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SMC – a one-shop-stop for the pharmaceutical industry

SMC - working in the pharmaceutical industry:

As the world´s leading experts in pneumatics, with more than 360 sales offi ces in 78 countries, we have developed a truly impressive and extensive portfolio of highly sophisticated automation related products.

Today, our standard product range exceeds 11.000 items, with over 630.000 variant forms, with many specifi ed and used in a growing number of pharmaceutical applications throughout the world.

With a focus on component quality and long life-cycle performance SMC products can help increase your productivity, guarantee the highest levels of manufacturing quality and also reduce both waste and energy consumption.

By selecting an SMC product for your next pharmaceutical application outstanding operational performance is a given and peace of mind is ensured.

Understanding the needs of the pharmaceutical industry:

The pharmaceutical industry is one of the most highly regulated industries in the world.

As leaders in our fi eld, our highly trained pharmaceutical industry experts recognise and fully understand the strict standards set by organisations like the FDA (USA´s Food and Drug Administration) and the GMP (Good Manufacturing Practise) guidelines from the International Society for Pharmaceutical Engineering.

With more than1.360 dedicated R&D engineers located at our Technical Centres around the world, we are an organisation committed to continuous product development and product improvement.

And for this reason, the introduction of the PAT initiative (process analytical technology) from the FDA, which promotes the tangible benefi ts of using new technology in pharmaceutical manufacturing processes to increased yields, reduce waste and save money, is path that we also follow and fully applaud.

Through our industry knowledge, we recognise the pharmaceutical industry´s unique mix of both process and discreet manufacturing processes, including the growing use of automation in R&D laboratories seen during the last decade.

From process automation applications used in primary manufacturing, through to secondary manufacturing applications, including formulation and fi nal packaging, and fi nally the use of automation in laboratories, SMC can provide you with accurate, high quality, cutting edge product solutions to meet all your pharmaceutical needs.

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Series PF3WDigital Flow Switch for Water• Integrated temperature sensor• Space saving, reduced piping space• 3 colour/2 screen integrated or remote display• Rotatable display: easy operation, improved visibility• Analogue output: 1-5 V or 4-20 mA• Switch output: PNP/NPN• Integrated flow adjustment valve• Accumulated pulse output (NPN/PNP)• Accumulated flow output (NPN/PNP)• External input (NPN/PNP)• Four type of flow range: 0.5 ~ 4 l/min, 2 ~ 16 l/min,

5 ~ 40 l/min, 10 ~ 100 l/min

A selection of SMC products developed and used in the pharmaceutical industry:

� Flow and pressure switches

Series PFM2-Colour Display Flow Switch• For air, N2, Ar and CO2• A compact digital flow switch that uses MEMS sensor

for detecting the flow• Improved visibility with two colour display indication• Two piping directions are possible• Integrated flow adjustment valve• Multiple mounting combinations• Flow rate range: 10, 25, 50, 100 l/min

Series PFMVFlow Sensor and Voltage Monitor• Suction check of very small workpieces• PFMV5: Flow sensor

PFMV3: Voltage monitor for PFMV5• Reduced piping space• Response speed: 5 ms or less• Applicable fluid: Dry air, N2 and Ar• Flow rate range: 0.5, 1, 3 l/min

Series PF2DDigital Flow Switch for Deionised Water & Chemicals• Dust generation of 3 particles/cc or less (average

number)• Karman vortex eliminates moving parts and allows low

dust generation• Swept flow characteristics• Tapered side seal minimises dead volume to reduce

accumulation of liquid pool• Body and Sensor: New PFA• Tube: Super PFA• Three type of flow range: 0.4 ~ 4 l/min, 1.8 ~ 20 l/min,

