Mucosal Immunity of the Intestine: Homeostasis and Inflammation · 2018. 1. 17. · Gut Mucosal...
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MAdCAM-1 TACI IL-12 Rβ2 CRTAM IL-1RI A2BAR CD90 IL-17 RB IL-17 RB IL-23 R IL-23 R TSLP R TSLP R TSLP R IL-1RI IL-7 Rα/CD127 CD117/c-Kit CX 3 CR1 CD14 Siglec-3/CD33 FCAR/CD89 IL-2 Rβ TSLP R CXCR6 CCR7 CCR6 CCR6 CCR6 pIgA CCR6 CCR6 IL-1RI gp130 Common γ chain IL-12 Rβ1 IL-21 R IL-6 Rα IL-23R CRTAM TGF-β RI IGSF4A IL-1 RAcP Integrin α4β7 Integrin α4β7 Integrin αE/CD103 Integrin αE/CD103 Integrin αE/CD103 Integrin αE/CD103 Integrin αE/CD103 Integrin αM/CD11b Integrin αM/CD11b CCR7 CCR7 Integrin αE/CD103 Integrin αE/CD103 Integrin αE/CD103 TLR 2,4,5,7/8,10 sIgA Immune Complexes CLEC9a, DCIR, DC-SIGN, SIGNR1 CCR7 TLR2, TLR4, TLR5 TLR2, TLR4, TLR5 CX3CR1 CX3CR1 CX3CR1 CCR10 CXCR5 GITR KLRG1 CD25/IL-2 Rα CXCR5 CXCR5 ICOS Ligand CD84 NTB-A B7-H1 B7-H2 PD-L2 CD40 CD40 CXCL13/BLC/BCA-1 IL-10 TGF-β IL-9 IL-10 IL-35 TGF-β IL-6 IL-9 IL-17A IL-17F IL-21 IL-22 IL-26 TNF-α iNOS TNF-α IL-6 IL-12 IL-23 Osteopontin EN-RAGE IL-12 IL-23 IL-6 IL-7 IL-17E Retinoic Acid Secretogranin V TGF-β TSLP Apolipoprotein A1 APRIL BAFF CCL9/MIP-1γ CCL20/MIP-3α Clusterin CXCL7/NAP-2 CXCL8/IL-8 Epithelium-Derived Homeostatic Factors APRIL BAFF CCL2/MCP-1 CCL5/RANTES CCL20/MIP-3α Clusterin CXCL8/IL-8 α-Defensins FABP5 IL-15 Reg3A Retinoic Acid Secretogranin V SPLA2/PLA2G2A TGF-β TSLP TRAIL CCL5/RANTES CCL11/Eotaxin IL-4 IL-5 IL-13 IL-1 IL-6 Nitric Oxide ROS TNF-α IFN-γ Perforin TNF-α IFN-γ Perforin TNF-α IFN-γ IL-17 IL-22 Granzymes IFN-γ Perforin TNF-α Granzymes IFN-γ Perforin TNF-α APRIL BAFF TGF-β CXCL13/BLC/BCA-1 IL-5 IL-6 Retinoic Acid CCL5/RANTES CCL11/Eotaxin GM-CSF IL-4 Leukotriene C4 PAF Protectin D1 Resolvin E3 CCL5/RANTES CCL11/Eotaxin GM-CSF IL-4 Leukotriene C4 PAF Protectin D1 Resolvin E3 IL-9 IL-10 IL-21 IL-10 IL-13 IL-22 IL-17A IL-22 IL-10 IL-35 TGF-β GM-CSF IFN-γ IL-17A IL-22 IFN-γ IL-17 IL-22 Amphiregulin IL-4 IL-5 IL-9 IL-13 Granzyme B IL-10 Retinoic Acid TGF-β BTLA CD28 CD40 CTLA-4 ICOS PD-1 CD84, NTB-A, SLAM CD21 CXCR4 CXCR3 CCR10 CCR7 CD90 CD117/c-kit IL-1RI IL-23 R CD25/IL-2 Rα NCAM-1/CD56 IL-7 Rα/CD127 IL-7 Rα/CD127 PSGL-1 FCAR/CD89 FCAR/CD89 CCR2 CXCR2 CXCR1 P-Selectin TfR TfR ILC1 ILC1 Cytotoxic NK Cell Cytotoxic NK Cell CD103 + Dendritic Cell CD103 + Dendritic Cell CD103 + Dendritic Cell CD103 + Dendritic Cell ILC3 ILC3 