xx-marijuana and the teen brain - UCSD Cognitive...

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marijuana  and the teen brain MARY  ET  BOYLE,  PH.  D. DEPARTMENT  OF  COGNITIVE  SCIENCE UCSD

Transcript of xx-marijuana and the teen brain - UCSD Cognitive...

Page 1: xx-marijuana and the teen brain - UCSD Cognitive Sciencemboyle/COGS11/COGS11-website/pdf-files/0… · marijuana and the teen brain MARY ET BOYLE, PH. D. DEPARTMENT OF COGNITIVE SCIENCE

marijuana and the teen brainMARY  ET  BOYLE,  PH.  D.

DEPARTMENT  OF  COGNITIVE  SCIENCE

UCSD

Page 2: xx-marijuana and the teen brain - UCSD Cognitive Sciencemboyle/COGS11/COGS11-website/pdf-files/0… · marijuana and the teen brain MARY ET BOYLE, PH. D. DEPARTMENT OF COGNITIVE SCIENCE

in this talk

what is marijuana?

the brain on marijuana

is the teen brain special?

current research

Page 3: xx-marijuana and the teen brain - UCSD Cognitive Sciencemboyle/COGS11/COGS11-website/pdf-files/0… · marijuana and the teen brain MARY ET BOYLE, PH. D. DEPARTMENT OF COGNITIVE SCIENCE

what is marijuana?

cannabis sativa plant leaves, stems flowers

delta‐9‐tetrahydrocannabinol

= Δ9‐THC

main psychoactive ingredient 

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Δ9‐THC is the main psychoactive ingredient

CB1receptor

Δ9‐THC activates cannabinoid1 (CB1) receptor in the brain.

CB1 is expressed at high levels in many brain areas

Two endogenous brain lipids have been identified as CB1 ligands

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endocannabinoids – ligands for CB1

N‐arachidonylethanolamine

anandamide(AEA)

2‐arachidonoylglycerol

2‐AGarachidonate‐derived neuroactive lipids

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what areas of the brain process marijuana?hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellum

brainstem

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

hormones

appetite

circadian rhythms

sexual behavior

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

motor controlled planning

initiation of actions

termination of actions

habit pathway

Page 9: xx-marijuana and the teen brain - UCSD Cognitive Sciencemboyle/COGS11/COGS11-website/pdf-files/0… · marijuana and the teen brain MARY ET BOYLE, PH. D. DEPARTMENT OF COGNITIVE SCIENCE

hypothalamus

basal ganglia

ventral striatumamygdala

cortex

hippocampus

cerebellumbrainstem

prediction

reward

addiction?

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

anxiety

emotion

fear

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

vomiting reflex

pain sensation

sympathetic nervous system 

reactions

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

higher cognitive functions

sensation perception

judgment and pleasure

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

memory formation

learning: facts

sequences

places

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hypothalamus

basal ganglia

ventral striatum

amygdala

cortex

hippocampus

cerebellumbrainstem

motor control

coordination

motor learning

doubles risk of car accident ‐

DUI


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marijuana and the teen brain - pages.ucsd.edupages.ucsd.edu/~mboyle/COGS11/COGS11-website/pdf... · marijuana and the teen brain MARY ET BOYLE, PH. D. DEPARTMENT OF COGNITIVE SCIENCE.

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