Tyrosine: an amino acid found in proteins such as

meat, nuts, and eggs also Dairy products such

as cheese

the body can synthesize tyrosine from

phenylalanine

MAO

MAO

(COMT)

Guanithidine--

Bretylium --

--SNRIs(duloxetine), Imipramine,

Na+

Na/cl

transporte

Mg++ / ATP

Transporter

reserpine --

Adrenergic Rs:

-two family depending on response to the

adrenergic agonist

(nor epinephrine,epinephrine ,isoproterenol)

1) α - adrenoceptor

Show weak response to synthetic agonist

isoproterenol

epinephrine ≥ nor epineph >> isoproterenol

depending on affinities to agonist

& blocker:

α1:A-D

α1A in urinary tract, α1B in BV

specific agonist: phenylephrine

specific antagonist: prazosin

mech: G-pr Ip3 & DAG

Ca++

located on sm , vascular sm , eye ,

pilomotor sm , prostatic capsule

the effect of α-1 R:

- vasoconstriction (especially skin & viscera but slight in cerebral & coronary arterioles)

peri resis & BP

- veins constriction

-increase closure of bladder sphincter

- mydriasis ( due to contraction of radial muscle of iris)

Alpha receptors

:Adrenergic receptors

Alpha 1 receptors are present in

the radial muscles of the iris

Stimulation of Alpha receptors produces:

Mydriasis

- sweat gland secretion (note)

-pilomotor: piloerection

-male : ejaculation & contraction of

prostatic capsule

-uterus (pregnancy): contraction

- intestinal sm : relaxation

α 2: A-C

specific agonist: clonidine

specific antagonist: yohimbine

mech: G-pr inhibit cAMP

synthesis , K , Ca

located on presynaptic N , β-cell

& sm of veins , git & lipocyte

& in CNS adrenaline release

and hypotension.

α 2-effect

-inhibit norepi release why? hypoten

-inhibit Ach release why?

-inhibit insulin release

- git sm relaxation

-contraction of sphincters of the GIT

-inhibit lipolysis & rennin secretion