Treg (Suppressed) Treg (Suppressed) ILC2 (Suppressed) ILC2 (Suppressed) Plasma Cell Plasma Cell Plasmablast Plasmablast Follicular T Helper Cell Follicular T Helper Cell B Cell B Cell Follicular T Regulatory Cell Follicular T Regulatory Cell Th17 Th17 CX3CR1 + Dendritic Cell CX3CR1 + Dendritic Cell Macrophage Macrophage Pathogenic Bacteria Pathogenic Bacteria Lumen of Small Intestine Lumen of Small Intestine Homeostasis Homeostasis Inflammation Inflammation Basement Membrane Basement Membrane Treg Treg Th22 Th22 Th9 Th9 LTi LTi Plasma Cell Plasma Cell Paneth Cells Paneth Cells Goblet Cell Goblet Cell Goblet Cell Goblet Cell Goblet Cell Goblet Cell Macrophage Macrophage Enterocytes Enterocytes Mucous Layer Mucous Layer M Cell M Cell M Cell M Cell CD103 + Dendritic Cell CD103 + Dendritic Cell CX3CR1 + Dendritic Cell CX3CR1 + Dendritic Cell CX3CR1 + Dendritic Cell CX3CR1 + Dendritic Cell Follicular Dendritic Cell Follicular Dendritic Cell Peyer’s Patch Peyer’s Patch Submucosa Submucosa Muscularis Externa Muscularis Externa Eosinophil Eosinophil Monocyte Monocyte Breg Breg ILC2 ILC2 Trm Trm ILC3 ILC3 Immunoregulatory NK Cell Immunoregulatory NK Cell Eosinophil Eosinophil CD103 + Dendritic Cell CD103 + Dendritic Cell Monocyte Monocyte Neutrophil Neutrophil Neutrophils Neutrophils M Cell M Cell CX3CR1 + Dendritic Cell CX3CR1 + Dendritic Cell TLR4 TLR4 TLR4 TLR4 TLR4 TLR4 TLR4 TLR4 CD163 sIgA sIgA sIgA sIgA sIgA CD68 Fcγ RIII/CD16 CX3CR1 CX3CR1 CX3CR1 Connexin 43 Connexin 43 DC-SIGN DC-SIGN SIRPα CD47 NKp30, 44, 46 NKp30, 44, 46 CD94 DNAM1 NKG2D CX3CR1 CXCR1 FCAR/CD89 MAdCAM-1 CCR2,5,7 IL-12 Rβ1 CD19 MAdCAM-1 BCMA TNF R CCR9 CCR10 IgA Integrin α4β7 TACI BCMA BAFF R Integrin α4β1 Integrin αLβ2 Lymphotoxin α 1 β 2 ICAM-1 VCAM-1 TLR5 Fcγ RII/CD32 Fcγ RIII/CD16 BTLA CD28 CD35 CD35 CD21 CD21 TLR4 TLR4 TLR2 CD36 MAdCAM-1 CTLA-4 ICOS PD-1 Dectin-1 Dectin-1 DC-SIGN DC-SIGN NKG2D NKG2D CD69 CD69 Integrin α4β7 Integrin α4β7 CX3CR1 CX3CR1 Connexin 43 Connexin 43 Connexin 43 Connexin 43 Connexin 43 Connexin 43 Antigen Antigen CCR10 TREM2 plgR plgR CD163 TLR4 Siglec-5 Siglec-5 TLR4 TLR4 TLR4 TLR4 TLR4 TLR4 DC-SIGN DC-SIGN CD68 CD64 CD64 CCR6 IL-17 RB CCR4 CCR9 CCR4 CCR6 CCR10 TLR2 BCMA TSLP R ST2 CD25/IL-2 Rα CD25 GITR ICOS DR3 IL-7 Rα/CD127 IL-7 Rα/CD127 CD69 Integrin αE/CD103 CD21 TLR4 Siglec-2/CD22 IL-21 R IL-27 Rα/WSX-1/TCCR TLR4 TLR2 IL-15 Rβ sIgA sIgA sIgA sIgA Commensal