Key named reactions in organic chemistry...1870 Key named reactions in organic chemistry 2000 by...

2
Knorr pyrrole synthesis L. Knorr Heterocycle formation Used to create substituted pyrroles through reacting an α-amino-ketone and a compound containing an electron-withdrawing group e.g. an ester to a carbonyl group. 1887 Gabriel synthesis S. Gabriel Nucleophilic substitution reactions Traditionally using potassium phthalimide transforms primary alkyl halides into primary amines. 1887 Reformatsky reaction S. Reformatsky Reactions involving carbonyl compounds Condenses aldehydes or ketones with α-halo esters using metallic zinc to form β-hydroxy-esters. 1893 Pomeranz-Fritsch reaction C. Pomeranz and P. Fritsch Heterocycle formation Condensation of benzaldehydes or arylketones with aminoacetalde- hyde acetals, it is used to synthesize isoquinolines. 1894 Knoevenagel condensation E. Knoevenagel Reactions involving carbonyl compounds Often used to generate α,β-unsaturated ketones through nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a dehydration reaction in which a molecule of water is eliminated. 1897 Gattermann and Gattermann-Koch formylation L. Gattermann and J.A. Koch Electrophilic aromatic substitution reactions Creation of a formyl (aldehyde) functionality by treating with a mixture of hydrogen cyanide (HCN) and hydrogen chloride (HCl) in the presence of a Lewis acid catalyst such as AlCl 3 . 1899 Baeyer-Villiger oxidation A. Baeyer and V. Villiger Nucleophilic substitution reactions Generation of an ester from a ketone or a lactone from a cyclic ketone using peroxyacids or peroxides. 1886 1900 Fries rearrangement K. Fries and colleagues Electrophilic aromatic substitution reactions Preperation of hydroxy aryl ketones through transformation of phenolic esters via Lewis acid catalysis. 1900 Grignard reaction V. Grignard Reactions involving carbonyl compounds Some important applications are the synthesis of alcohols, aldehydes or ketones, monocarboxylic acids, and other organometallic or organometalloid compounds via organo magnesium intermediates. 1901 Ullmann reaction F. Ullmann Transition metal-catalyzed couplings Traditionally the Ullmann reaction refers to the synthesis of symmetric biaryls via copper-catalyzed coupling at high temperatures (200 °C). 1906 Tishchenko reaction V. E. Tishchenko Nucleophilic substitution reactions Catalysed by aluminium alkoxides or sodium alkoxides generates the ester from the corresponding aldehyde. 1909 Prilezhaev reaction N.A. Prilezhaev Electrophilic addition reactions Reaction of an alkene with a peroxy acid (often meta-chloroperoxyben- zoic acid (m-CPBA), due to its stability and good solubility in most organic solvents) to form epoxides. 1911 Pictet-Spengler tetrahydroisoquinoline synthesis A. Pictet and T. Spengler Heterocycle formation An important acid-catalyzed transformation for the synthesis of tetrahydroisoquinolines from carbonyl compounds and β-arylethylamines. 1911 Wolff–Kishner reduction N. Kishner and L. Wolff Reduction reactions Converts carbonyl functionalities into alkanes. It is often used to remove a carbonyl group after it has served its synthetic purpose of activating an intermediate in a preceding step. 1913 Clemmensen reduction E.C. Clemmensen Reduction reactions Reduces aldehydes or ketones to alkanes in the presence of zinc amalgam and concentrated hydrochloric acid. 1915 Houben-Hoesch synthesis K.Hoesch and J. Houben Electrophilic aromatic substitution reactions This reaction is a type of Friedel-Crafts acylation with hydrogen chloride and a Lewis acid catalyst to prepare an aryl ketone from reaction of a nitrile with an arene compound. 1917 Mannich reaction C. Mannich Reactions involving carbonyl compounds Formation of a β-amino-carbonyl compound, also known as a Mannich base, through amino alkylation of an acidic proton next to a carbonyl containing functional group by formaldehyde and a primary or secondary amine or ammonia. 1919 Wohl-Ziegler bromination A. Wohl and K. Ziegler Free radical reactions Generates allylic and benzylic bromides through allylic or benzylic bromination of hydrocarbons using the reagent N-bromosuccinimide combined with a radical initiator. 