Index

β-Hydroxy acyl-CoA dehydrogenase (β-HAD),117

Álvarez-Sánchez, B., 216, 21713C labelling, 242, 245, 2472-Hydroxyisobutyric acid (α-HB), 2302D difference gel electrophoresis (DIGE), 1975-(Tetradecyloxy)-2-furoic acid (TOFA), 141

AAarsland, A., 33Abderrahmani, A., 93Aboka, F.O., 245Abrams, G.A., 44Abumrad, N., 117Abuoun, M., 282Accurate mass tag (AMT), 189Acetyl-CoA carboxylase (ACC), 32, 141Achten, J., 116Ackermann, A.M., 92Adachi, J., 197Adamian, L., 309Adams, J.M., 118Adaptive mechanism, 5, 228Adiels, M., 35, 161–163, 165–167Adipocentric model, 6, 8, 9Adipocyte, 7, 9–13, 32, 33, 38, 41, 64–66,

68–73, 75, 124, 177, 178, 197, 198, 202,224, 226, 228, 308

Adipokines, 12, 42, 43, 65, 66, 198Adiponectin, 7, 9, 12, 41–43, 65, 66, 68, 69,

71–75, 139, 166, 198Adipose tissue, 7–12, 29, 32, 33, 36–38, 40–43,

64–66, 69–75, 95, 113, 117, 124, 125,144, 147, 158, 172, 174, 178, 196–198,202, 203, 224, 225, 227, 228, 230, 257,259, 306, 343, 344, 357, 358, 362

as an endocrine organ, 197as biomarker, 252

as energy storage organ, 12fat deposition in, 14fatty acids (FAs) in, 342, 343lipolysis in, 226protein recovery, 197

Adipose tissue expandability, 64Adipose tissue expandability hypothesis, 10Adipose tissue inflammation, 12, 14Adlercreutz, H., 259Aebersold, R., 188Aggio, R.B., 222Agoram, B., 356Aguer, C., 118Aguirre, V., 114Ahima, R.S., 66Ahmed, M., 202Ahrens, C.H., 187, 188Ai, Z.L., 37Aittoniemi, J., 304Akesson, M., 286, 294Alaiya, A., 188Alberti, K.G., 3, 4, 86, 93Albu, J.B., 342Alexander, C.A., 166Alkhalaf, A., 201Allet, N., 192Allison, C., 255Allostasis, 5Allostatic adaptations, 4in homeostasis maintenances, 5

Allostatic load, 6Altomonte, J., 32Alwine, J.C., 149Amacher, D.E., 188Amaral, A.I., 245AMP-activated protein kinase (AMPK), 35,

142–144, 173Analysis of Variance (ANOVA), 325, 330–335

M. Orešic, A. Vidal-Puig (eds.), A Systems Biology Approach to Study Metabolic Syndrome, 367DOI 10.1007/978-3-319-01008-3, © Springer International Publishing Switzerland 2014

368 Index

Anandamide (AEA), 177, 178Andersen, T., 46Anderson, E.J., 125Andersson, U., 143, 144Andreasen, M.F., 266, 267Andrews, Z.B., 140, 150Andrikopoulos, S., 99Anello, M., 94Angelico, F., 166Angelin, B., 39Angiogenesis, 12, 66Angulo, P., 44Anthocyanins, 260, 267–269Antoniewicz, M.R., 243, 244Apolipoproteins, 38, 158, 162Appeldoorn, M.M., 265Arabidopsis thaliana, 283, 291Arachidonic acid, 11, 227, 228, 306, 308Aranibar, N., 220Arcuate nucleus (ARC), 138Arita, Y., 69, 71Ariyama, Y., 147Armoni, M., 343Arner, P., 10, 113Arvidsson, E., 203Asensio-López, M.C., 69, 74Aston-Mourney, K., 99Athyros, V.G., 41Aura, A.-M., 253, 255, 256, 258–261, 265, 268Austin, R.C., 145Autophagy, 13, 86, 96, 97Avram, M.M., 65Avruch, J., 230Ayton, G.S., 300, 301

BBäckhed, F., 172–174Bò, C.D., 269Babushok, V.I., 220Bach Knudsen, K.E., 259Bach, D., 121, 122Backhed, F., 173Bacon, B.R., 43Bahceci, M., 64Bai, N., 253Bajaj, M., 343Balkau, B., 28Bandyopadhyay, G.K., 114Banerjee, R.R., 70Banks, R.E., 196Bar-Joseph, Z., 333, 337Barbier, O., 37Bard scoring system, 45