4.0 ~ 40 l/min

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� Sensors Series PSE550Low Differential Pressure Sensor• For air or dry gases• Measures ± 2 kPa (0.3 Psi)• 1-5 V or 4-20 mA analogue output options• Direct connection of 4 mm ID tubing• Typical applications, filter back pressure monitoring or

fan output checking• Mounting bracket available• Integrated indicator light

Series PSE560Pressure Sensor for General Fluids• Pressure sensor for general purpose fluids (controller:

PSE300)• Wetted material: SUS316L• Pressure range: positive pressure [0 to 500] kPa and

[0 to 1] MPa, vacuum [0 to101] kPa, compound pressure [–100 to 100] kPa

Series PSE200Multi-channel Controller• Sensor controller unit for 4 sensor inputs• Automatic sensor recognition• Auto shift function

Series ISE80/ZSE802-Colour Display Digital Pressure Switch• 4 Rated pressure range: 0.0 to –101.0 kPa; -100.0 to

100.0 kPa; –0.100 to 1.000 MPa; –0.100 to 2.00 MPa• Stainless diaphragm (Oil-free Single-layer diaphragm) Sensor parts: Stainless steel 630 Fitting parts: Stainless steel 304• For use with water, hydraulic fluid, silicon oil, lubricant,

fluorocarbon, Ar, ammonia, CO2, air-containing drainage and N2

• Outputs: analogue (1-5 V, 4~20 mA), 1/2 x PNP/NPN

Series ISE30AAdjustable Positive Pressure Switch with Display• For use with air and nitrogen• Enclosure IP40• 2 colour (green/red), large, easy-to-read display• Easy operation: 3-step setting and copy function• Analogue output: 4-20 mA or 1-5 V• Switch output: 2 PNP/NPN or 1 PNP/NPN

Series ISE40AAdjustable Positive Pressure Switch with Display• For use with air and nitrogen• Enclosure IP65• 2 colour (green/red) display• Easy operation: 3 step setting and copy function• Outputs: analogue (1-5 V, 4~20 mA), 1/2 x PNP/NPN

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Series ASGStainless Steel 316 Controller (Elbow type)• Stainless steel 316 and special FKM construction to

improve the resistance to corrosion• Elbow design to allow the rotation of the tubing

connection ports and suit installation to air cylinders• Meter-in and meter-out type control• One-touch fittings and 5 body sizes

Series KQG2Stainless Steel 316 One-touch Fittings• Material: Metal parts: Stainless steel 316 Seal parts: Special FKM• Can be used with air, water and steam• Operating fluid temperature: –5 to 150°C• Grease-free• Applicable tubing material: FEP, PFA, nylon, softnylon,

polyurethane, polyolefin

Series KFG2Stainless Steel 316 Insert Fittings• Material: Stainless Steel 316• Operating fluid temperature –65 to 260°C• Can be used with steam• Grease-free• Applicable tubing material: FEP, PFA, modified PTFE

nylon, softnylon, polyolefin polyurethane, soft polyurethane, hard polyurethane, soft polyolefin, antistatic softnylon, antistatic polyurethane

� Stainless steel products

Series SRHContamination Controlled Stainless Steel 316/316L Regulator• Outstanding corrosion resistance• Oil-free• Low particulate contamination • Two types of diaphragm materials: PTFE, Fluororubber• Designed to minimize residual fluid• Pulsation suppressing design• Consistent clean room production• Wetted parts (metal): Stainless steel 316 (Body is

SUS316L)• On demand: all wetted parts in 316L / Tri-Clamp

connections

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Series CJ5-S/CG5-SStainless Steel Cylinder• SUS304 - stainless steel• Special scrapers provide optimum piston rod sealing• Seals either NBR or FKM• FDA approved grease suitable for food processing

applications• CG5 can be disassembled, therefore

maintenance-friendly

� Air filtration Series AFFilter• In stacking manifold or as single device• Filtration degree 5 μm• Optional manual or automatic drain• 3 bowl materials for different types of use

