Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document /...
Transcript of Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document /...
![Page 1: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/1.jpg)
Aerosoler
Partikelegenskaper och toxikologi
![Page 2: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/2.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Partikel exponering
nm
μm
mm
Pollen
Damm etc
Sot
Messing 2011
Kol nanorör Thostensson et al 2001
Mer..
TiO2 Grassian et al 2007
![Page 3: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/3.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Partikel exponering och hälsoeffekter
• Vi har kunskap om att partiklar faktiskt medför hälsorisker • Smog, asbest, metallånga etc. • På gång med både in vitro och in vivo försök för att förstå
och kvantifiera partiklarnas toxikologi
![Page 4: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/4.jpg)
Lund University / Faculty / Department / Unit / Document / Date
www.av.se
![Page 5: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/5.jpg)
Lund University / Faculty / Department / Unit / Document / Date
www.av.se
![Page 6: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/6.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Dos - response
Waters et al 2009
![Page 7: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/7.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Dos - response
Waters et al 2009
![Page 8: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/8.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Vad kan vi veta om partiklarna?
Sot AuNP
Maria Messing, FTF
![Page 9: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/9.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Storleksberoende partikelegenskaper
Antal / Storlek
Storlek / Massa
Yta / Storlek
Teoretiska mått på partikelegenskaper
![Page 10: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/10.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Exempel på resultat
0,00E+00
2,00E+09
4,00E+09
6,00E+09
8,00E+09
1,00E+10
1,20E+10
0,00E+00
2,00E+06
4,00E+06
6,00E+06
8,00E+06
1,00E+07
1,20E+07
1,40E+07
0 50 100 150 200dm
/dlo
g(dp
) (ag
/cm
3)
dn/d
log(
dp) (
Nr#
/cm
3)
dm (nm)
HT 1625 dn/dlog(dp) HT 1575 dn/dlog(dp)
HT 1625dm/dlog(dp) HT 1575 dm/dlog(dp)
0,01
0,1
1
10
10 100
Mas
s (fg
)
dm (nm)
HT 1625 HT 1575 SD 3,7
SD 2,85 (20100630) SD 2,85 (20100701)
![Page 11: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/11.jpg)
Lund University / Faculty / Department / Unit / Document / Date
0,00E+00
5,00E-04
1,00E-03
1,50E-03
2,00E-03
2,50E-03
0 50 100 150 200
dA/d
log(
dp) (
cm2/
cm3)
dm (nm)
HT 1625 dA/dlog(dp)
0
0,5
1
1,5
2
2,5
3
3,5
4
4,5
5
0 20 40 60 80 100
X Dynamic shape factor
X:1 HT1625
X:2 HT1625
X:1 HT1575
X:2 HT1575
X:3 HT1575
X:1 SD 3,7
X:2 SD 3,7
X:1 SD 2,85 (20100630)
X:2 SD 2,85 (20100630)
X:1 SD 2,85 (20100701)
![Page 12: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/12.jpg)
Lund University / Faculty / Department / Unit / Document / Date
CPC
APM Aerosol particle mass analyzer
DMA Differential mobility analyzer
Condensation particle counter
DMA + CPC = SMPS Scanning mobility particle sizer
Mätutrustningen
![Page 13: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/13.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Uppställningen
DMA
APM CPC
Dator och kontroll box
![Page 14: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/14.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Partikeltoxikologi
• In vivo – Ex. Kammarexperiment • Försökspersoner exponeras för
karaktäriserad aerosol • Relevanta endpoints kvantifieras,
inflammationsmarkörer i kropppsvätskor etc.
![Page 15: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/15.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Partikeltoxikologi
• In vitro – Ex. Cellexponering • Insamling av partiklar för senare studier med
celler • Inflammationsmarkörer, genetiska analyser
![Page 16: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/16.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Framtiden är nu!
• ALI kammaren = Air Liquid Interface • Direkt deponering av partiklar direkt på
cellytor eller annat media • Undvika insamling och lagring av partiklar
Filter
Extraktion och lagring Eller?
![Page 17: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/17.jpg)
Lund University / Faculty / Department / Unit / Document / Date
ALI kammaren
Savi (2008)
![Page 18: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/18.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Savi (2008)
![Page 19: Lunds universitet i världsklass€¦ · Lund University / Faculty / Department / Unit / Document / Date Partikel exponering . nm . μ. m . mm Pollen Damm etc Sot . Messing 2011 .](https://reader033.fdocument.org/reader033/viewer/2022042318/5f0755227e708231d41c7628/html5/thumbnails/19.jpg)
Lund University / Faculty / Department / Unit / Document / Date
Tack för er uppmärksamhet!