Barrett, P.H., 164Barroso, I., 122Barry, J.L., 255, 256Barter, P.J., 226Basseri, S., 145Bateman, R.H., 193Bates, S.H., 66Bateson, M.C., 39Baxter, C.J., 244Baynes, J.W., 291Bazzocco, S., 256, 265Bearne, C.A., 255Beavis, R.C., 187, 189Becker, S.A., 294Befroy De, P.K., 119, 121Beil, U., 39Bell, G.D., 39Bell, K.S., 114Benani, A., 140Bendall, S.C., 194, 195Benjamini, Y., 320, 326Benzoic acid, 261, 265, 267, 269Berg, A.H., 69Berg, J.M., 282Bernal-Mizrachi, C., 40Bernroider, E., 30Beta-cell, 86, 88–100Beynon, R.J., 190Billin, A.N., 42Bilu, Y., 286Bilz, S., 39Bing, C., 227Bioinformatics, 204, 314Birnbaum, M.J., 114Birner-Gruenberger, R., 197Bischof, M.G., 30Bjork, E., 99Bjornholm, M., 113Bjursell, M., 177Blaak, E.E., 120Blood brain barrier (BBB), 140Bluher, M., 69Bock, K., 291Bodary, P.F., 68Boden, G., 30, 33, 71, 90, 118, 147Bogardus, C., 114Boirie, Y., 124Bonadonna R.C., 115Bonadonna, R.C., 112, 115Bondarenko, P.V., 192Bonen, A., 117, 118Boni-Schnetzler, M., 90, 95Bonner-Weir, S., 99

Index 369

Bookout, A.L., 37Boren, J., 161, 166, 240, 242Boschetti, E., 189Bothwell, J.H., 238Bouche, C., 89Boura-Halfon, S., 113Boushel, R., 118, 119, 122Bouskila, M., 116Bouwman, F.G., 203Bouzakri, K., 113Boyko, E.J., 68Boyle, J.G., 74Braithwaite, S.S., 114Brakenhielm, E., 12Brand-Miller, J., 71Bratchell, N., 334Braune, A., 267Breiman, L., 328Briaud, I., 91Broder, S., 187Brody, E.N., 194, 195Brown adipose tissue (BAT), 12, 144, 176Brown fat oxidization, 14Brown, M.S., 32Brown, N.F., 117Brown, R.J., 98Brown, W.V., 32Browning, J.D., 33, 35, 37, 44Bruce, C.R., 118Bruce, K.D., 63, 65Bruggeman, F.J., 239Brunham, L.R., 93Brunner, Y., 199Brunt scoring system, 45Brunt, E.M., 45Bruss, M.D., 114Bruun, J.M., 71, 72Bugianesi, E., 29, 30, 42, 166Burgess, S.C., 241Busch, A.K., 91Butler, A.E., 88, 96Byrne, C.D., 28, 63, 65

CCaballero, F., 34Cabrero, A., 41Caesar, R., 174, 227Cairns, R.A., 292Caldwell, S.H, 29, 166Cales, P., 45Calle, E.E., 138Calvo, S.E., 199Campbell, J., 117

Campbell, W.L., 255Campfield, L.A., 149Cani, P.D., 174, 177, 257Cannon, B., 144Cantor, R.S., 310, 311Cao, G., 38Cao, Y., 12Capeau, J., 28, 32, 34, 42Carbohydrate response element-binding protein

(ChREBP), 33–35, 172Cardio-metabolic syndrome, 64Cardiovascular disease (CVD), 157

risks of, 27, 157, 162Carey, P.E., 114Cargile, B.J., 189Cariou, B., 39Carling, D., 138, 141, 142Carlsson, C., 230Carnitine palmitoyltransferase (CPT) system,

117Caron, S., 32Carpentier, A., 90, 165Carpentier, A.C., 90Carulli, N., 39Carvalho, C., 336Cascante, M., 238–240Castillo, S., 220Castro-Perez, J.M., 237Catalase, 94Celeux, G., 332Cell surface-capturing (CSC) technology, 195Central nervous system (CNS), 138Ceramides, 10, 13, 15, 118, 227Cerda, B., 259, 260Cevallos-Cevallos, J.M., 270Cha, J.Y., 38Chakravarthy, M.V., 40Chan, D.C, 162, 163, 166, 167Chang, X., 36Charles, M.A., 28Chatziioannou, A., 282Chawla, A., 38Chelius, D., 192Chen, D.F., 37Chen, H., 121Chen, K., 162Chen, M., 32Chen, S., 114Chen, W., 63Chen, X., 90Chenodeoxycholic acid (CDCA), 38, 39Chernomordik, L.V., 308Chibalin, A.V., 113

370 Index

Chinetti, G., 40, 41Chisari, V., 291Choi, J., 243Choi, J.H., 70, 73Choi, S.E., 97Cholesterol ester transport protein (CETP), 35,

40, 158, 161Cholic acid (CA), 38Choudhury, A.I., 89Christesen, H.B., 99Chromatography, 190, 217, 220Chun, T.H., 13Chylomicrons, 32, 35, 158, 174, 357Claret, M., 145Clark, J.M., 166Claudel, T., 39Claus, S.P., 175, 176Clayton, J.J., 175Clayton, T.A., 175Clifford, M.N., 268Cline, G.W., 115Clustering, 325, 326, 332, 333Cnop, M., 90, 98, 147CNS-related symptoms, 149Coarse-grained modelling, 301–303, 305, 315Cohen, J.C., 224Cohn, J.S., 32Colas, R., 93Colberg, S.R., 120Colinge, J., 187, 189Collins, H., 198Collins, J.M., 241Colonic metabolism, 252, 253Combs, T.P., 69, 72Computed tomography (CT), 44, 45Computer simulation, 300, 303Conrads, T.P., 189Consoli, A., 121Constraint-based modeling (CBM), 222,

