ΗΙV / AIDS….the Greek experience · collection 2014-2015, comparison morbidity and risk factors...

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ΗΙV / AIDS….the Greek experience University Hospital of Patras Karolina Akinosoglou the median eGFR 85-86 ml/min 1 ~26% of PLHIV with normal eGFR(>90ml/min) at medium/high risk for chronic kidney disease(CKD) 1 (D:A:D algorithm for CKD prognosis) ~75% with subclinical arterial pathology 4 22% at high Framingham risk score (FRS) 2 Osteoporosis 11.9% Osteopenia 43.4% 3 22.5% of ≥40ys at increased fracture risk 3 HBV coinfection 5.4% 2 HCV coinfection ~12% 2 Prevalence & Risks Methods – Sources used.. Background – Just to know our story.. Results - Reality Check.. Conclusions – Actions taken or to be… AMACS multicentre prospective study 2003-2013 – cross sectional analysis, in total 5583 HIV+ patients in Greece EMENO study – Greek longitudinal observational study – data collection 2014-2015, comparison morbidity and risk factors for adverse cardiovascular events between 5305 HIV(+) and 5951 HIV(-) Improvement in virological and immunologic profile Increase in mean age of HIV(+), but also increase in prevalence of co-morbidities Slight decrease in FRS, but increase of % of patients with FRS >20 Slight increase in cases of eGFR< 60 Prevalence of cardiovascular adverse events is significantly higher in HIV(+), with DM, dyslipidaemia Change in HIV(+) patient profile requires for an holistic approach Long term prevention and care of co-morbidities Improvement of therapeutic regimens Better choice of combination of ART to minimize cardiovascular and renal adverse events EDUCATION, PREVENTION, CARE 100 67 78 43 38 53 55% GREEK REALITY 1 Kalkounou et al, P224 2 Pantazis et al, P162 3 Siakalis et al, P172 4 Psichogiou et al, P179, HIV Glasgow 2016 www.keelpno.gr Oct 2016 Greek population 7.9 13.7 2013 2003 Number of deaths per 1000 pts-years of HIV(+) patients HIV-RNA (copies/ml) CD4 (cells/ul) Percentage
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Transcript of ΗΙV / AIDS….the Greek experience · collection 2014-2015, comparison morbidity and risk factors...

  • ΗΙV / AIDS….the Greek experience

    University Hospital of PatrasKarolina Akinosoglou

    the median eGFR 85-86 ml/min 1

    ~26% of PLHIV with normal eGFR(>90ml/min) at

    medium/high risk for chronic kidney disease(CKD) 1 (D:A:D algorithm for CKD prognosis)

    ~75% with subclinical arterial pathology4

    22% at high Framinghamrisk score (FRS) 2

    Osteoporosis 11.9%Osteopenia 43.4% 3

    22.5% of ≥40ysat increasedfracture risk3

    HBV coinfection 5.4%2

    HCV coinfection ~12%2

    Prevalence & Risks

    Methods – Sources used..Background – Just to know our story..

    Results - Reality Check..

    Conclusions – Actions taken or to be…

    • AMACS multicentre prospective study 2003-2013 – cross sectional

    analysis, in total 5583 HIV+ patients in Greece

    • EMENO study – Greek longitudinal observational study – data

    collection 2014-2015, comparison morbidity and risk factors for

    adverse cardiovascular events between 5305 HIV(+) and 5951

    HIV(-)

    • Improvement in virological and

    immunologic profile

    • Increase in mean age of HIV(+), but also

    increase in prevalence of co-morbidities

    • Slight decrease in FRS, but increase of %

    of patients with FRS >20

    • Slight increase in cases of eGFR< 60

    • Prevalence of cardiovascular adverse

    events is significantly higher in HIV(+),

    with DM, dyslipidaemia

    Change in HIV(+) patient profile requires for an holistic

    approach

    • Long term prevention and care of co-morbidities

    • Improvement of therapeutic regimens

    • Better choice of combination of ART to minimize

    cardiovascular and renal adverse events

    • EDUCATION, PREVENTION, CARE

    100 6778 43 3853

    55% GREEK REALITY

    1Kalkounou et al, P224 2Pantazis et al, P162 3Siakalis et al, P172 4Psichogiou et al, P179, HIV Glasgow 2016

    www.keelpno.gr Oct 2016

    Gre

    ek p

    op

    ula

    tio

    n

    7.9

    13.7

    2013

    2003

    Number of deaths per 1000 pts-years of HIV(+) patients

    HIV-RNA (copies/ml) CD4 (cells/ul)

    Per

    cen

    tage

    http://www.keelpno.gr/