range of drugs, peptides, and protein

delivery applications.

BPLPLs could also be incorporated in catheters for diagnostic and

therapeutic purposes.

1H NMR spectrum

Microscopic fluorescence image

PLA

http://news.psu.edu/-chemistry--conventional-polymers/biomedical

http://www.bioe.psu.edu

http://www.plastemart.com

http://cordis.europa.eu