Custom particles

www.nlm.nih.gov

Preventing immune-response induced thrombosis*

*Lee, et. al. Prog Polym Sci, 1995**Storm, et. al. Adv. Drug. Del. Revs, 1995***Jonas, et. al. Nano Letters, 2008, van Vlerken, et. al. Pharm Rsch, 2007

Targeted uptake of genes, drugs by specific cells, stimuli-responsive materials***

Polymer design parameters for drug delivery

Rdrug

Hbrush

Rprotei

n

σ

σRg2

Goal: find the polymer-induced

repulsion as a function of:

Rprotei

nRdrug Hbrush

Rdrug

0.93 2.25

protein drug

drug g brush

R R DF ~ ln

R R H

Trombly and Ganesan, JPS(B), 2009

Drug-protein project

Extensions

Trombly and Ganesan, JCP, 2010 (accepted)

Polyethylene glycol

hydrogen bonding

Result: two phases

Design of neutral surfacesRandom copolymer brush

Mansky, et al, Science, 1997f

A B

Model-SCFTw(r)

q(r,s)

)s,(q)(w)s,(q6Nb

s)s,(q 2

2

rrrr

qc(r,s)

w(r) = vρ(r)

)])(w[;(Qlnd)(wdv21

)](w[F 2 rrrrrr

Energetic Entropic

Blood protein

Polymer-coated drug

ρ(r)

Bispherical coordinates

q 0

Fredrickson, “The Equilibrium Theory of Inhomogeneous Polymers,” 2005