(polycarbonate, nylon, metal)• Filter cartridge element can be changed quickly.• Temperature range -5 to 60°C• Vertical mounting position

Series AFMMist Separator• In stacking manifold or as single device• Filtration degree 0.3 μm• Residual oil concentration at the outlet max. 1 mg/m³• Filter cartridge element can be changed quickly• Temperature range -5 to 60°C• Vertical mounting position

Series AFDMicro-Mist Separator• Filtration 0.01 μm• Residual oil concentration at the outlet max. 0.1 mg/m³• Filter cartridge element can be changed quickly• Temperature range -5 to 60°C• Vertical mounting position

Series HYHygienic Design Cylinder• Four body types, compact, ISO/VDMA, guide rounded

profile• Water resistant to resist washdowns• No external grooves or crevices to trap dirt• External switch rail and IP67 autoswitches available• Mounting dimensions meet ISO/VDMA standards• NBR or FKM external seals with food grade grease

option• Hygienic smooth design for easy cleaning• Clearance under switch rail to avoid trapping debris• Mounting brackets are available, plus cover plates for

HYQ• Bore sizes from 20 mm to 100 mm

HYBRound type

HYQCompact type

HYCISO standard type

HYGGuide rod type

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Series AMFOdour Removal• Active carbon filter for filtering odours• Filtration degree 0.01 μm• Residual oil concentration at the outlet max. 0.004 mg/m³• 13 layers of active carbon ensure optimum

effectiveness• Operating pressure range 0.05 to 1.0 MPa• Temperature range 5 to 60°C• Modular connection (AMF150C to 550C)

Series SFAClean Gas Filter• Cartridge Type / Disc Style• Precision filtration for general gases: compressed air,

nitrogen, etc• PTFE membrane element is made into a cartridge

(polyester holder and fluorine rubber/FKM gasket)• Filtration 0.01 μm• Elements are replaceable

Series SFBClean Gas Filter• Cartridge Type / Straight Style SFB100/200• Disposable Type / Straight Style SFB300• Precision filtration for general gases: compressed air,

nitrogen, etc• Element: PTFE membrane (SFB100/300), stainless

steel 316 sintered metal (SFB200) • Nominal filtration: 0.01 μm (SFB100/300), 120 μm

(SFB200)• Bracket is included as standard

Series SFCClean Gas Filter• Disposable Type / Multiple Disc Style • Precision filtration for general gases: compressed air,

nitrogen• PTFE membrane with high reliability • Filtration 0.01 μm

Series SFDClean Gas Filter• Disposable Type / Straight Style SFD100• Cartridge Type / Straight Style

SFD200/SFD101/SFD102• Filtration in a clean environment for air or nitrogen• Hollow fibre element• Case material: resin (SFD100/200), aluminium

(SFD101), stainless steel (SFD102)• Filtration 0.01 μm

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� Temperature control

Series HRSCirculating Fluid Temperature ControllerThermo-Chiller Compact Type• Compact and lightweight• Power supply options for global applications• Energy saving (with heating function)• Easy maintenance: tool-less maintenance of filter• Self diagnosis function and check display• Convenient functions: - Timer operation function - Low tank level detection function - Power failure auto-restart function - Anti-freezing operation function• Communication function: RS232C, RS485 and contact

I/Os as standard

Series LLBClean Air Module• Modular clean equipment (reduction of piping

labour/space-saving). Easily available clean air• Nominal filtration rating: 0.01 μm• Wetted parts: Grease-free, Silicon-free• Assembled in a clean room, shipped and packed in

duplicate packaging• 24 combinations available

Series HEBThermostatic Bath• High-precision temperature-regulation thermostatic

chamber that employs Peltier elements• Compact and low vibration• Unique agitation method keeps up-down temperature

distribution to a minimum

Series HECThermo-con• For applications requiring high-precision temperature

control• High-precision, refrigerant-free temperature control

equipment employing Peltier elements• Simple structure and high reliability• Can easily be built into equipments with compact and

low-vibration design• Compatible with wide range of power supply voltages• Conforms to UL standard, CE marking

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� Tubing

Series TDSoft Fluoropolymer Tubing• Improved flexibility by approximately 20%• Material: Denatured PTFE. Operating temperature max.