1919 Staudinger reaction H. Staudinger and J. Meyer Reduction reactions Creates primary amines via the reaction between an azide and phosphine, which form a reactive aza-ylide as an intermediate that is hydrolyzed spontaneously. 1926 Meerwein–Ponndorf –Verley reduction H. Meerwein, W. Ponndorf and A. Verley Reduction reactions Hydrogenation which does not require the use of hazardous pressurized H 2 but utilizes available, inexpensive, and easy-to-handle hydrogen donor molecules to carry out the substrate hydrogenation. 1937 Oppenauer oxidation R.V. Oppenauer Oxidation Selective oxidation of secondary alcohols to ketones reaction takes place in the presence of [Al(i-PrO) 3 ] in an excess of acetone. 1937 Overman rearrangement L. Overman Pericyclic and photochemical reactions Generating allylic trichloroacetamides through an imidate intermediate from allylic alcohols it has found application in asymmetric synthesis. 1939 Hunsdiecker reaction C. and H. Hunsdiecker Free radical reactions Forms alkyl bromides via the decarboxylation of mercury or silver salts of carboxylic acids by treating with bromine. The alkyl bromide contains one fewer carbons than the carboxylic acid. 1939 Meerwein arylation H. Meerwein Free radical reactions A powerful tool for the diverse functionalization of alkenes through addition of an aryl diazonium salt (ArN 2 X) to an electron-poor alkene usually supported by a metal salt. 1941 Nazarov cyclization N. Nazarov Pericyclic and photochemical reactions Used in the synthesis of cyclopentenones from divinyl ketones, it is a powerful tool to create 5-membered rings. 1946 Jones oxidation E.R.H. Jones and colleagues Oxidation Used to convert primary alcohols into carboxylic acids or secondary alcohols into ketones using chromic acid (Jones Reagent). 1950 Wittig reaction G. Wittig and G. Geissler Reactions involving carbonyl compounds Preparation of alkenes through reaction of an aldehyde or ketone with a triphenyl phosphonium ylide (often called a Wittig reagent). 1954 Paterno-Büchi reaction E.P. di Sessa and G.H. Büchi Pericyclic and photochemical reactions Formation of oxetanes through the photochemical [2+2] cycloaddition of a carbonyl with an alkene. 1958 Simmons–Smith cyclopropanation H.E. Simmons Jr. and R.D. Smith Electrophilic addition reactions Creation of a cyclopropane ring via an organozinc carbenoid that reacts with an alkene (or alkyne). 1964 Eschenmoser - Claisen rearrangement A. Eschenmoser Pericyclic and photochemical reactions Produces a γ,δ-unsaturated amide when an allylic alcohol is heated with N,N-dimethylacetamide dimethyl acetal. 1967 Mitsunobu reaction O. Mitsunobu Nucleophilic substitution reactions Converts an alcohol into a variety of functional groups, such as an ester, using triphenylphosphine and an azodicarboxylate such as diethyl azodicarboxylate (DEAD) or diisopropyl azodicarboxylate (DIAD). 1968 Mislow-Evans rearrangement K. Mislow and D. Evans Pericyclic and photochemical reactions A general application for the preparation of trans-allylic alcohols from allylic sulfoxides in a 2,3-sigmatropic rearrangement. 1970 Heck reaction T. Mizoroki and R.F. Heck Transition metal-catalyzed couplings Used frequently in the synthesis of heterocyclic compounds the reaction of aryl halides or vinyl halides with activated alkenes in the presence of a Palladium-catalyst along with a base for C-C bond formation. 1974 Rubottom oxidation G.M. Rubottom, A.G. Brook and A. Hassner Oxidation Used for the synthesis of α-hydroxy ketones through reaction of silyl enol ethers with mCPBA, and subsequent rearrangement. 1974 Schwartz hydrozirconation D.W. Hart and J. Schwartz Electrophilic addition reactions Describes the use of the reagent Zirconocene hydrochloride otherwise known as zirconocene chloride hydride, a metallocene used for various transformations of alkenes and alkynes. 