Minocycline effective in recurrent α1-antitrypsin-deficiency panniculitis
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Inpharma 1306 - 22 Sep 2001 ■ Minocycline successfully treated recurrent α1-antitrypsin-deficiency panniculitis in a 42-year-old woman, report researchers from Spain. The patient had to discontinue treatment with dapsone and prednisone due to adverse effects and monotherapy with deflazacort 22 mg/day failed to control her nodular lesions. When minocycline 100mg was coadministered every 12 hours, the lesions disappeared within 3 weeks. Minocycline was discontinued after 2 months and the deflazacort dosage was gradually reduced. However, while receiving deflazacort 15 mg/day, another lesion appeared. After recommencing minocycline 100mg every 12 hours, the lesion disappeared within 4 weeks. Seven months later, deflazacort was discontinued and the minocycline dosage was reduced to 100 mg/day for 19 months, then 100mg every 48 hours for a further 5 months, before discontinuing. Three months later, minocycline was recommenced because of a new lesion. Similarly, when minocycline was discontinued 2 years later, another lesion appeared within 3 months. Ginarte M, et al. Treatment of alpha-1-antitrypsin-deficiency panniculitis with minocycline. Cutis 68: 86-88, Aug 2001 800861948 1 Inpharma 22 Sep 2001 No. 1306 1173-8324/10/1306-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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Transcript of Minocycline effective in recurrent α1-antitrypsin-deficiency panniculitis
Inpharma 1306 - 22 Sep 2001
■ Minocycline successfully treated recurrentα1-antitrypsin-deficiency panniculitis in a 42-year-oldwoman, report researchers from Spain. The patienthad to discontinue treatment with dapsone andprednisone due to adverse effects and monotherapywith deflazacort 22 mg/day failed to control hernodular lesions. When minocycline 100mg wascoadministered every 12 hours, the lesionsdisappeared within 3 weeks. Minocycline wasdiscontinued after 2 months and the deflazacortdosage was gradually reduced. However, whilereceiving deflazacort 15 mg/day, another lesionappeared. After recommencing minocycline 100mgevery 12 hours, the lesion disappeared within 4weeks. Seven months later, deflazacort wasdiscontinued and the minocycline dosage was reducedto 100 mg/day for 19 months, then 100mg every 48hours for a further 5 months, before discontinuing.Three months later, minocycline was recommencedbecause of a new lesion. Similarly, when minocyclinewas discontinued 2 years later, another lesionappeared within 3 months.Ginarte M, et al. Treatment of alpha-1-antitrypsin-deficiency panniculitis withminocycline. Cutis 68: 86-88, Aug 2001 800861948
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Inpharma 22 Sep 2001 No. 13061173-8324/10/1306-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