260°C• Conforms to FDA §177•1550• Ten different diameter sizes - in both imperial and

metric

� Grippers

Series MHZJ2Parallel Air Gripper with Dust Cover• ø6, 10, 16, 20, 25• Applicables in alimentary industry, assembly lines,

machine tool, etc• Dust tight, drip proof construction• Dust cover material selectable

Series TLHigh Purity Fluoropolymer Tubing• Outstanding corrosion resistance• Compatable with max fluid temperature up to 260°C• High purity and low particulate generation• Erfüllt die Vorgaben der FDA § 177•1550• Material PFA 451HP-J• Fourteen different diameter sizes - in both imperial and

metric

Series THFEP (Fluoropolymer) Tubing• Heat resistance to 200°C• 4 Colour variations• General pneumatic piping applications (Food,

Semiconductor, Medical care and Automotive)• Erfüllt die Vorgaben der FDA §177•1550• Material FEP 130-J• Nineteen different diameter sizes - in both imperial and

metric

Series MHK2Wedge Cam Operation Slide Guide Air Gripper• ø12, 16, 20, 25• Gripper fingers have robust slide bearing• Elastic guide cover in 3 different materials as

protection against soiling by dust, chips, liquids, etc• 2 Series: MHK2 standard, MHKL2 larger finger

opening stroke

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� High Purity Teflon Series

� Process Pump Series

Series LVHIgh Purity Chemical Valve• Piston damper to minimise particle generation• PTFE diaphragm to prevent micro-bubble generation• New PFA body provides outstanding corrosion

resistance

Threaded Ports Series LVA• Wetted parts material: PFA, Stainless steel or PPS

(body), NBR, EPR or PTFE (diaphragm)

Integral Fittings Series LVC• High temperature chemical fluid handling possible

(100ºC)• Wetted parts material: PFA (body), PTFE (diaphragm)

Manual Operation Series LVH• Locking and non-locking types available• Integral fitting type / Threaded type

Series LVD2 Port Air Operated• Compact valve: dimension across inlet/outlet ports

reduced by up to 25%.• Minimal internal dead volume.• Integral fitting construction: Hyper Fitting® Series.• Piston damper to minimise particle generation.• Piping from 4 directions possible.• Wide range of valve variations available.• Wetted parts materials: PFA / PTFE.

LVA

LVC

LVH

LVD

Series PAF3000/5000Automatically Operated Type• Excellent corrosion resistance - Body material: new

PFA; Diaphragm, seal material: PTFE.• Automatically operated (discharge flow rate max. 45 l/min)

/ air operated (discharge flow rate max. 38 l/min)

Series PB1313AProcess Pump, Air Operated• Single acting pump• Compact, high capacity diaphragm pump to transfer

and deliver a wide variety of fluids• Discharge flow rate: max. 1 l/min• Wetted part material: Polypropylene SUS316

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Series SY3000/5000Solenoid Valves 5 Port, Manifold Type• Highly flexible• Long life circle• Inside cabinet mounting is possible with bottom type• Energy saving:

0.1 W with power saving circuit0.35 W standard

• Space saving: 10 mm widthTop, bottom, side porter available

• Wiring, piping and operation are integrated in one side• Direction, size and type of the piping can be changed

Series IZS31Ionizer• Three ion emission modes: sensing DC, pulsed DC or

DC modes• Maximum 60 Hz ion generation frequency• Two types of compact sensors are available:

