Oncology Brochure 1 Page Final

1
In Vitro Cell culture & screening In Vivo Xenogra1 models Ex Vivo μCT scanning & histology Oncology Services TumorScreen TM (60+ Cell Lines) Prolifera:on High sensi:vity CaspaseScreen (60+ Cell Lines) Apoptosis 24 hour or custom assay ComboScreen TM 5x5 or custom matrix Combina:on index & Bliss analysis 3D Screen for in vivolike gene expression Prolifera:on Custom cell lines Ability to translate tumor cell lines into xenograE studies MulGple xenograE models for prostate, lung, colon, and liver cell lines Other tumor types in development Custom models available OpGcal imaging & orthotopic models coming soon HighresoluGon imaging & analysis of tumor vasculature Tumor volume and surface area Vessel volume, radius, tortuosity, branching, density, and distribu:on depth Proprietary AltaBlu TM imaging agent for 3D vascular analysis Low toxicity Safer, easier to work with, and permits more consistent perfusions MulGple oncology and angiogenic markers of tumors for analysis using immunohistochemistry (IHC) Vessel Radius 0 200 400 600 800 1000 1200 0 10 20 Tumor Volume (mm 3 ) Days Post Treatment HT29 XenograE Control Paclitaxel Expert staff with 20 years experience 8+ years of CRO experience, serving over 100 oncology clients [email protected] www.NumiraBio.com Tel: 8013200682 3D Culture All assays performed with a 9concentra6on curve in quadruplicate with luminescent readout at 72hrs unless otherwise specified.

Transcript of Oncology Brochure 1 Page Final

Page 1: Oncology Brochure 1 Page Final

In  Vitro    Cell  culture  &  screening  

In  Vivo    Xenogra1  models  

Ex  Vivo  μCT  scanning  &  histology  

Oncology  Services  

§  TumorScreenTM  (60+  Cell  Lines)  •  Prolifera:on  •  High  sensi:vity  

§  CaspaseScreen  (60+  Cell  Lines)  •  Apoptosis  •  24  hour  or  custom  assay  

§  ComboScreenTM  

•  5x5  or  custom  matrix  •  Combina:on  index  &  Bliss  analysis  

§  3D  Screen  for  in  vivo-­‐like  gene  expression  •  Prolifera:on  •  Custom  cell  lines  

§  Ability  to  translate  tumor  cell  lines  into  xenograE  studies  

§ MulGple  xenograE  models  for  prostate,  lung,  colon,  and  liver  cell  lines  

§ Other  tumor  types  in  development  

§  Custom  models  available  

§ OpGcal  imaging  &  orthotopic  models  coming  soon  

§  High-­‐resoluGon  imaging  &  analysis  of  tumor  vasculature  •  Tumor  volume  and  surface  area  •  Vessel  volume,  radius,  tortuosity,  branching,  density,  and  distribu:on  depth  

§  Proprietary  AltaBluTM  imaging  agent  for  3D  vascular  analysis  •  Low  toxicity  •  Safer,  easier  to  work  with,  and  permits  more  consistent  perfusions  

§ MulGple  oncology  and  angiogenic  markers  of  tumors  for  analysis  using  immunohistochemistry  (IHC)  

Vessel  Radius  

0  

200  

400  

600  

800  

1000  

1200  

0   10   20  

Tumor  Volum

e  (m

m3 )  

Days  Post  Treatment  

HT-­‐29  XenograE  

Control  

Paclitaxel  

§ Expert  staff  with  20  years  experience    § 8+  years  of  CRO  experience,  serving  over  100  oncology  clients  

[email protected]                                                                                                      www.NumiraBio.com                                                                                                                                  Tel:  801-­‐320-­‐0682  

3D  Culture  

All  assays  performed  with  a  9-­‐concentra6on  curve  in  quadruplicate  with  luminescent  readout  at  72hrs  unless  otherwise  specified.