1976 Negishi cross-coupling reaction E. Negishi Transition metal-catalyzed couplings The Negishi reaction is the coupling of organo zinc compounds catalysed by Pd or Ni catalyst. Typically ArZnX + RX ---> Ar-R + ZnX 2 1978 Swern oxidation D.Swern and co-workers Nucleophilic substitution reactions A mild oxidation that converts a primary or secondary alcohol to the corresponding aldehyde or ketone using oxalyl chloride, dimethyl sulfoxide (DMSO) and an organic base, such as triethylamine. 1978 Stille cross-coupling reaction J.K. Stille Transition metal-catalyzed couplings Palladium catalyzed carbon-carbon bond formation via the coupling of an organotin compound with a variety of organic electrophiles. 1979 Suzuki cross-coupling reaction A. Suzuki Transition metal-catalyzed couplings Palladium catalyzed carbon-carbon bond formation where the coupling partners are a boronic acid/ester or equivalent and an organohalide. 1978 Luche reduction J.L. Luche Reduction reactions The selective organic reduction of α, β-unsaturated ketones to allylic alcohols with sodium borohydride (NaBH 4 ) and lanthanide chlorides, such as cerium (III) chloride (CeCl 3 ), in methanol or ethanol. 1980 Sharpless asymmetric epoxidation K.B. Sharpless and T. Katsuki Oxidation Used to prepare 2,3-epoxyalcohols from primary and secondary allylic alcohols. The reaction is catalyzed via a mixture of titanium tetra(isopropoxide) and diethyl tartrate. Dess–Martin oxidation D.B. Dess and A. Martin Oxidation Oxidation of primary alcohols to aldehydes and secondary alcohols to ketones via use of the Dess–Martin periodinane (DMP) reagent. 1983 1980 Noyori asymmetric hydrogenation R. Noyori Electrophilic addition reactions The asymmetric hydrogenation of aldehydes, ketones and imines catalyzed by Ru(II)-BINAP and related ruthenium complexes. 1996 Shi asymmetric epoxidation Y. Shi Electrophilic addition reactions Synthesis of epoxides from various alkenes using a fructose-derived organocatalyst with Oxone as the primary oxidant. 1884 Sandmeyer reaction T. Sandmeyer Free radical reactions Generates an aryl halide from the corresponding aryl diazonium salt using copper salts as catalysts or reagents. 1882 Hantzsch dihydropyridine synthesis A. Hantzsch Heterocycle formation Produces 1,4-dihydropyridines (DHPs), or “Hantzsch esters”, as isolable intermediates that can then be oxidized to pyridines. 1883 1877 Friedel-Crafts acylation and alkylation reaction C. Friedel and J.M. Crafts Electrophilic aromatic substitution reactions Acylation or alkylation of an aromatic ring via reaction with an acyl or alkyl halide in the presence of a strong Lewis acid typically aluminium chloride. Fischer indole synthesis E. Fischer and F. Jourdan Heterocycle formation Generates aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidic conditions. 1973 Keck radical allylation M. Kosugi and J. Grignon Free radical reactions Used for the conversion of aldehydes into homoallylic alcohols. 1953 Nobel Prize Winner 2010 Nobel Prize Winner 2001 Nobel Prize Winner 1902 Nobel Prize Winner 1905 Nobel Prize Winner 1912 Nobel Prize Winner 1963 Nobel Prize Winner 1979 Nobel Prize Winner 2010 Nobel Prize Winner 2010 Nobel Prize Winner 2001 Nobel Prize Winner : N : N : N+ - PPh 3 : Ph N N : : N : - Ph PPh 3 : N : N- Ph : N : PPh 3 : N Ph PPh 3 : : H-OH : N Ph PPh 3 : : OH H : - + : N Ph PPh 3 : O H : H : N Ph H H Pd(PPh 3 ) 4 THF + CH 2 = CHSn(Ch 2 CH 2 CH 2 CH 3 ) 3 Br a stannane + (CH 3 CH 2 CH 2 CH 2 ) 3 SnBR CH = CH 2 H Ph Me Me H Me Ph Me O H Ph : : : : : : O : : Me Me Ph 3 P + Ph 3 P + - Me Me Ph 3 P + H N(i-Pr) - 2 H Me Ph Me : O : Ph 3 P - - R’ R N R’ H COOR” R”OOC R’ OR” O O + 2 + NH 3 R – CHO R Me - MeO : : : O : : H R Me PhS : : O : : (MeO) 3 P: R Me S : : O : Ph R Me OH : : + NH 2 HN O R” R’ HN N R” R’ (H + ) (H + ) + H 2 N R” R’ N H -H + HN R” R’ - NH 3 HN R” R’ H 2 N (H + ) NH 2 R” R’ HN R-X Mg R Mg X R Mg X R 1 R 1 R 1 R 1 R MgX MgX R R O : O 2 R 1 R 1 OH OH H H 2 O + + + . δ δ + NH 2 1. NaNO 2 /HX 2. CuX X R – X + R’ Pd O base -HX R’ R Zn O Ph : : Me : Ph Zn . Me O : : . O : : Zn Ph Me HH Ph Me H ZnCI Ph Me H CI : : : Zn Ph Me H CI : : : Zn, HCI Learn more eu.fishersci.com/go/popular-organic-reactions Key named reactions in organic chemistry 1870 2000

