MASTERGRAFT® Granules & Mini Granules

• Medical grade polyporous resorbable ceramic granules– Each granule is composed of:

• 15% hydroxyapatite (HA)– Slow resorbing3

• 85% beta-tricalcium phosphate (β-TCP)– Fast resorbing3

• 80% interconnected porosity3

– 500 µm average pore diameter3

– 125 µm average interconnected diameter3

• 85:15 ratio chosen due to:– Long-term stability3

– Resorption rate3

3. Data On File

MASTERGRAFT® Granules in Extraction Socket Preservation – Proven Bone Formation7

• Study Design– Seven patients (ages 35 – 82

years)– Teeth extracted and

immediately grafted using MASTERGRAFT® Granules

– No primary closure– Implants placed at 4 – 5

months post-grafting

A. MASTERGRAFT® Granules placed into the extracted socket as a graft material. B. MASTERGRAFT® Granules were covered with a cellulose sponge. C. Bone core samples were taken from the grafted sites at 4 months after grafting. D. Installed implant into the grafted site at 4 months after grafting.

7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg. 2011;22(2):490-493.

• MASTERGRAFT® Granules in Human Extraction Sockets demonstrated:

• Osteoconductive scaffold for new bone formation

• Maintenance of space within the defect

• Support of new blood vessel formation

• Support of osteoclasts and osteoblasts for bone remodeling

• Effective for repairing bone defects

MASTERGRAFT® Granules in Extraction Socket Preservation Proven Bone Formation7

7. Wakimoto M, Ueno T, Hirata A, Iida S, Aghaloo T, & Moy PK. Histologic Evaluation of Human Alveolar Sockets Treated With an Artificial Bone Substitute Material. J of Cranio Surg. 2011;22(2):490-493.

Basic Bone Biology8

• Three main components

– Cells• Build, resorb and maintain

bone

– Organic Matrix• Collagen to resist fracture• Proteins (including BMP)

– Inorganic Matrix• Mineral (calcium phosphate) for

strength

Bone Tissue

Cells Matrix

Organic(DBM)

Inorganic(Mineral)

IRN7511-1.0-02

8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)

Bone Matrix8-9

Organic30%

Inorganic

Mineral70%

Composition of Bone

Type 1 Collagen

95%

Native Growth Factors

5%

Composition of Organic MatrixComposition of Inorganic Matrix

Calcium phosphate

8 Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)9. Einhorn. Biomechanics of Bone. Principles of Bone Biology (1996)

Protein Signals

Bone Grafting8

Extension of Bone Remodeling

• Assuming the right signals exist:– Osteoclasts break down old bone

• Release other signals to cells– Osteoblasts form new bone

• May reside in transplanted bone• Under right conditions, may recruit other cells

8. Marks. The Structure and Development of Bone. Principles of Bone Biology (1996)

Bone Graft Incorporation10

Vascularity– Graft porosity– Vascularity of

site/hostsite preparation

Bone Formation– Bone cells

– Osteoinduction

Graft/Host Union– Stability of the

construct– Contact area-Graft quantity

10. Kalfas. Principles of Bone Healing. Neurosurg Focus 10 (4): Article 1, (2001)

MASTERGRAFT® Granules & Mini Granules

• Medical grade polyporous resorbable ceramic granules– Each granule is composed of:

• 15% hydroxyapatite (HA)– Slow resorbing3

• 85% beta-tricalcium phosphate (β-TCP)– Fast resorbing3

• 80% interconnected porosity3

– 500 µm average pore diameter3

– 125 µm average interconnected diameter3

• 85:15 ratio chosen due to:– Long-term stability3

– Resorption rate3

3. Data on File