Autobalance sensor and Feedback sensor• Aerodynamic cross section• Air purge function for even faster static electricity

elimination• Three types of needle material: Tungsten (standard),

silicon and stainless steel• Replaceable electrode needles• Dirt detection

Series LVMGas and Chemical Liquid Valve• Direct operated diaphragm type valve• Valve chamber volume up to 20 μl or less• Minimal internal dead volume• Compactness (width: 13 mm) and lightweight (30 g or

less)• Energy saving: low power consumption (1-2.5 W)• Service life of 10 million cycles. (Based on SMC test

conditions)• Body ported and base mounted valve options• Wetted parts material: PEEK or PFA. Base mounted

valve only (plate) and EPDM, FKM, or Kalrez® (diaphragm)

• Other voltages available (DC)

� Valves Series

� Ionizer Series

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� Electric drivers Series

� Gas handling components

Series LE� “Easy Setting” Electric ActuatorsOur expanding range of high performance electric actuators, combine the best features of pneumatic cylinders with the accuracy and strengths of electric drives. Easy to programme – thanks to their in-built “easy setting” software - these actuators can be installed and fully operational within minutes when used in conjunction with our new LECP1 Controller. Available in comprehensive range of model options these electric actuators, which can accommodate up to 64 speed and positioning settings, really do offer outstanding operational performance. Series LE� options include:• linear actuator model types • electric grippers types - including our LEHZJ models,

which incorporate special protective covers for dust protection

• rotary actuator model types • LECP1 – easy to use controller

AP Tech – a specialist business within the SMC Corporation: AP Tech, also known as Advanced Pressure Technology, manufactures a wide array of gas handling components used predominately in the Semiconductor, Life Science and Pharmaceutical markets. Pressure regulators, valves, check valves and a variety of flow devices are available for applications ranging from the source cylinder cabinet, bulk delivery systems through point of use including VMB distribution boxes and process tool gas trays. Products can be tailored for specific needs with custom fittings, dimensions, porting or testing with an option of multi-port, mono-block and surface mount configurations. For more information on the AP Tech range contact your nearest SMC office today.

Series LAT3 NEW PRODUCTCard Motor

Similar in size to a credit card, this extremely compact linear actuator offers outstanding speed and accuracy.

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� Plastic Manifold & Valve

� Cleanroom Products

� SMC Pneumatic Clean SeriesBy recognising the needs of specialist industry sectors, we have developed one of the largest portfolios of clean room manufactured products around. With our state-of-the-art manufacturing facilities and highly trained clean room technicians, we guaranteed that any product selected from our SMC Clean Series will meet the right standards and levels for all your applications needs.

Our Clean Series Catalogue (CAT.E02-23A) includes:

• Air Cylinders • Rotary Actuators • Air Grippers • Directional Control Valves • Flow Control Equipment

• Filters and Pressure Control Equipment

• Fittings and Tubing • Air Preparation Equipment • Pressure Switches • Clean Gas Filters

For information on our extensive range of clean room manufactured products please contact your nearest SMC office.

Custom Engineered Plastic Manifold & Valve TechnologyTo help:• Reduce space• Reduce weight• Reduce installation time and error• Reduce cost of ownership

SMC offers you the benefit of single source supply of plastic manifolds and valves.• With a wide selection of valves to meet our customers’

needs• Using our highly experienced in-house design

resource

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� Applications

Series HRSSeries HRS is a new range of thermo chiller units that are ideal for use in blister packaging machines.When used in these applications, the HRS thermo chiller can heat the blister tooling at beginning of the process and then cool the tooling during production.Advantages of using an HRS in your blister packing machine:

- Only one device needed for both heating and cooling- Overall weight reduction- Less installation space required- Cost savings

Reagent cooling equipmentConcentrating equipmentAtomizing device

Temperature control of reagentTemperature control of concentrationfluid

Temperature control of sampleand device

Series SRHAs a part of our gas regulator range Series SRH, we have developed a clean gas option Series SRH4011, with all wetted parts made of stainless steel 316L. This regulator is the perfect solution for applications that require clean air flow such as drying vials. Available with optional Tri Clamp connections, subject to order, this regulator has been designed to meet the needs of a growing number of pharmaceutical applications.

