Interferon α-2b

Reactions 1297 - 17 Apr 2010 Interferon α-2b Hypersensitivity in an elderly patient, managed with desensitisation: case report A 65-year-old man developed hypersensitivity during treatment with interferon α-2b [PDferon]; subsequent desensitisation was successful. The man had chronic hepatitis C (genotype 1b), with moderate activity and advanced fibrosis. He began treatment including interferon α-2b [dosage not stated]. Following the first administration of interferon α-2b, he developed a maculopapular rash, low-grade fever and severe itching [time to reaction onset not stated]. Interferon α-2b was subsequently stopped, and the man was diagnosed with hypersensitivity to interferon. However, since there were no other treatment options available, he underwent desensitisation. On the first day, interferon α-2b was administered subcutaneously every hour, starting at 3IU and increasing to 3000IU per dose, over 13 hours for a cumulative dose for the day of 24 666IU. The second day, interferon α-2b was again administered every hour, this time starting at 300IU and increasing to 300 000IU per dose, over 7 hours for a cumulative dose for the day of 1 266 000IU. From day 3 until the end of the first week, he received interferon α-2b 1 500 000 IU/day in the morning, and from the second week until the end of treatment (week 54), he received interferon α-2b 3 000 000IU every other day. The only observed reaction was a mild generalised pruritus, occurring at the start of day 2, which responded to IM diphenhydramine. At the end of treatment, repeated tests indicated the eradication of HCV. Taghavi SA, et al. Successful interferon desensitization in a patient with chronic hepatitis C infection. World Journal of Gastroenterology 15: 4196-4198, No. 33, 7 Sep 2009. Available from: URL: http://dx.doi.org/10.3748/wjg.15.4196 - Iran 803010743 1 Reactions 17 Apr 2010 No. 1297 0114-9954/10/1297-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved

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Transcript of Interferon α-2b

Reactions 1297 - 17 Apr 2010

Interferon α-2b

Hypersensitivity in an elderly patient, managedwith desensitisation: case report

A 65-year-old man developed hypersensitivity duringtreatment with interferon α-2b [PDferon]; subsequentdesensitisation was successful.

The man had chronic hepatitis C (genotype 1b), withmoderate activity and advanced fibrosis. He begantreatment including interferon α-2b [dosage not stated].Following the first administration of interferon α-2b, hedeveloped a maculopapular rash, low-grade fever andsevere itching [time to reaction onset not stated].

Interferon α-2b was subsequently stopped, and the manwas diagnosed with hypersensitivity to interferon.However, since there were no other treatment optionsavailable, he underwent desensitisation. On the first day,interferon α-2b was administered subcutaneously everyhour, starting at 3IU and increasing to 3000IU per dose,over 13 hours for a cumulative dose for the day of24 666IU. The second day, interferon α-2b was againadministered every hour, this time starting at 300IU andincreasing to 300 000IU per dose, over 7 hours for acumulative dose for the day of 1 266 000IU. From day 3until the end of the first week, he received interferon α-2b1 500 000 IU/day in the morning, and from the secondweek until the end of treatment (week 54), he receivedinterferon α-2b 3 000 000IU every other day. The onlyobserved reaction was a mild generalised pruritus,occurring at the start of day 2, which responded toIM diphenhydramine. At the end of treatment, repeatedtests indicated the eradication of HCV.Taghavi SA, et al. Successful interferon desensitization in a patient with chronichepatitis C infection. World Journal of Gastroenterology 15: 4196-4198, No. 33, 7Sep 2009. Available from: URL: http://dx.doi.org/10.3748/wjg.15.4196 -Iran 803010743