NEWS 06www.biohellenika.gr

Biohellenika's laboratories, in palsy and autism is a promising

collaboration with University and target for autologous stem cell

private sector clinics in Greece and therapy.

neighboring countries are presently In the case of cerebral palsy, it is supporting several stem cell clinical presently widely accepted that trials that are under development. autologous cord blood stem cell

Ischemic brain injury that has been administration may be the only

implicated in ailments, like cerebral hope for cure. n page 04 n page 06

July 2010

Athanasios is the fourth child in the family and his parents decided to store his umbilical

cord blood stem cells in order to protect the future health of their growing family.

Athanasios was born overweight and therefore his mother had a difficult labor. During

delivery his brain became hypoxic for several minutes because the middle cerebral artery

was clotted. Athanasios had early indications of cerebral palsy and his family did

everything possible to cure him.

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Biohellenika's laboratories support autologous stem cell therapy CLINICAL TRIALS

BIOHELLENIKA and TAK-EIE Laboratories supported the first stem cell therapy for autism in Greece

The first autism stem cell therapy

was possible in Greece with a

collaboration of specialized doctors

and the laboratory support of

Biohellenika TAK EIE.

THE SECOND CEREBRAL PALSY CHILD WHO HAS STORED UMBILICAL CORD BLOOD STEM CELLS IN BIOHELLENIKA HAS BEEN TREATED AT DUKE UNIVERSITY HEMATOLOGY CLINIC

Biohellenika's Laboratories in Athens (TAKE EIE) are the first ministry of health licensed family cord blood bank in Greece

Stem Cells and Hair Loss (Alopecia)

New data for the use of cord blood placenta derived stem cells

Biohellenika's Services

The Advantages of Biohellenika

Stem cells for type I diabetes therapy

Non-haematological uses of cord blood stem cells

Potential role of dental stem cells in the cellular therapy of cerebral ischemia

NEWS02

Biohellenika is the first company in Greece which operates under the guidelines of ISO 15189, and is accredited as medical laboratory on 08/02/2008 with the 410/8/2/2008 accreditation certificate by the National Accreditation Forum S.A. (ESYD), granted for procedures followed and quality testing of umbilical cord blood during the collection of stem cells. With this certification, Biohellenika is accredited according to ISO 15189:2007, special for medical laboratories, for nucleated cell measurement, hematopoietic stem cell viability and sterility testing, including aerobic, anaerobic bacteria and fungi. This certificate is valid until 2012 as long as the facility's operations comply with the above guidelines during regular ESYD inspections.

The Accreditation is recently expanded to the Molecular Diagnostics Laboratory that is established in Biohellenika's facilities and provides genetic analysis of inherited diseases, cardiovascular diseases, infertility and HPV tests.

The National Accreditation Forum (ESYD) is a full member of the International Laboratory Accreditation Cooperation (ILAC) since 2004, of the European Cooperation for Accreditation EA since 2005, and of the International Accreditation Forum (IAF-MRA) since 2006.

The international identity of ESYD gives the perspective of the parity and mutual recognition of accreditation between countries. Today Biohellenika is the first company in Greece whose laboratories are accredited by a national independent organization for measurements and quality control procedures followed during stem cell collection from umbilical cord blood.

Biohellika currently is being evaluated for the international accreditation by the American Association of Blood Banks (AABB).

03NEWS

he laboratories of TAK EIE, a joint venture

between Hellenic National Research

Foundation and Biohellenika Biotechnology Applications S.A. is the first cord blood bank

that Greek Ministry of Health administered a license.

TAK EIE laboratories are serving all samples Biohellenika

collects from Athens, southern Greece and Aegean

islands. Biohellenika owns two laboratories in Greece,

one in Athens (TAKEIE) and one in Thessaloniki, in order

to improve the stored stem cell quality by minimizing

the time gap between birth and stem cell processing.

The licensing of its laboratories will enable Biohellenika

to establish medical applications locally and abroad, in

collaboration with scientists, medical doctors and

parents, who trusted the name Biohellenika in these

countries and have already banked the precious stem

cells of their children in Biohellenika.

