DEMI DABOR-ALLOH

TGF-β Receptor II and Gastric Cancer

TGF-β Receptor II is a trans-membrane serine/threonine kinase

TGF β signalling regulates many cell processes

including: Growth Inhibition Cell Migration Invasion Epithelial – Mesenchymal Transition Extracellular Matrix Remodelling Immune - suppression

Knocking out TGF-β receptor II caused embryonic lethality and defects of yolk sac haematopoiesis and

vasculogenesis

Gastric cancer is the second most frequent cause of cancer death in the world after lung cancer.

Some patients with gastric cancer have mutations that truncate the TGF-β RII protein

The TGF-β Paradox: it has Cytostatic effects vs. tumour favouring effects

Surgery is the primary treatment for gastric cancer

http://www.hopkins-gi.org

Total Gastrectomy

Endoscopic Mucosal Resection

Works Cited

Oshima, M., Oshima, H., Taketo, M.M, 1996. TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoesis and Vasculogenesis. Developmental Biology, 179, pp297 – 302.

Yang, H.K., Kang S.H., Kim, Y.S., et al, 1999. Truncation of the TGF-β type II receptor gene results in insensitivity to TGF- β in human gastric cancer cells. Oncogene, 18, pp2213 – 2219.

Akhurst, R.J., Derynck R, 2001. TGF- β signilling in cancer – a double-edged sword. Trends in Cell Biology, 11 (11), pp44 – 49.

Bachman, K.E., Park, B.H, 2005. Duel nature of TGF- β signalling: tumor suppressor vs. tumor promoter. Current Opinion in Oncology, 17, pp49 – 54.

Akhurst, R.J., Hata, A, 2012. Targeting the TGF- β signalling pathway in disease. Nature, 11, pp790 – 807.

Narayan, S., Thangasamy, T., Balusu, R, Transforming Growth Factor – Beta Receptor Signalling in Cancer, 2005. Frontiers in Bioscience, 10, pp1135 – 1145.

Jakowlew, S, 2006. Transforming growth factor- β in cancer and metastasis. Cancer Metastasis Review, 25, pp435 – 457.

Mishra, L., Shetty, K., Tang,Y., et al, 2005. The role of TGF- β and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene, 24, pp5775 – 5789.

de Caestecker, M.P., Piek, E., Roberts, A.B, 2000. Role of Transforming Growth Factor- β Signaling in Cancer. Journal of the National Cancer Institute, 92 (1), pp388 – 402.

Becker, K.F., Keller, G, 2010. Gastric Cancer, Encyclopaedia of Life Sciences.