BIODEGRADABLE PHOTOLUMINESCENT POLYLACTONES for MEDICAL APPLICATIONS
Amrutha K.S. & Susan Zachariah , MSc. Biopolymer Science
Centre for Biopolymer Science and Technology(CBPST), Kochi
SYNTHESIS
applications
α
Freeze dried
N2
Vaccum
Copolymer
Copolymer
Filtration
Polymer solution
PPL
Copolymer
PPLFiltration
Polymer solution
100°C
72 h
Poly(lactic acid) or polylactide (PLA) is a
biodegradable thermoplastic aliphatic
polyester derived from renewable
resources, such as corn starch , tapioca
roots, sugarcane.
PLA is one of the few types of
biodegradable polymers that have been
widely used in FDA approved medical
devices such as orthopedic fixation
devices, tissue engineering scaffolds and
drug-delivering (micro- or nano- )particles.
Photoluminescence is light emission from
any form of matter after the absorption
of photons (electromagnetic radiation).
PLA is made intrinsically photo-
luminescent without adding traditional
photobleaching organic dyes or cytotoxic
quantum dots.
Biocompatible/ Bioabsorbable.
Biodegradable/ Compostable.
Derived from renewable resources.
Excellent processability and nontoxic.
Very good optical properties in terms of
transparency and gloss.
Biodegradable fluorescent polymers that
exhibit dual-functionality as drug delivery
carriers and imaging probes.
BPLP-PLLAs degradation can be
measured by fluorescent signal decay in
addition to the traditional weight loss
measurements.
Cancer fluorescence imaging and drug
delivery can be done without the need of
conjugation with any organic dyes or
quantum dots.
BPLP-PLLA copolymers emitted strong
fluorescence.
BPLP-Cys-PLLA copolymers provided
exceptionally high quantum yields.
BPLPs has excellent photostability over
traditional organic dyes.
Better photo-bleaching resistance against
continuous illumination over photo-
bleaching organic dyes.
BPLPLs demonstrate excellent
processability.
BPLPLs can be feasibly apply into
theranostic cancer management.
The fluorescence properties of BPLPLs
will empower for both in vitro and in vivo
detections.
By modifying the PLA polymer to be intrinsically fluorescent, it is
useful in bioimaging, diagnosis, sensing and other related applications
including cancer tissue detection and bone regeneration.
Cancer management BPLPLs nanoparticles can target cancer cells and tumors and can
also use it to image the tumors via fluorescence imaging.
During surgery roughly millimeter-sized tumors can be seen down
with the naked eye, other cancerous cells surrounding the tumors
cannot be seen.
If those cells aren’t removed, then the cancer will return.
Since fluorescence imaging is a very sensitive tool, it can be used to
detect those cells that cannot be seen with the naked eye.
It is also used to create 'dual-imaging' nanoparticles for cancer
treatment ( magnetic resonance imaging and fluorescence imaging).
Regenerative engineering• By using BPLPLs the decay of temporary scaffolds for tissue
regeneration can be identified without re-opening the body.
• Can measure tissue regeneration in addition to measuring material
degradation and therefore we can better design our materials to meet
specific medical needs.
Recent developments in the field of polymer science and
technology has led to the development of BPLPLs for the targeted
delivery of proteins to colon, and chemotherapeutic agents to
tumors.
Novel BPLPLs may prepare for oral insulin delivery.
Luminescent polymers for in vivo imaging of amyloid signatures,
diagnostic imaging of Alzheimer's disease (AD) and prion diseases.
DNA /Gene detection.
New synthetic methods have been used to prepare homo and co
polymeric BPLPLs for a wide range of drugs, peptides, and protein
delivery applications.
BPLPLs could also be incorporated in catheters for diagnostic and
therapeutic purposes.
1H NMR spectrum
Microscopic fluorescence image
PLA
http://news.psu.edu/-chemistry--conventional-polymers/biomedical
http://www.bioe.psu.edu
http://www.plastemart.com
http://cordis.europa.eu
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