Transcript of Key named reactions in organic chemistry...1870 Key named reactions in organic chemistry 2000 by...

Page 1: Key named reactions in organic chemistry...1870 Key named reactions in organic chemistry 2000 by Thermo Fisher Scienti˜c 2020 A l l o y s C a r b o n E t c h a n t s M e t a G a u

Knorr pyrrole synthesisL. Knorr Heterocycle formation Used to create substituted pyrroles through reacting an α-amino-ketoneand a compound containing an electron-withdrawing groupe.g. an ester to a carbonyl group.

1887Gabriel synthesisS. Gabriel Nucleophilic substitutionreactions Traditionally usingpotassium phthalimide transforms primary alkyl halides into primary amines.

1887Reformatsky reactionS. Reformatsky Reactions involving carbonylcompounds Condenses aldehydes or ketones with α-halo esters using metallic zinc to form β-hydroxy-esters.

1893Pomeranz-Fritsch reactionC. Pomeranz andP. Fritsch Heterocycle formationCondensation of benzaldehydes or arylketones with aminoacetalde-hyde acetals, it is used tosynthesize isoquinolines.

1894KnoevenagelcondensationE. Knoevenagel Reactions involvingcarbonyl compounds Often used to generateα,β-unsaturated ketones through nucleophilic addition of an active hydrogencompound to a carbonyl group followed by adehydration reaction in which a molecule of water iseliminated.

1897Gattermann andGattermann-Koch formylation L. Gattermannand J.A. Koch Electrophilic aromatic substitution reactions Creation of a formyl(aldehyde) functionality by treating with a mixture of hydrogen cyanide (HCN) and hydrogen chloride (HCl)in the presence of a Lewis acid catalyst such as AlCl3.

1899Baeyer-Villiger

oxidation A. Baeyer

and V. VilligerNucleophilic substitution

reactions Generation of an ester from

a ketone or a lactone from a cyclic ketone using

peroxyacids or peroxides.

1886

1900Fries rearrangementK. Fries and colleagues Electrophilic aromaticsubstitution reactionsPreperation of hydroxy aryl ketones through transformation of phenolic esters via Lewis acid catalysis.

1900Grignard reactionV. Grignard Reactions involving carbonyl compounds Some important applicationsare the synthesis of alcohols,aldehydes or ketones,monocarboxylic acids, andother organometallic ororganometalloid compoundsvia organo magnesiumintermediates.

1901Ullmann reactionF. Ullmann Transition metal-catalyzed couplings Traditionally the Ullmann reaction refers to the synthesis of symmetric biaryls viacopper-catalyzed coupling at high temperatures(200 °C).

1906TishchenkoreactionV. E. Tishchenko Nucleophilic substitution reactions Catalysed by aluminium alkoxides or sodiumalkoxides generatesthe ester from thecorresponding aldehyde.

1909Prilezhaev reactionN.A. Prilezhaev Electrophilic addition reactions Reaction of an alkene with a peroxy acid (often meta-chloroperoxyben-zoic acid (m-CPBA), due to its stability and good solubility in most organic solvents) to form epoxides.

1911Pictet-SpenglertetrahydroisoquinolinesynthesisA. Pictet and T. Spengler Heterocycle formation An important acid-catalyzed transformation for the synthesis of tetrahydroisoquinolines from carbonyl compounds andβ-arylethylamines.

1911Wolff–KishnerreductionN. Kishnerand L. Wolff Reduction reactions Converts carbonyl functionalities into alkanes. It is often used to remove a carbonyl group after it has served its synthetic purpose of activating anintermediate in a preceding step.