282–285, 289, 291, 294Contreras, F.X., 303, 309Coronary heart disease (CHD), 162, 224Corpeleijn, E., 120Corton, M., 197Costanzo-Garvey, D.L., 144Costello, E.K., 171Cota, D., 138, 148Crabb, D.W., 34, 36Craig, R., 187, 189Crawford, P.A., 172Crouse, J.R., 39Cunha, D.A., 147Curien, G., 239

Curto, R., 239Cusi, K., 121Cyranoski, D., 196Czech, A., 342

Dda Silva Xavier, G., 91Dagenais, G.R., 116Damian, D., 324, 326Damsbo, P., 114, 116Danforth, E., Jr., 65Daran-Lapujade, P., 286Dashti, N., 35Data integration, 320, 336–338Davis, D.B., 93Day, A.J., 258Day, C., 43Day, C.P., 42, 43, 46De Atauri, P., 239De Ferranti, S., 64, 65De Feyter, H.M., 119De Graaf, A.A., 164De Mello, V.D.E., 252, 253De novo lipogenesis (DNL), 33, 39, 43, 138,

141, 164, 172Defronzo, R.A., 111, 112Del Guerra, S., 94Del Prato, S., 116Delepine, M., 98Delghingaro-Augusto, V., 99Denechaud, P.D., 34Deng, S., 94Deng, W.J., 199Deng, Y., 65, 66, 69, 198Dent, P., 115, 116Depréz, S., 255, 265Deshpande, R., 244Despres, J.P., 65Dettmer, K., 217, 220Di Marzo, V., 177Di Nardo, A., 149Diabetes, 3, 44, 65, 68, 69, 86, 89, 97, 98,

100, 121, 123, 147, 178, 196, 199, 200,226, 228

animal model, 98, 200biomarkers of, 200onset of, 95risk of, 27, 93, 224

Diacylglycerol (DAG), 10, 13, 15, 118, 125,227

Diehl, A.M., 166Dietary fibre (DF), 252, 253, 255, 256Ding, S., 173Dixon, J.B., 46

Index 371

DNA aptamers, 195Doege, H., 33Dohm, G.L., 112, 115Doliba, N.M., 94Dominguez-Bello, M.G., 171Dominiczak, M.H., 291Domon, B., 187Donath, M.Y., 95Donnelly, K.L., 32, 43Donovan, J.L., 259Dor, Y., 88Dorsomedial nucleus (DMH), 139, 141Dowell, P., 141, 142Dowman, J.K., 43Draznin, B., 113Drew, B.G., 93Dry fractionation, 267Duarte, N.C., 222, 282, 286, 290Dube, M.G., 252Dudley, E., 237Duffaut, C., 71Duggan G.E., 225Durot, M., 282Duval, C., 38Duvillard, L., 167Dyck, D.J., 118Dyslipidaemia, 3, 10, 157, 162Dzamko, N., 145

EEbato, C., 97Eckel, R.H., 3, 4, 251Edvardsson, U., 202Edwards, C.A., 255Edwards, J.S., 282, 285Edwards, P.A., 38Efron, B., 329Eguez, L., 114Ehses, J.A., 95Eizirik, D.L., 98, 145–147Ek, J., 122El Assaad, W., 147El Ouaamari, A., 88El-Assaad, W., 90Electrospray ionisation (ESI), 186Elias, J.E., 190Ellingsgaard, H., 95Elmquist, J.K., 66, 138, 139Elouil, H., 147EMC remodelling, 13Endo, H., 149Endoplasmic reticulum stress (ER stress), 6,

13, 36, 71, 86, 98, 99, 140, 145–148,150, 201

in hypothalamus, 150obesity-induced, 148oxidative-induced, 149

Eng, J.K., 189Engelmann, B., 228Epididymal adipose tissue (EWAT), 227ER dysfunction, 147ER-to-Golgi protein traffikopus01kkcking, 98Eriksson, J., 112, 115Escribano, O., 88Esposito, K., 75Evans, J.L., 230Evans, K., 357Everard, A., 257Everett-Grueter, C., 343Everhart, J.E., 44

FFabbrini, E., 35, 166Fahy, E., 226Fain, J.N., 68Faine, L.A., 73Falck-Ytter, Y., 43Famili, I., 285, 286Fan, T.W., 245Fan, X., 145Farooqi, I.S., 138Farsenoid X receptor

bile acid (BA) conjugation, 38FXR-α, 38, 39FXR-β, 38

Fatty acid binding proteins (FABPs), 33Fatty acid oxidation (FAO), 30, 66, 116–120,

141, 144, 173, 227in mitochondrial matrix, 36

Fatty acid transport protein (FATP), 33Fatty acids (FAs), 29, 65, 71, 72, 90, 91, 95–98,

117–119, 124, 125, 140, 141, 158, 161,203, 213, 219, 226, 227, 230, 252,309, 342

impaired β-oxidation of, 29Fausto, N., 291Fawcett, K.A., 122Federici, M., 94Feist, A.M., 240, 282Felber, J.P., 342Felgines, C., 259Felig, P., 225, 226, 228Fernandez-Alvarez, J., 94Fernandez-Miranda, C., 41Ferrannini, E., 114Ferre, P., 30, 34Ferulic acid dimers, 267Fex, M., 94