Bacterium Innate IEL Innate IEL Adaptive IEL Adaptive IEL Anti-Microbial Peptides Anti-Microbial Peptides Anti-Microbial Peptides Enterocyte Enterocyte Enterocyte Enterocyte Drainage to Mesenteric Lymph Nodes (CCR7-Dependent) Release to Circulation Drainage to Mesenteric Lymph Nodes (CCR7-Dependent) Drainage to Mesenteric Lymph Nodes (CCR7-Dependent) Gut Mucosal Homing From Circulation (CCR9 and Integrin α4β7- Dependent) Inflammatory Leukocyte Infiltration Anti-microbial Peptides CAMP CRISP-3 MMP-9 Leukotrienes Anti-microbial Peptides CAMP CRISP-3 MMP-9 Leukotrienes Myeloperoxidase Neutrophil Elastase ROS Proteinase 3 Myeloperoxidase Neutrophil Elastase ROS Proteinase 3 TGF-β RII IL-10 IL-22 Retinoic Acid TSLP IL-10 IL-22 Retinoic Acid TSLP Epithelium-Derived Inflammatory Mediators CXCL13/BLC/BCA-1 IL-4 IL-21 TGF-β CXCL13/BLC/BCA-1 IL-4 IL-21 TGF-β Class Switch to IgA Mucosal Immunity of the Intestine: Homeostasis and Inflammation Small Intestine NOTE: This poster conveys a general overview and should be considered neither comprehensive nor definitive. The details of this information are understood to be subject to interpretation. © R&D Systems 2015 Global [email protected] [email protected] USA TEL 800 343 7475 Canada TEL 855 668 8722 Europe | Middle East | Africa TEL +44 (0)1235 529449 China TEL +86 (21) 52380373 Learn more | rndsystems.com/mucosalposter
Transcript of Mucosal Immunity of the Intestine: Homeostasis and Inflammation · 2018. 1. 17. · Gut Mucosal...
MAdCAM-1
TACI
IL-12 Rβ2
CRTAM
IL-1RIA2BAR
CD90
IL-17 RB
IL-17 RB
IL-23 R
IL-23 RTSLP R
TSLP R
TSLP R
IL-1RIIL-7 Rα/CD127
CD117/c-Kit
CX3CR1CD14
Siglec-3/CD33FCAR/CD89
IL-2 Rβ
TSLP R
CXCR6
CCR7
CCR6
CCR6
CCR6
pIgA
CCR6
CCR6
IL-1RI
gp130
Common γ chain
IL-12 Rβ1
IL-21 R
IL-6 Rα
IL-23R
CRTAM
TGF-β RI
IGSF4A
IL-1 RAcP
Integrin α4β7
Integrin α4β7
Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
Integrin αM/CD11bIntegrin αM/CD11b
CCR7CCR7
Integrin αE/CD103
Integrin αE/CD103Integrin αE/CD103
TLR 2,4,5,7/8,10 sIgA ImmuneComplexes
CLEC9a, DCIR, DC-SIGN, SIGNR1
CCR7
TLR2, TLR4, TLR5TLR2, TLR4, TLR5
CX3CR1
CX3CR1
CX3CR1
CCR10
CXCR5GITR
KLRG1
CD25/IL-2 Rα
CXCR5
CXCR5
ICOS LigandCD84
NTB-A
B7-H1
B7-H2PD-L2
CD40
CD40
CXCL13/BLC/BCA-1IL-10TGF-β
IL-9IL-10IL-35TGF-β
IL-6IL-9IL-17AIL-17F
IL-21IL-22IL-26TNF-α
iNOSTNF-α
IL-6IL-12IL-23Osteopontin
EN-RAGEIL-12IL-23
IL-6IL-7IL-17ERetinoic AcidSecretogranin VTGF-βTSLP
