Synthesis of β-Peroxy-Lactones Using 30% H2O2.

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2005 Dioxole derivatives R 0170 Synthesis of β-Peroxy-Lactones Using 30% H 2 O 2 . — Acid-catalyzed reaction of cy- clopropyl methyl alcohols reveals that hydrogen peroxide and tert-butyl hydroperoxide are efficient traps for cyclopropylmethyl cations. The findings are exploited to develop a novel route to β-peroxy-lactones. The products (IIa) and (IVa) show weak antimalar- ial activity. — (SINGH*, C.; SRIVASTAV, N. C.; SRIVASTAVA, N.; PURI, S. K.; Tetrahedron Lett. 46 (2005) 16, 2757-2759; Div. Med. Chem., Cent. Drug Res. Inst., Lucknow 226 001, India; Eng.) — Mais 32- 126

Transcript of Synthesis of β-Peroxy-Lactones Using 30% H2O2.

2005

Dioxole derivativesR 0170 Synthesis of β-Peroxy-Lactones Using 30% H2O2. — Acid-catalyzed reaction of cy-

clopropyl methyl alcohols reveals that hydrogen peroxide and tert-butyl hydroperoxide are efficient traps for cyclopropylmethyl cations. The findings are exploited to develop a novel route to β-peroxy-lactones. The products (IIa) and (IVa) show weak antimalar-ial activity. — (SINGH*, C.; SRIVASTAV, N. C.; SRIVASTAVA, N.; PURI, S. K.; Tetrahedron Lett. 46 (2005) 16, 2757-2759; Div. Med. Chem., Cent. Drug Res. Inst., Lucknow 226 001, India; Eng.) — Mais

32- 126