372 Index

Fiehn, O., 226, 231Fisher, R., 331Flavanols, 260, 261Flavonoid glycosides, 258Fleissner, C.K., 173Fleschhut, J., 268Flier, J.S., 138Fluxome, 238Fluxomics, 238, 240, 246, 247Folger, O., 292Fong, S.S., 285, 286Fontes, G., 90–92, 99, 199Ford, E.S., 64Foretz, M., 34Forman, B.M., 40Forrester, S.C., 269Foster, L.J., 191Foufelle, F., 30, 34Free fatty acids (FFAs), 32, 36, 43, 147, 226Frenkel, D., 301, 303Frezza, C., 292Fridlyand, L.E., 230Friedman, J.M., 66, 138Fruhbeck, G., 138Fu, S., 201Fuller, N., 308Funahashi, T., 70

GGaglio, D., 241Galgani, J.E., 120Galisteo, M., 74, 252Gall, W.E., 231Gangabadage, C.S., 167Gao, Q., 138, 139Gao, Z., 114Garfinkel, D., 282Gartner, C.A., 191Gas chromatography (GC), 217, 219–221, 243Gastaldelli, A., 30, 35Gauthier, M.S., 33Gaziano, T.A., 157Geer, L.Y., 187Gelman, A., 331Genomics, 186, 200, 204Gerber, S.A., 190German, M.S., 96Geromanos, S.J., 193Ghouri, N., 44Ghrelin, 139Gil-Izquierdo, A., 253Giles, T.D., 72Gille, C., 294

Gillet, L.C., 193Ginsberg, H.N., 32Girard, J., 34Glaser, B., 99Glass, C.K., 12, 124Glitazones, 72Glucolipotoxicity, 86, 90, 91

concept of, 90Glucose metabolism, 30, 34, 37, 39, 41, 75, 87,

94, 112, 114, 119, 174, 176, 177, 225,226, 228, 252

gluconeogenesis, 30glycogen synthesis, 112, 115, 224glycogenolysis, 30

Glucosinolates, bioconversion of, 256GLUT4 trafficking, 114Glutathione peroxidases (GPx), 94Glycogen, 30, 32, 34, 111, 224, 244, 343Godsland, I.F., 68Golay, A., 342Golbidi, S., 94Gold, L., 194, 195Goldstein, J.L., 32Gonthier, M.-P., 265, 267Goodacre, R., 282Goodlett, D.R., 191Goodyear, L.J., 112, 113Gordon, J.I., 172Goto, S., 282Gottlicher, M., 40Grün, C.H., 260Grass, G., 356Grattagliano, I., 46, 252Greco, D., 33Green tea, epigallocatechin gallate, 253, 261Green, R., 226Green, R.M., 29, 32Greenberg, A.S., 72Greiner, T., 173Griffin, J.L., 238Grill, V., 99Grill, V.E., 99Gronwald, W., 216Groop, L.C., 112Gropper, S., 291Gross, M., 259Grundy, S.M., 63, 65Gu, L., 247Gudmundsson, S., 240Guettier, J.M., 32Gustafsson, J.A., 37Gut microbiota, 171–178, 213Gutierrez, A., 39

Index 373

Gutierrez-Juarez, R., 68Guyton, A.C., 259Gwiazda, K.S., 98Gygi, S., 186, 191Gygi, S.P., 190

HHaataja, L., 96Habener, J.F., 147Hagman, D.K., 91, 92Halaas, J.L., 66, 197Hall, A., 305Hall, J.E., 68Halliwell, B., 230Halvatsiotis, P., 124Hamaguchi, M., 29Hamilton, J.A., 117Han, X.X., 118Hanahan, D., 292Handschin, C., 123Hanhineva, K., 260Hanke, S., 199Hansen, B.T., 189Hara, K., 122Harano, Y., 41Harder, H., 266Haring, R., 44Harrison, S.A., 45Hashimoto, N., 89Hashimoto, T., 40Hattori, M., 257Havel, R.J., 162He, F., 291He, M., 342He, W., 141Hegarty, B.D., 118Heijtz, R.D., 174Hein, E.-M., 259Heinonen, S., 259Heinrich, R., 239Hemery, Y., 267Henquin, J.C., 88Henry, O., 243Hepatic steatosis, 8, 28, 29, 32–34, 40–42,

44, 177Hepatitis B virus, 149Herder, C., 86Hernandez-Alvarez, M.I., 121Hess, B., 282, 303Hickman, I.J., 46High-density lipoprotein (HDL), 8, 28Higuchi, N., 34, 36, 37Hiller, K., 243

