Slurry Prep Systems

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PRODUCT DESCRIPTION | UME97L01-2.0 Slurry Prep Systems Simplify media preparation and packing for DAC LC Columns Dynamic axial compression (DAC) is the most popular type of large-scale liquid chromatography (LC) column technology for packing 10 to 40 μm particle size chromatography media. At Asahi Kasei Bioprocess, we understand that the column is only one element of a successful and efficient purification suite in your plant. That’s why we continue to expand our portfolio of accessories to make your column operation as easy as possible. Built For You With our lineup of 100 to 600 L Slurry Prep Systems (SPS), you can now slurry, de-fine and charge your chromatography media in a closed mixing unit that easily integrates with your large diameter DAC LC Column. Whether you’re packing a 10 μm spherical silica gel or a 35 μm polystyrene bead, our SPS will ensure that you have a reproducible column packing experience every time.

Transcript of Slurry Prep Systems

Page 1: Slurry Prep Systems

PRODUCT DESCRIPTION | UME97L01-2.0

Slurry Prep SystemsSimplify media preparation and packing for DAC LC Columns

Dynamic axial compression (DAC) is the most popular type of large-scale liquid chromatography (LC) column technology for packing 10 to 40 μm particle size chromatography media. At Asahi Kasei Bioprocess, we understand that the column is only one element of a successful and efficient purification suite in your plant.

That’s why we continue to expand our portfolio of accessories to make your column operation as easy as possible.

Built For You With our lineup of 100 to 600 L Slurry Prep Systems (SPS), you can now slurry, de-fine and charge your chromatography media in a closed mixing unit that easily integrates with your large diameter DAC LC Column.

Whether you’re packing a 10 μm spherical silica gel or a 35 μm polystyrene bead, our SPS will ensure that you have a reproducible column packing experience every time.

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Thoughtful DesignThe multi-function design of the SPS permits slurry to be mixed, de-fined, recirculated and charged into DAC LC Columns. The unit is also fully non-electrical, allowing seamless installation into hazardous areas without additional costs for electrical protection or controls validation.

Slurry Prep Systems are compatible with Flash, MPLC and HPLC DAC Columns. The standard SPS includes the following:

» Electropolished 316L SS mixing vessel

» Pneumatic control panel and liquid control panel for manual operation

» Agitator with speed control

» Sidewall sight glass for monitoring slurry level

» Integral decanting dip tube for de-fining

» Slurry transfer pump with speed control

» De-fine, Reslurry, Recirculate and Charge modes

» ASME code stamp (for US installations)

» CE Pressure Equipment Directive compliant (for EU installations)

Simplify Your Slurry Preparation Therapeutics in the 5 to 15 kDa range, such as insulins and oligonucleotides, utilize rigid and spherical chromatography media to achieve the appropriate chromatographic separation. As these processes are scaled up to ever larger column diameters, the need to successfully pack media for commercial manufacturing of drug substance becomes more critical.

These media are based on a wide range of matrices including silica gel, polystyrene-divinylbenzene, polymethacrylate, agarose and hydroxyapatite, each with its own packing properties. The SPS is engineered to manage a range of chromatography media, with gentle mixing and multiple modes of operation. With standard sizes starting at 100 L volume and customized versions available up to 1000 L, Asahi Kasei Bioprocess can accommodate nearly any media preparation requirement.

Slurry Prep Systems are compatible with Flash, MPLC and HPLC DAC Columns

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Prepare for Column Packing in 7 Easy Steps Fill SPS vessel with slurry buffer as recommended by the media manufacturer

Add media from your supplier’s containers

Gently mix the media into a slurry with the agitator

Allow the media to briefly settle in the vessel for de-fining

Decant fines from the supernatant; repeat steps 4 and 5 as necessary

Add more slurry buffer and recirculate vessel to reslurry media

Connect to your empty column and charge the slurry using the slurry transfer pump

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Documentation for Slurry Prep SystemsTo support your clinical and commercial cGMP manufacturing needs, all Slurry Prep Systems are provided with a GMP documentation package. The package includes the following:

» User Manual

» Pressure Test Certificate for vessel

» Spare parts list

» Material certificates for wetted surfaces

» USP Class VI certificates for wetted seals

» BSE/TSE free certificates for product contact seals

Slurry Prep Systems are compatible with DAC LC Columns with size between

30 and 120 cm i.d.

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Contact Information

Ordering Information

Catalog No. Vessel Working Volume Pressure Rating Suitable AKB DAC LC Column Pairings (i.d. x L, cm)

SP100 100 L 1.4 bar 30 x 70, 35 x 50, 35 x 70, 40 x 50, 40 x 70, 45 x 50

SP200 200 L 1.4 bar 45 x 70, 50 x 50, 50 x 70, 60 x 50

SP350 350 L 1.4 bar 60 x 70, 80 x 50, 80 x 70

SP600 600 L 1.4 bar 80 x 70, 100 x 50, 100 x 70, 120 x 50

*Note: Customized volumes and configurations are available upon request.

For more information, please visit:www.ak-bio.com

© 2019 Asahi Kasei Bioprocess America, Inc. All rights reserved.

A reliable technical support network is available throughout North and South America, Europe and Asia. We offer an extendable 1-year warranty, service contracts and a personalized level of service for peace of mind and timely support when you need it.

Technical Support and Warranty Information

India and Southeast Asia

Mumbai, IndiaTel: +91-22-6710-3962Fax: +91-22-6710-3979

Email: [email protected]

East Asia and Oceania

Glenview, IL, USATel: +1-847-556-9700 Fax: +1-847-556-9701

Email: [email protected]

Europe

Cologne, GermanyTel: +49-221-995007-59Fax: +49-221-9950077-59

Email: [email protected]

North and South America

Glenview, IL, USATel: +1-847-556-9700 Fax: +1-847-556-9701

Email: [email protected]

China

Shanghai, ChinaTel: +86-(0)21-6391-6111Fax: +86-(0)21-6391-6686

Email: [email protected]