Supplementary Figure 1-8 - images.nature.com · VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of...

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VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of BrdU- positive cells WT Disc1 LI * BrdU BrdU/DAPI Supplementary Figure 1 SVZ VZ a 100μm WT Disc1 LI 0 10 20 30 40 Number of PH3- positive cells in the VZ WT Disc1 LI * PH3 PH3/DAPI b SVZ VZ VZ

Transcript of Supplementary Figure 1-8 - images.nature.com · VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of...

Page 1: Supplementary Figure 1-8 - images.nature.com · VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of BrdU- positive cells WT Disc1 LI BrdU BrdU / DAPI Supplementary Figure 1 SVZ VZ a

VZ

100μm

WTDisc1 LI

0

100

200

300

400

Num

ber o

f Brd

U-

posi

tive

cells

WT Disc1 LI

*

Brd

UB

rdU

/DA

PI

Supplementary Figure 1

SVZ

VZ

a

100μm

WTDisc1 LI

0

10

20

30

40

Num

ber o

f PH

3-po

sitiv

e ce

lls in

the

VZ

WT Disc1 LI

*

PH

3P

H3/

DA

PI

b

SVZ

VZ

VZ

Page 2: Supplementary Figure 1-8 - images.nature.com · VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of BrdU- positive cells WT Disc1 LI BrdU BrdU / DAPI Supplementary Figure 1 SVZ VZ a

100μm 0 10 20 30 40 50 60 (%)

1

2

3

4

5

6

7

8

9

10

Cel

l dis

tribu

tion

of b

in a

naly

sis

WTDisc1 LI

0

0.2

0.4

0.6

0.8

Mig

ratio

ndi

stan

ce

(A.U

.)

WT Disc1 LI**

*

**

Brd

UB

rdU

/DA

PI

Supplementary Figure 2

CP

IZ

VZ/SVZ

a

100μm 0

1

2

3

4

5

6

7

8

9

10

Cel

l dis

tribu

tion

of b

in a

naly

sis

WTDisc1 LI

0

0.2

0.4

0.6

0.8

Mig

ratio

ndi

stan

ce

(A.U

.)

WT Disc1 LI**

**

***

**

GFP

GFP

/DA

PI CP

IZ

VZ/SVZ

b

10 20 30 40 50 60 (%)

CP

IZ

VZ/SVZ

CP

IZ

VZ/SVZ

Page 3: Supplementary Figure 1-8 - images.nature.com · VZ 100μm WT Disc1 LI 0 100 200 300 400 Number of BrdU- positive cells WT Disc1 LI BrdU BrdU / DAPI Supplementary Figure 1 SVZ VZ a

100μm 0

1

2

3

4

5

6

7

8

9

10

Cel

l dis

tribu

tion

of b

in a

naly

sis

Cont RNAiDISC1 RNAi

0

0.2

0.4

0.6

0.8

Mig

ratio

ndi

stan

ce

(A.U

.)

Cont RNAi DISC1 RNAi

WT **

***

**

*

GFP

GFP

/DA

PI

Supplementary Figure 3

CP

IZ

VZ/SVZ

a

100μm 0

1

2

3

4

5

6

7

8

9

10

Cel

l dis

tribu

tion

of b

in a

naly

sis

Cont RNAiDISC1 RNAi

0

0.2

0.4

0.6

0.8

Mig

ratio

ndi

stan

ce

(A.U

.)

Cont RNAi DISC1 RNAi

Disc1 LI

n.s.

GFP

GFP

/DA

PI CP

IZ

VZ/SVZ

b

10 20 30 40 50 60 (%)

10 20 30 40 50 60 (%)

CP

IZ

VZ/SVZ

CP

IZ

VZ/SVZ