Apolipoprotein A1APRILBAFFCCL9/MIP-1γCCL20/MIP-3αClusterinCXCL7/NAP-2CXCL8/IL-8
Epithelium-Derived Homeostatic Factors
APRILBAFFCCL2/MCP-1CCL5/RANTESCCL20/MIP-3αClusterinCXCL8/IL-8α-Defensins
FABP5IL-15Reg3ARetinoic AcidSecretogranin VSPLA2/PLA2G2ATGF-βTSLP
TRAILCCL5/RANTESCCL11/EotaxinIL-4IL-5IL-13
IL-1IL-6Nitric OxideROSTNF-α
IFN-γPerforinTNF-α
IFN-γPerforinTNF-α
IFN-γIL-17IL-22
GranzymesIFN-γPerforinTNF-α
GranzymesIFN-γPerforinTNF-α
APRILBAFFTGF-β
CXCL13/BLC/BCA-1IL-5IL-6Retinoic Acid
CCL5/RANTESCCL11/EotaxinGM-CSFIL-4Leukotriene C4PAFProtectin D1Resolvin E3
CCL5/RANTESCCL11/EotaxinGM-CSFIL-4Leukotriene C4PAFProtectin D1Resolvin E3
IL-9IL-10IL-21
IL-10IL-13IL-22
IL-17AIL-22
IL-10IL-35TGF-β
GM-CSFIFN-γIL-17AIL-22
IFN-γIL-17IL-22
AmphiregulinIL-4IL-5IL-9IL-13
Granzyme B
IL-10Retinoic AcidTGF-β
BTLA
CD28
CD40
CTLA-4
ICOS
PD-1
CD84, NTB-A, SLAM
CD21
CXCR4
CXCR3
CCR10
CCR7
CD90
CD117/c-kit
IL-1RI
IL-23 R
CD25/IL-2 RαNCAM-1/CD56
IL-7 Rα/CD127
IL-7 Rα/CD127PSGL-1
FCAR/CD89
FCAR/CD89
CCR2
CXCR2
CXCR1
P-Selectin
TfRTfR
ILC1ILC1
CytotoxicNK Cell
CytotoxicNK Cell
CD103+
Dendritic CellCD103+
Dendritic Cell
CD103+
Dendritic CellCD103+
Dendritic Cell
ILC3ILC3
Treg(Suppressed)
Treg(Suppressed)
ILC2(Suppressed)
ILC2(Suppressed)
PlasmaCell
PlasmaCell
PlasmablastPlasmablast
Follicular T Helper
Cell
Follicular T Helper
CellB CellB Cell
FollicularT Regulatory
Cell
FollicularT Regulatory
Cell
Th17Th17
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
MacrophageMacrophage
PathogenicBacteria
PathogenicBacteria
Lumen of Small IntestineLumen of Small Intestine
HomeostasisHomeostasis InflammationInflammation
BasementMembraneBasementMembrane
TregTreg
Th22Th22
Th9Th9LTiLTi
Plasma CellPlasma Cell
Paneth CellsPaneth Cells
Goblet CellGoblet Cell
Goblet CellGoblet Cell Goblet CellGoblet Cell
MacrophageMacrophage
EnterocytesEnterocytesMucous LayerMucous Layer
M CellM Cell
M CellM Cell
CD103+
DendriticCell
CD103+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
CX3CR1+
DendriticCell
FollicularDendritic
Cell
FollicularDendritic
Cell Peyer’s PatchPeyer’s Patch
SubmucosaSubmucosaMuscularis ExternaMuscularis Externa
EosinophilEosinophil
MonocyteMonocyte
BregBreg
ILC2ILC2
TrmTrm
ILC3ILC3
ImmunoregulatoryNK Cell
ImmunoregulatoryNK Cell
EosinophilEosinophil
CD103+
Dendritic CellCD103+
Dendritic Cell
MonocyteMonocyte
NeutrophilNeutrophil
NeutrophilsNeutrophils
M CellM Cell
CX3CR1+