Hirasawa, A., 343Hirokane, H., 39Hirosumi, J., 71, 114Hiukka, A., 167Hochberg, Y., 320, 326Hoehn, K.L., 125Hoene, M., 95Hojlund, K., 199Holland, W.L., 227Holloway, G.P., 118, 119Holman, R.R., 86Holmes, E., 213Homeostasis model of assessing insulin

resistance (HOMA-IR), 166Hoofnagle, A.N., 196Hoppa, M.B., 91Hoppel, C., 117Horai, H, 221Horikawa, Y., 35Hormone-sensitive lipase (HSL), control of, 33Horton, J., 30, 35Horton, J.D., 33, 35Horvath, T.L., 138, 139Hosoi, T., 147, 148, 150Hotamisligil, G.S., 71, 145Hotta, K., 69Houstis, N., 125, 230Hoy, A.J., 118Hsich, G., 188Hu, Q., 187, 188Hu, Z., 141, 142Huang, C.J., 147Hubbard, S.R., 145–147Hui, J.M., 42Human metabolic model, 282, 289, 290Human Proteome Organisation (HUPO), 196Human Proteome Project (HPP), 196Hummel J, 221Humpf, H.U., 268Hunte, C., 309Huopaniemi, I., 323, 335, 337Huopio, H., 99Hwang, H., 199Hyötyläinen, T., 217, 220, 231Hydroxycinnamic acids, 260, 266, 267Hyperglycemic-hyperinsulinemic clamp, 112,

114Hypertension, 9, 28, 63–65, 68, 69, 72, 114,

224, 226, 251Hypertriglyceridaemia, 8Hypothalamus, 4, 66, 138, 140, 141, 143,

147–150Hypoxia, 13, 214

374 Index

IIbarra, R.U., 285Ibarrola, N., 191Ide, T., 34Iizuka, K., 35Ikemoto, S., 176Imai, J., 88In vitro digestion models, 252, 255, 256, 258,

265–269, 292, 294Inada, A., 88Inflammation, 11–13, 37, 40–43, 45, 46, 63,

70–72, 75, 86, 90, 95, 124, 148, 174,197, 228, 251, 252, 257

Insulin, 5Insulin exocytosis, 88, 93

late stages of, 91Insulin resistance, 3–5, 8–10, 12–14, 28,

30, 63, 65, 69–73, 86, 88, 89, 92,93, 97–100, 112, 116–118, 120,121, 123–126, 138, 140, 166, 176,196, 199, 202, 224, 226–228, 230,251, 257

FA induced, 65in muscle, 125pathogenesis of, 114

Insulin resistance syndrome, 64Insulin sensitivity, 7, 12, 13, 29, 34, 39, 41, 46,

47, 66, 68–70, 72, 93, 113, 121–123, 174in muscle, 126

Insulin signaling, 30, 41, 69, 112, 113,122–124

Insulin-mediated glucose disposal (IMGD), 8Interferon gamma (IFNγ), 71Interleukins (ILs)

IL-1, 7IL-1β, 95, 124IL-10, 124IL-13, 124IL-6, 71, 124IL-8, 124

Iozzo, P., 227Ippel, J.H., 191Ishihama, Y., 192Islet, 86, 90–96, 98, 99, 147, 198, 199, 203Islet amyloid polypeptide (IAPP), 96Isoelectric focussing (IEF), 193Isomaa, B., 63Isotopic steady state, 243, 244Isotopologue, 221, 242–244Isotopomer, 242–245

mass isotopomer, 243positional isotopomer, 243

Itani, S.I., 114, 118

JJacobs, D.M., 260Jacobs, J.M., 198Jacqueminet, S., 91James, O., 43James, O.F., 42, 43, 46Jamshidi, N., 282Janowski, B.A., 37Janson, J., 96Jansson, A., 225Jensen, M.D., 65Jensen, M.O., 309Jensen, O.N., 187Jensen, P.A., 294Jerby, L., 222, 289, 290, 294Jheng, H.F., 122Jiang, G., 41Jin, H.O., 149Jonas, J.C., 99Joseph, S.B., 38Joshi, A., 282Jouhten, P., 245Joy, D., 44Jung, H.S., 70, 97Juntunen, K.S., 259

KKaaks, R., 138Kabashima, T., 35Kadowaki, T., 68Kahn, B.B., 138, 141, 142, 145, 173Kahn, S.E., 114Kaiser, H.J., 309Kalaany, N.Y., 37Kallwitz, E.R., 41Kalt, W., 259, 269Kamerlin, S.C.L., 301Kamin, D., 70Kanehisa, M., 282Kaneko, K., 89Kankainen, M., 222, 329Karaskov, E., 98Karlsson, H.K., 114, 115Kase, E.T., 38Kashyap, S., 90Kast, H.R., 39Kasuga, M., 89Katajamaa, M., 221Katz, A., 342Kau, A.L., 178Kauffman, K.J., 285Kaufman, R.J., 71, 98Kaushik, S., 97