1913Clemmensen reductionE.C. Clemmensen Reduction reactions Reduces aldehydes or ketones to alkanes in the presence of zinc amalgam and concentratedhydrochloric acid.

1915Houben-HoeschsynthesisK.Hoesch and J. Houben Electrophilic aromatic substitution reactions This reaction is a type of Friedel-Crafts acylation withhydrogen chloride and a Lewis acid catalyst to prepare an aryl ketone from reaction of a nitrile with an arene compound.

1917Mannich reactionC. Mannich Reactions involving carbonyl compounds Formation of a β-amino-carbonyl compound, also known as aMannich base, through amino alkylation of an acidic proton nextto a carbonyl containing functional group by formaldehyde and a primary or secondary amine or ammonia.

1919Wohl-Ziegler brominationA. Wohl andK. Ziegler Free radical reactionsGenerates allylic and benzylic bromides through allylic or benzylic bromination of hydrocarbons using the reagentN-bromosuccinimide combined witha radical initiator.

1919Staudinger reactionH. Staudinger and J. Meyer Reduction reactions Creates primary amines via the reaction between an azide and phosphine, which form a reactive aza-ylide as an intermediate that is hydrolyzed spontaneously.

1926Meerwein–Ponndorf–Verley reductionH. Meerwein,W. Ponndorf andA. Verley Reduction reactions Hydrogenation which does not require the use of hazardouspressurized H2 but utilizesavailable, inexpensive, and easy-to-handle hydrogen donor molecules to carry out thesubstrate hydrogenation.

1937Oppenauer

oxidationR.V. Oppenauer

OxidationSelective oxidation of

secondary alcohols to ketones reaction takes place

in the presence of [Al(i-PrO)3] in an excess of

acetone.

1937Overman rearrangementL. Overman Pericyclic and photochemical reactions Generating allylic trichloroacetamides through an imidate intermediate from allylic alcohols it has found application inasymmetric synthesis.

1939Hunsdiecker reactionC. and H. Hunsdiecker Free radical reactionsForms alkyl bromides via the decarboxylation of mercury or silver salts of carboxylic acids by treating with bromine. The alkyl bromide contains one fewer carbons than the carboxylic acid. 

1939MeerweinarylationH. Meerwein Free radical reactionsA powerful tool for the diverse functionalization of alkenes through addition of an aryl diazonium salt (ArN2X) to an electron-poor alkene usually supported by a metal salt.

1941Nazarov cyclizationN. Nazarov Pericyclic andphotochemical reactions Used in the synthesis ofcyclopentenones from divinyl ketones, it is a powerful tool to create 5-membered rings. 

1946Jones oxidationE.R.H. Jones and colleagues OxidationUsed to convert primary alcohols into carboxylic acids or secondary alcohols into ketones using chromic acid (Jones Reagent).

1950Wittig reactionG. Wittigand G. Geissler Reactions involving carbonyl compounds Preparation of alkenes through reaction of an aldehyde or ketone with a triphenyl phosphoniumylide (often called a Wittig reagent).

1954Paterno-Büchi reaction

E.P. di Sessa and G.H. Büchi Pericyclic and photochemical reactions

Formation of oxetanes through thephotochemical [2+2] cycloaddition of a

carbonyl with an alkene.

1958Simmons–Smith

cyclopropanationH.E. Simmons Jr.

and R.D. SmithElectrophilic addition

reactions Creation of a cyclopropane

ring via an organozinc carbenoid that reacts with

an alkene (or alkyne).

1964Eschenmoser - ClaisenrearrangementA. Eschenmoser Pericyclic and photochemical reactionsProduces a γ,δ-unsaturated amide when an allylic alcohol is heated with N,N-dimethylacetamide dimethyl acetal.

1967Mitsunobu reaction

O. MitsunobuNucleophilic substitution

reactions Converts an alcohol into a

variety of functional groups, such as an ester, using

triphenylphosphine and an azodicarboxylate such as

diethyl azodicarboxylate (DEAD) or diisopropyl

azodicarboxylate (DIAD).

1968Mislow-Evans rearrangementK. Mislow and D. Evans Pericyclic and photochemical reactionsA general application for the preparation of trans-allylic alcohols from allylic sulfoxides in a 2,3-sigmatropic rearrangement.

