Pegylated interferon-α, ribavirin, and rituximab combined ...
Peginterferon-α2a/ribavirin
1
Reactions 1021 - 2 Oct 2004 Peginterferon-α2a/ribavirin IgA nephropathy: case report A 54-year-old man developed IgA nephropathy during treatment with peginterferon-α-2a and ribavirin for chronic hepatitis C infection. Nine days after starting treatment with SC peginterferon- α-2a 180 µg/week and ribavirin 600mg twice daily, the man presented with macroscopic haematuria. Urinalysis revealed > 1000 × 10 6 /L RBCs and > 1000 × 10 6 /L WBCs, and a 24 hour urine collection revealed proteinuria of 1.78 g/day. His serum creatinine level had increased from 0.09 mmol/L at baseline to 0.19 mmol/L, his haemoglobin level had decreased from 172 to 140 g/L and he had a bilirubin level of 44 mmol/L, a lactate dehydrogenase level of 741 U/L and a haptoglobin level of < 0.06 g/L. A kidney biopsy revealed acute tubular necrosis, glomerular IgA deposition and mild mesangial proliferation, consistent with IgA nephropathy. Peginterferon-α-2a and ribavirin were discontinued and the man’s symptoms gradually resolved. Gordon A, et al. Combination pegylated interferon and ribavirin therapy precipitating acute renal failure and exacerbating IgA nephropathy. Nephrology Dialysis Transplantation 19: 2155, No. 8, Aug 2004 - Australia 800987447 1 Reactions 2 Oct 2004 No. 1021 0114-9954/10/1021-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Peginterferon-α2a/ribavirin
Reactions 1021 - 2 Oct 2004
Peginterferon-α2a/ribavirin
IgA nephropathy: case reportA 54-year-old man developed IgA nephropathy during
treatment with peginterferon-α-2a and ribavirin for chronichepatitis C infection.
Nine days after starting treatment with SC peginterferon-α-2a 180 µg/week and ribavirin 600mg twice daily, the manpresented with macroscopic haematuria. Urinalysis revealed> 1000 × 106/L RBCs and > 1000 × 106/L WBCs, and a 24 hoururine collection revealed proteinuria of 1.78 g/day. His serumcreatinine level had increased from 0.09 mmol/L at baseline to0.19 mmol/L, his haemoglobin level had decreased from 172to 140 g/L and he had a bilirubin level of 44 mmol/L, a lactatedehydrogenase level of 741 U/L and a haptoglobin level of< 0.06 g/L. A kidney biopsy revealed acute tubular necrosis,glomerular IgA deposition and mild mesangial proliferation,consistent with IgA nephropathy.
Peginterferon-α-2a and ribavirin were discontinued and theman’s symptoms gradually resolved.Gordon A, et al. Combination pegylated interferon and ribavirin therapyprecipitating acute renal failure and exacerbating IgA nephropathy. NephrologyDialysis Transplantation 19: 2155, No. 8, Aug 2004 - Australia 800987447
1
Reactions 2 Oct 2004 No. 10210114-9954/10/1021-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