NEW SERVICEBiohellenika has developed the technology and now

provides the parents the storage of mesenchymal

stem cells from the total length of the umbilical

cord. With this method, all mesenchymal stem cells

of the umbilical cord are collected and stored and

therefore no cell cultures will be needed in the

future, which would be applied if the number of

stem cells is not enough, with an extra cost.

This service is added to the classical collection of

umbilical cord, by the puncture of the umbilical cord

vein and to the placenta drainage and provides the

family all the possible hematopoietic and

mesenchymal stem cells that can be collected

during labor. Given that, stem cells of umbilical cord

and placenta are superior in quality than any other

source of stem cells, Biohellenika provides the child

and the family, the greatest possible quantity and

quality of stem cells.

DYNAMIC EXPANSION OF BIOHELLENIKA TO NEIGBORING COYNTRIES Biohellenika expanded its activities to Romania,

through Biohellenica Ro., to Bulgaria through

Biohellenika Bg. and Servia through Beo Stem. A lot

of parents from the neighboring countries select

Biohellenika to store their children's stem cells.

Biohellenika Bulgaria announced its opening in thBulgaria with a press conference on 13 of May and

participated to the Annual Meeting of Bulgaria

Obstetrics-Gynecology Society. The Meeting took

place in Promorie, from 24-26 Jun 2010, and Dr.

Kouzi-Koliakou, the scientific director of

Biohellenika, presented a topic about Stem cells

applications and the new perspectives.

Also, Dr. Koliakou on 14/5/2010 represented

Biohellenika in the Annual Romanian Dentists

meeting in Brasov, where she presented The dental

pulp stem cells and its applications.

Biohellenika S.A. is the first Accredited by ESYD (National Accreditation Forum) Stem Cell Cryopreservation Company

Biohellenika's Laboratories in Athens (TAKE EIE)ARE THE FIRST MINISTRY OF HEALTH LICENSED FAMILY CORD BLOOD BANK IN GREECE

. 410

ACCREDITATION CERTIFICATE

The Hellenic Accreditation System S.A. (ESYD), as the national accreditation body ofGreece, in accordance with the Law 3066/2002,

ACCREDITS

the

Laboratoryof the

BIOHELLENIKA S.A.

in Thessaloniki, Greece

Athens, February 8, 2008

. Papaioannou Chairman of ESYD

Hellenic Accreditation System S.A.

65, Georgikis Scholis Avenue, 57001 Thessaloniki

ZEDA building

Tel.: 0030 2310.474.282, 2310.474.284, Fax: 0030 2310.474.285

E-mail: info@biohellenika.gr, www.biohellenika.gr

NEWSQuarterly publication of Biohellenika

Nr 06

Biohellenika S.A. is responsible for the published material in this issue.

All rights reserved. No part of this issue may be reproduced without permission of the publisher.

the biggest greek stem cell cryopreservation institution

Biohe enikaBIOTECHNOLOGY COMPANY

NEWS02

Biohellenika is the first company in Greece which operates under the guidelines of ISO 15189, and is accredited as medical laboratory on 08/02/2008 with the 410/8/2/2008 accreditation certificate by the National Accreditation Forum S.A. (ESYD), granted for procedures followed and quality testing of umbilical cord blood during the collection of stem cells. With this certification, Biohellenika is accredited according to ISO 15189:2007, special for medical laboratories, for nucleated cell measurement, hematopoietic stem cell viability and sterility testing, including aerobic, anaerobic bacteria and fungi. This certificate is valid until 2012 as long as the facility's operations comply with the above guidelines during regular ESYD inspections.

The Accreditation is recently expanded to the Molecular Diagnostics Laboratory that is established in Biohellenika's facilities and provides genetic analysis of inherited diseases, cardiovascular diseases, infertility and HPV tests.

The National Accreditation Forum (ESYD) is a full member of the International Laboratory Accreditation Cooperation (ILAC) since 2004, of the European Cooperation for Accreditation EA since 2005, and of the International Accreditation Forum (IAF-MRA) since 2006.

The international identity of ESYD gives the perspective of the parity and mutual recognition of accreditation between countries. Today Biohellenika is the first company in Greece whose laboratories are accredited by a national independent organization for measurements and quality control procedures followed during stem cell collection from umbilical cord blood.

Biohellika currently is being evaluated for the international accreditation by the American Association of Blood Banks (AABB).

03N