Protein Structure
description
Transcript of Protein Structure
Protein StructureFall 2011
Aaron Zampaglione
Protein Fold
Rossmann Fold
Protein Domains (Folds)
Four main classes:All-αAll-βα+βα/β(Membrane and cell surface proteins and peptides)(Small proteins)
All-α
The lone helix The helix-turn-helix motif The four-helix bundle Helix-helix packing
All-β
β sandwiches and β barrels Up-and-down antiparallel β sheets β-propellors β-trefoils β-Helix
α+β
Bacterial and mammalian pancreatic ribonucleases
Lysozome Ubiquitin
α/β
α/βhorseshoe α/βbarrels
beta-alpha-beta
Motif
Structural Motifs
β-α-β β-hairpin Greek Key Helix-Loop-Helix (HLH)
Helix-Turn-Helix (HTH) Leucine Zipper Psi-loop Zinc Finger
β-α-β Motif
β-hairpin Motif
Greek Key Motif
Helix-Loop-Helix (HLH) Motif
Helix-Turn-Helix (HTH) Motif
Leucine Zipper Motif
Psi-loop Motif
Zinc Finger Motif
Biology Workbench
Protein Tools Alignment Tools Structure Tools
http://workbench.sdsc.edu
Additional Tools
CDART (Motifs) http://www.ncbi.nlm.nih.gov/Structure/lexington/lexington.cgi?cmd=
rps PROSITE (Motifs)
http://prosite.expasy.org/cgi-bin/prosite/prosite-list.pl SCOP (Structure)
http://scop.mrc-lmb.cam.ac.uk/scop CATH (Structure)
http://www.cathdb.info
References
Expasy. (1999). Tertiary Protein Structure and folds. Retrieved 08 30, 2011, from Expasy: http://swissmodel.expasy.org/course/text/chapter4.htm
Karadaghi, S. (2011). Protein Domains. Retrieved 08 30, 2011, from Protein Structures: http://www.proteinstructures.com/Structure/Structure/protein-domains.html
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