Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing...

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Transcript of Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing...

  • Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC 2-1 SubunitAssunta Senatore, Simona Colleoni, Claudia Verderio, Elena Restelli, Raffaella Morini, StevenB. Condliffe, Ilaria Bertani, Susanna Mantovani, Mara Canovi, Edoardo Micotti, Gianluigi Forloni, AnnetteC. Dolphin, Michela Matteoli, Marco Gobbi, Roberto ChiesaNeuronVolume 74, Issue 2, Pages 300-313 (April 2012) DOI: 10.1016/j.neuron.2012.02.027Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure1 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure2 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure3 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure4 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure5 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure6 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure7 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

  • Figure8 Neuron2012 74, 300-313DOI: (10.1016/j.neuron.2012.02.027) Copyright 2012 Elsevier Inc. Terms and Conditions

    Tg(PG14) Mice Develop Deficits in Motor and Balance Coordination before Cerebellar Degeneration

    (A) Groups of 615 Tg(WT), 712 Tg(PG14) mice, and 617 non-Tg littermates were tested on a Rotarod at the ages indicated. Each mouse was tested three times. Bars indicate the mean SEM latency to fall (s); p< 0.01, p