Index 375

Kawaguchi, T., 35Keay, S., 71Keller, A., 187, 190Kelley, D.E., 114, 116, 118–122, 343Kelpe, C.L., 90, 91Keppler, K., 268Kern, S.M., 259Kerner, J., 117Kersten, S., 40, 41Khan, T., 13Kharroubi, I., 36Kiens, B., 117Kilkkinen, A., 259, 260Kim, D.-H., 259Kim, E.K., 141Kim, J.K., 114Kim, J.Y., 73, 118, 119, 343Kim, Y.B., 68, 113Kind, T., 220Kinetic modeling, 282Kirkpatrick, S., 245Kissebah, A.H., 226Kitamura, T., 124Klein, H.H., 113Kliewer, S.A., 40Knust, U., 259Kobashi, K., 259Kobayashi, H., 68Koivuniemi, A., 312Koli, R., 268Kondo, H., 68Koo, S.H., 40Kopka, J., 220Korchak, H.M., 33Korenblat, K.M., 29Koseki, M., 93Kotronen, A., 224, 227Koves, T.R., 119Kozlitina, J., 33Kozlov, M.M., 308Krömer, J., 238, 240Kraegen, E.W., 29Kraft, C.S., 123Kramer, D., 41Kratchmarova, I., 197Krebs cycle, 87, 94, 117, 121, 216, 226, 240,

242, 292Krijgsveld, J., 191Krook, A., 113, 114Kroon, P.A., 266Kruger, M., 197Kruit, J.K., 93Kruszynska, Y.T., 115

Kubota, N., 89Kuchel, P.W., 237, 247, 282Kuhajda, F.P., 141Kuijsten, A., 253, 259Kulkarni, R.N., 89Kullin, M., 99Kumar, V.S., 282Kumari, S., 221Kuster, B., 186, 190Kusunoki, J., 230Kyriakis, J.M., 230

LLópez, M., 138, 139, 141–145, 150Laaksonen, D.E., 226Lachin, J.M., 39Lackner, C., 45Lada, A.T., 161Lafay, S., 253, 258Laffitte, B.A., 38Lage, R., 138, 143, 145Lam, T.K., 140, 141, 149Lambert, G., 39Lamers, D., 198Lampe, J.W., 259, 260Lane, A.N., 238, 243Lane, M.D., 147Langsrud, O., 334Lanne, B., 197Lanpher, B., 222Lanz, R.B., 37Larsen, C.M., 95Larsen, T.M., 203Larter, C.Z., 29, 32Las, G., 97Lasonder, E., 192Lateral hypothalamic area (LHA), 139Laurin, J., 41Lavoie, J.M., 33Laybutt, D.R., 98, 99, 147Le Foll, C., 149Le, H.-S., 337Leahy, J.L., 99Lee, F.Y., 39Lee, I.-D., 282Lee, J.K., 222Lee, M.-J., 261Lee, S.S., 40Legrain, P., 196Lehr, S., 66Lehrke, M., 70Leibowitz, M.D., 41Leiss, O., 39Lelliott, C.J., 123

376 Index

Leloup, C., 94Lemieux, S., 165Lentz, J.S., 28, 43Lenzen, S., 94Leone, T.C., 123Leptin, 12, 43, 66, 68, 139, 144, 145, 198

role of, 66Leptos, K.C., 192Lescuyer, P., 187, 188Levine, D.M., 286Lewis, G.F., 43, 343Ley, R.E., 172Leyva, F., 68Li, H., 192Li, L., 253Li, R.X., 200Li, W., 243, 247Li, X., 230Li, Y., 114Li, Z., 166Li, Z.Z., 34Liesa, M., 123Lin, E., 342Lin, J., 123Lin, J.H., 145–147Lin, Y., 253Lindén, D., 162Lingwood, D., 303–305, 309Lipid induced toxicity

deleterious effects of, 10Lipid membrane, 228, 300, 301, 303, 304, 308,

310Lipid metabolism, 29, 30, 34, 41, 44, 66, 72,

73, 75, 116, 118, 163, 197, 201, 224,226, 228, 253, 313, 315

homeostasis of, 33, 34, 40in skeletal muscles, 126mechanism of, 141regulation of, 117

Lipid metabolism, in muscle, 125Lipid spillover, 342–344, 357, 362Lipid-sensing NRs, 37Lipoprotein, 30, 32, 35, 38, 41, 158, 161, 162,

165–167, 227, 300, 301, 312, 314, 315,342, 344, 345, 362, 364

Lipoprotein metabolism, 163, 164Lipoprotein, catabolism of, 164Lipotoxic hypothesis, 125Lipotoxicity, 7, 13, 34, 43, 90, 137, 145, 150,

203Lipotoxicity, in muscle, 125Lipson, K.L., 147Lisacek, F., 190

Listgarten, J., 332Liu, H.B., 192Liu, L., 68Liu, M., 73Liver, 7, 11, 12, 14, 15, 28–30, 32–42, 44, 66,

68, 70, 72, 88, 121, 158, 161, 166, 172,173, 175, 176, 224, 226, 230, 253, 257,258, 267, 269, 282, 283, 289–291, 294,312, 342–344

Liver biopsy, 45Liver X receptors (LXRs), 37–39

cholesterol homeostasis, 37, 38, 93, 176in bile acid metabolism, 37, 176, 291in FA metabolism, 38in glucose metabolism, 38in macrophages, 37, 38LXRs genes, 37