Dendritic CellCX3CR1+
Dendritic Cell
TLR4TLR4
TLR4TLR4
TLR4TLR4 TLR4TLR4
CD163
sIgA
sIgA
sIgA
sIgA
sIgA
CD68
Fcγ RIII/CD16
CX3CR1CX3CR1
CX3CR1
Connexin 43Connexin 43
DC-SIGNDC-SIGN
SIRPα
CD47
NKp30, 44, 46NKp30, 44, 46CD94
DNAM1
NKG2D
CX3CR1
CXCR1
FCAR/CD89
MAdCAM-1
CCR2,5,7
IL-12 Rβ1
CD19
MAdCAM-1
BCMA
TNF RCCR9
CCR10
IgA
Integrin α4β7
TACIBCMA
BAFF R
Integrin α4β1
Integrin αLβ2
Lymphotoxin α1β2
ICAM-1
VCAM-1TLR5
Fcγ RII/CD32
Fcγ RIII/CD16
BTLA
CD28
CD35
CD35 CD21
CD21
TLR4
TLR4
TLR2
CD36 MAdCAM-1
CTLA-4ICOS
PD-1
Dectin-1Dectin-1
DC-SIGNDC-SIGN
NKG2DNKG2D
CD69CD69
Integrin α4β7Integrin α4β7
CX3CR1CX3CR1
Connexin 43Connexin 43
Connexin 43Connexin 43
Connexin 43Connexin 43
AntigenAntigen
CCR10
TREM2
plgRplgR
CD163
TLR4
Siglec-5Siglec-5TLR4TLR4
TLR4TLR4
TLR4TLR4
DC-SIGNDC-SIGN
CD68 CD64CD64
CCR6IL-17 RB
CCR4
CCR9
CCR4
CCR6CCR10
TLR2
BCMA
TSLP R
ST2
CD25/IL-2 RαCD25
GITR
ICOSDR3 IL-7 Rα/CD127 IL-7 Rα/CD127
CD69
Integrin αE/CD103
CD21
TLR4
Siglec-2/CD22
IL-21 RIL-27 Rα/WSX-1/TCCR
TLR4
TLR2
IL-15 Rβ
sIgA
sIgA
sIgA
sIgA
CommensalBacterium
Innate IELInnate IEL
Adaptive IELAdaptive IEL
Anti-Microbial Peptides
Anti-Microbial PeptidesAnti-Microbial Peptides
EnterocyteEnterocyte
EnterocyteEnterocyte
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Release toCirculation
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Drainage to MesentericLymph Nodes
(CCR7-Dependent)
Gut Mucosal Homing From Circulation
(CCR9 and Integrin α4β7-Dependent)
Inflammatory LeukocyteInfiltration
Anti-microbial PeptidesCAMPCRISP-3MMP-9Leukotrienes
Anti-microbial PeptidesCAMPCRISP-3MMP-9LeukotrienesMyeloperoxidaseNeutrophil ElastaseROSProteinase 3
MyeloperoxidaseNeutrophil ElastaseROSProteinase 3
TGF-β RII
IL-10IL-22Retinoic AcidTSLP
IL-10IL-22Retinoic AcidTSLP
Epithelium-Derived Inflammatory Mediators
CXCL13/BLC/BCA-1IL-4IL-21TGF-β
CXCL13/BLC/BCA-1IL-4IL-21TGF-β
Class Switchto IgA
RnDSy-lu-2945
Mucosal Immunity of the Intestine: Homeostasis and Inflammation
Small Intestine
NOTE: This poster conveys a general overview and should be considered neither comprehensive nor definitive. The details of this information are understood to be subject to interpretation. © R&D Systems 2015
Global [email protected] [email protected] USA TEL 800 343 7475 Canada TEL 855 668 8722 Europe | Middle East | Africa TEL +44 (0)1235 529449 China TEL +86 (21) 52380373
Learn more | rndsystems.com/mucosalposter