Clean rooms

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SMC – a one-shop-stop for the pharmaceutical industry

Three of the most important demands from the pharmaceutical industry are: reliability, flexibility and speed.

SMC has the resources and capability to meet these demands.

With a comprehensive range of products and innovative solutions we can support our pharmaceutical customers throughout the complete process – production, packaging and analysis.

SMC offers products with FDA certified materials and has:

- the widest range of pneumatic products on the market- an expanding range of new “easy to programme” electric drives- an extensive portfolio of process valves- a large selection of instrumentation components including pressure and flow sensors- Clean room and high purity products- a growing range of high performance thermo chiller and thermo controllers- an extensive range of products developed for analytical devices and laboratories – see our Life Science catalogue for more details

Series AXT115 – Quick-acting valve for high speed sorting applications Given the increasing demand from the industry we have developed a range of quick-acting valves with a switching time of ON/OFF 2.5 ms respectively. They are ideal for tablet presses and sorting applications, both before and after pressing. These valves are available as a flange version and can be used for numerous applications.

CAD Model AXT115

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SMC CORPORATION (Europe)

Specifications are subject to change without prior noticeand any obligation on the part of the manufacturer.

SMC CORPORATION Akihabara UDX 15F, 4-14-1, Sotokanda, Chiyoda-ku, Tokyo 101-0021, JAPAN Phone: 03-5207-8249 FAX: 03-5298-53621st printing QU printing QU 05 Printed in Spain

Lithuania +370 5 2308118 www.smclt.lt info@smclt.ltNetherlands +31 (0)205318888 www.smcpneumatics.nl info@smcpneumatics.nlNorway +47 67129020 www.smc-norge.no post@smc-norge.noPoland +48 (0)222119616 www.smc.pl office@smc.plPortugal +351 226166570 www.smc.eu postpt@smc.smces.esRomania +40 213205111 www.smcromania.ro smcromania@smcromania.roRussia +7 8127185445 www.smc-pneumatik.ru info@smc-pneumatik.ruSlovakia +421 (0)413213212 www.smc.sk office@smc.skSlovenia +386 (0)73885412 www.smc.si office@smc.siSpain +34 902184100 www.smc.eu post@smc.smces.esSweden +46 (0)86031200 www.smc.nu post@smc.nuSwitzerland +41 (0)523963131 www.smc.ch info@smc.chTurkey +90 212 489 0 440 www.smcpnomatik.com.tr info@smcpnomatik.com.tr UK +44 (0)845 121 5122 www.smcpneumatics.co.uk sales@smcpneumatics.co.uk

Austria +43 (0)2262622800 www.smc.at office@smc.atBelgium +32 (0)33551464 www.smcpneumatics.be info@smcpneumatics.beBulgaria +359 (0)2807670 www.smc.bg office@smc.bg Croatia +385 (0)13707288 www.smc.hr office@smc.hrCzech Republic +420 541424611 www.smc.cz office@smc.cz Denmark +45 70252900 www.smcdk.com smc@smcdk.com Estonia +372 6510370 www.smcpneumatics.ee smc@smcpneumatics.eeFinland +358 207513513 www.smc.fi smcfi@smc.fiFrance +33 (0)164761000 www.smc-france.fr promotion@smc-france.frGermany +49 (0)61034020 www.smc.de info@smc.deGreece +30 210 2717265 www.smchellas.gr sales@smchellas.grHungary +36 23511390 www.smc.hu office@smc.huIreland +353 (0)14039000 www.smcpneumatics.ie sales@smcpneumatics.ieItaly +39 0292711 www.smcitalia.it mailbox@smcitalia.itLatvia +371 67817700 www.smclv.lv info@smclv.lv

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