Liver, Kuppfer cells, 125Llaneras, F., 239Lodish, H.F., 117Loftus, T.M., 141, 142, 150Lonard, D.M., 37Long, Y.C., 145Lopez, C.A., 89, 303Lorenzo, C., 63Lorkowski, S., 237Louhivuori, M., 301Lu, Y., 337Lucero, D., 35Ludwig, J., 28, 44Luiken, J.J., 118Lundbak, J.A., 310Luo, Y., 38Lusis, A.J., 86

MMöller, D.E., 251Ma, H., 282Ma, K., 39Ma, Y., 252Ma, Z., 96Maassen, J.A., 230MacBeath, G., 188Macfarlane, G.T., 256Madiraju, S.R., 90Maeda, N., 41, 69, 71, 72Maedler, K., 91, 95Maegawa, H., 113Magkos, F., 166Magnetic resonance imaging (MRI), 43–45Mahadevan, R., 240, 286, 288Maher, A.D., 239Mahley, R.W., 158Maier, B., 95

Index 377

Makishima, M., 38Malet-Martinoa, M., 220Mallick, P., 186, 190Malmstrom, R., 166Malonyl-CoA decarboxylase (MCD), 141Mammalian target of rapamycin (mTOR), 97,

148Mandard, S., 173Mandarino, L.J., 116, 119Mangelsdorf, D.J., 37–39Mann, M., 188, 189, 199Maranas, C.D., 282Marc, J., 64Marchesini, G., 29, 166Mari, A., 89Marin, S., 238, 240, 242Marrero, J.A., 29Marrink, S.J., 301, 303, 305Marsh, B.J., 97Marsh, D., 309Martínez de Morentin, P.B., 144Martin, F.P., 176Martin, T.L., 144Martins, L., 148Masini, M., 97Maslowski, K.M., 177Mass spectrometry (MS), 186, 190, 194, 204,

217, 243Mateo Anson, N., 266Mathews, C., 282Matrix-assisted laser desorption/ionisation

(MALDI), 186, 189, 190, 216Matsuoka, Y., 238, 240Matsuzawa, Y., 65Matteoni, C.A., 28, 29, 44Matthiesen, R., 187, 189, 190, 192Matveyenko, A.V., 96Mayer, J., 149Mayerson, A.B., 41McCarthy, D.J., 326, 333McClain, C.J., 46McCrimmon, R.J., 143, 145McCullough, A.J., 43, 166McGarry, J.D., 117McGillicuddy, F.C., 71McKenna, N.J., 37Mckusick, V.A., 291Medina-Gomez, G., 138Meier, J.J., 88Meijer Twh, K.J., 292Membrez, M., 174Meng, X., 261Menshikova, E.V., 123

Mertens, I., 70Meselhy, M.R., 261Metabolic Analysis Tool (iMAT), 282, 286–289Metabolic flexibility, 119–121, 204Metabolic networks, 178, 238–240Metabolic phenotypic analysis (MPA), 292,

294Metabolic Syndrome (MetS), 3, 4, 6, 9, 44,

63–65, 68–70, 72, 86, 88, 90, 93, 97, 99,100, 116, 138, 224, 246, 247, 251, 252,260, 270, 303, 308, 311, 315, 341–344

metabolic biomarkers of, 230pathogenesis of, 27, 28, 37, 64, 252treatment of, 41, 46, 72

Metabolomics, 178, 186, 213–217, 219, 220,222, 231, 238, 247, 269, 291, 320, 329

Metallo, C.M., 238, 240, 241Metalloproteases (MMPs), 13Metformin (N,N-dimethylimidodicarbonimidic

diamide hydrochloride)beneficial effect of, 73

Metz, T.O., 198Michael, M.D., 88Microsomal transfer protein (MTP), 35, 36,

161Midtvedt, T., 176Milbury, P.E., 259, 269Miller Dm, T.S., 292Miller, J.C., 140Miller, M., 32, 33Miller, N.E., 39Miller, T.L, 255Mingrone, G., 121Minokoshi, Y., 68, 141, 143, 144, 150Misra, P., 73Mitochondrial dysfunction, 36, 65, 86, 94, 121,

123, 125, 126, 199, 229, 230Mitogen-activated protein kinases (MAPKs),

113Mittendorfer, B., 33Mlinar, B., 64Moco, S., 219Model Building Algorithm (MBA), 282, 283,

289–292Mogensen, M., 122Mohamed-Ali, V., 71Molecular dynamics simulation, 228, 300, 304,

306, 310, 312Molly, K., 256Monticelli, L., 303Moore, P.C., 90, 91Mootha, V.K., 119, 122, 199Moreno-Sanchez, R., 239

378 Index

Morgan, K., 140, 149Mori, H., 149Mori, M., 145–147Morino, K., 121Moro, C., 118Morton, G.J., 138, 139Mostertz, W., 323Mouritsen, O.G., 300Mozaffarian, D., 64, 65Muccioli, G.G., 177, 178Mueller, L.N., 192Mulquiney, P.J., 282Multi-way experimental design, 320, 322, 323,

329, 330, 333, 334, 337, 338Multidimensional protein identification

technology (MudPIT), 189Muoio, D.M., 95Murtola, T., 301, 302, 314Muscelli, E., 342Muscle, 7, 11, 14, 15, 36, 42, 72, 113–116,