1970Heck reactionT. Mizoroki and

R.F. Heck Transition metal-catalyzed

couplings Used frequently in the synthesis of

heterocyclic compounds the reaction of aryl halides or vinyl halides with

activated alkenes in the presence of a Palladium-catalyst along with a

base for C-C bond formation.

1974Rubottom oxidationG.M. Rubottom, A.G. Brookand A. Hassner OxidationUsed for the synthesis of α-hydroxy ketones through reaction of silyl enol ethers with mCPBA, and subsequent rearrangement.

1974SchwartzhydrozirconationD.W. Hart andJ. Schwartz Electrophilic addition reactions Describes the use of the reagent Zirconocene hydrochlorideotherwise known as zirconocene chloride hydride, a metallocene used for various transformations of alkenes and alkynes.

1976Negishi cross-couplingreactionE. NegishiTransition metal-catalyzed couplings The Negishi reaction is the coupling of organozinc compounds catalysed by Pd or Ni catalyst.Typically ArZnX + RX ---> Ar-R + ZnX2

1978Swern oxidationD.Swern and co-workers Nucleophilic substitution reactions A mild oxidation that converts a primary or secondary alcohol to the corresponding aldehyde or ketone using oxalyl chloride, dimethyl sulfoxide (DMSO) and an organic base, such as triethylamine.

1978Stille cross-coupling reactionJ.K. Stille Transition metal-catalyzed couplings Palladium catalyzed carbon-carbon bond formation via the coupling of an organotin compound with a variety of organicelectrophiles.

1979Suzuki cross-coupling reactionA. Suzuki Transition metal-catalyzedcouplings Palladium catalyzed carbon-carbon bond formation where the coupling partners are a boronic acid/ester or equivalent and an organohalide.

1978Luche reductionJ.L. Luche Reduction reactions The selective organic reduction of α, β-unsaturated ketones to allylic alcohols with sodium borohydride (NaBH4) and lanthanide chlorides, such as cerium(III) chloride (CeCl3), in methanol or ethanol.

1980SharplessasymmetricepoxidationK.B. Sharplessand T. Katsuki OxidationUsed to prepare2,3-epoxyalcohols from primary and secondaryallylic alcohols. The reaction is catalyzed via a mixture of titanium tetra(isopropoxide) and diethyl tartrate.

Dess–MartinoxidationD.B. Dess andA. Martin OxidationOxidation of primary alcohols to aldehydes and secondary alcohols to ketones via use of the Dess–Martin periodinane (DMP) reagent.

1983

1980Noyori asymmetrichydrogenationR. Noyori Electrophilic addition reactions The asymmetric hydrogenation of aldehydes, ketones and imines catalyzed by Ru(II)-BINAP and related ruthenium complexes.

1996Shi asymmetricepoxidationY. Shi Electrophilic additionreactions Synthesis of epoxides from various alkenes using afructose-derived organocatalyst with Oxone as the primary oxidant.

1884Sandmeyer reaction

T. SandmeyerFree radical reactions Generates an

aryl halide from the corresponding aryl diazonium salt using copper salts as

catalysts or reagents.

1882Hantzsch

dihydropyridine synthesis

A. HantzschHeterocycle formation

Produces1,4-dihydropyridines

(DHPs), or “Hantzsch esters”, as isolable

intermediates that can then be oxidized to pyridines.

1883

1877Friedel-Crafts acylation and alkylation reactionC. Friedel and J.M. CraftsElectrophilic aromatic substitution reactions Acylation or alkylation of an aromatic ring via reaction with an acyl or alkyl halide in the presence of a strong Lewis acid typically aluminium chloride.

Fischer indole synthesisE. Fischerand F. JourdanHeterocycle formation Generates aromatic heterocycle indole from a (substituted) phenylhydrazine and an aldehyde or ketone under acidicconditions.

1973Keck radical allylationM. Kosugi and J. Grignon Free radical reactionsUsed for the conversion ofaldehydes into homoallylic alcohols.

1953NobelPrize Winner

2010NobelPrize Winner

2001NobelPrize Winner

1902NobelPrize Winner

1905NobelPrize Winner

1912NobelPrize Winner

1963NobelPrize Winner

1979NobelPrize Winner

2010NobelPrize Winner

2010NobelPrize Winner

2001NobelPrize Winner

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Learn more eu.fishersci.com/go/popular-organic-reactions

Key named reactions in organic chemistry1870 2000

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