Protein Structure

Biology/Chemistry of Protein Structure

Primary

Secondary

Tertiary

Quaternary

Assembly

Folding

Packing

Interaction

S T

R U

C T

U R

E P R O

C E S S

Primary Structure - Sequence

FOLDING

Basic Secondary structureBasic Secondary structure

α-helix β-sheet

Secondary structures, α-helix and β-sheet, have regular hydrogen-bonding patterns.

Tertiary structure

Quaternary structure

1’ > 2’ > 3’ > 4’ > …

X - Ray

X-ray Diffraction Pattern for a Protein

X-Ray

NMR – there is no right answer

THE database of experimentally-derived structures of proteins, nucleic acids, and complexes

•Access to structural information•Visualization•Analysis

Experimental Methods: X-Ray Crystallography NMR more…

Macromolecules: Proteins Nucleic acids Carbohydrates

Protein-nucleic acid complexes Protein-carbohydrate complexes

PDB Growth and Content

PDB Homepage

An Example – 2ARA

Search Methods

Advanced Search

Sequence Search

Example Results