118–125, 144, 199, 224, 230, 294, 342,344

Muse, E.D., 70Musso, G., 29Musunuru, K., 29Myers, M.G., 66Myers, R.P., 45

NNakahara, M., 39Nakamuta, M., 34, 36, 41Namikawa, C., 36Nanjo, F., 261Natsume, M., 259Navarro, P., 193Nedergaard, J., 144Neels, J.G., 11Nemeth, K., 258Nesbitt, P.D., 259Nestel, P.J., 39Nesvizhskii, A.I., 187, 190Nettleton, J.A., 252Neumann, S., 221Neuschwander-Tetri, B.A., 46, 166Newberry, E.P., 33Newgard, C.B., 95, 225Newsholme, P., 94Neyrinck, A.M., 75Ng, S.K., 332Nguyen, M.T., 114, 124Nickerson, J.G., 117Niemann-Pick C1-like 1 (NPC1L1), 38Niemelä, P.S., 306

Nikerel, I.E., 239Nikkilä, J., 323Nilsson, A.C., 75, 138Nogi, T., 309Noh, K., 244Nolan, J.J., 113Nolte, R.T., 40Nonalcoholic fatty liver disease (NAFLD), 14,

28, 29, 32–37, 40–46, 166, 203, 227pathogenesis of, 42treatment of, 44, 46

Nonalcoholic steatohepatitis (NASH), 28, 36,41–46

prevalence of, 44Norbeck, A.D., 189Nordlund, E., 267Nuclear magnetic resonance (NMR), 217, 220,

222, 224, 243, 260Nuclear receptors (NRs), 36Nurmi, T., 268Nuutila, P., 111Nygren, H., 219

OO’Malley, B.W., 37O’Rahilly, S., 138O’Rourke, R.W., 71Oberhardt, M.A., 282Obese non-diabetic vs. lean individuals, 88Obesity, 3, 6, 7, 9–15, 30, 41–44, 63–66,

68–73, 75, 95, 112, 113, 115, 118–124,138, 140, 144, 145, 147–149, 157,166, 172–174, 176–178, 196, 198, 199,201–203, 214, 224–231, 342

prevalence of, 6, 138Obesogenic environment, 6Obici, S., 142, 149, 150Oh, M.K., 44Okamoto, Y., 75Okita, M., 46Olefsky, J.M., 11, 12, 124Oliver, W.R., 41Ollila, O.H.S., 310, 311Ollila, S., 310Olofsson, C.S., 91Olofsson, S.O., 161Olthof, M.R., 267Olufadi, R., 28Omics data, 320, 322–328, 330, 332–338Onate, S.A., 37Ong, S.E., 191Oprescu, A.I., 90Ordinary differential equations (ODE) system,

245

Index 379

Orešic, M., 226, 320Oresic, M., 237Orth, J.D., 239, 240Ortqvist, E., 99Orvall, M., 226Osei-Hyiaman, D., 177Otte, K., 38Ouchi, N., 68, 69, 75Ouguerram, K., 167Oxidative stress, 36, 42, 43, 72, 90, 94, 199,

214, 229, 230, 251, 294Oyadomari, S., 145–147Ozcan, L., 147, 148, 150Ozcan, U., 36, 71, 149

PPól, J., 216Pajvani, U.B., 69, 73Palagi, P.M., 192Palmblad, M., 189Palsdottir, H., 309Palsson, B.O., 240, 282, 285, 286, 294Pan, W., 328Panchaud, A., 191, 193, 194Pancreas-duodenum homeobox-1 (Pdx-1), 91Pancreatic beta cell, functions of, 86, 99, 100,

198, 199Paolisso, G., 94, 230Papin, J.A., 294Paraventricular nucleus (PVH), 138, 139, 141,

143Parkhomenko, E., 336Parks, D.J., 38Parks, E.J., 33Parton, D.L., 310Pastucha, D., 342Patel, C., 70Patel, L., 70, 75Patsouris, D., 125Pattern recognition receptor, 174Patterson, B.W., 164, 165Patti, M.E., 119, 121, 122Paul Lee, W.N., 238, 240, 243Pawlikowska, P., 123Pealvo, J., 256Pedersen, B.K., 115Peet, D.J., 37Pende, M., 114Peng, J., 190Pennuto, M., 147Pentose-phosphate pathway, 231, 242Peppercorn, M.A., 267Peptide mass sequencing (PMS), 189

Peptide match score summation (PMSS), 192Perez-Perez, R., 197Peripheral energy homeostasis

defects in, 4Perkins, D.N., 189, 190Peroxisome proliferator-activated receptor

(PPARS), 37as fatty acid sensors, 40isoforms of, 40

PPAR-α, 40, 42, 199, 202PPAR-β, 40, 41PPAR-δ, 40, 41PPAR-γ, 40, 41

Petersen, K.F., 32, 33, 72, 119, 121Petta, S., 43Pettersson, J., 260Peyot, M.L., 93, 94Pfeiffer, A.F.H., 252Phenolic acids, 253, 258–260, 266–268Philipson, L.H., 230Phillips, J.C., 303Phosphatidylinositol 3-kinase (PI3K), 113Phosphoenolpyruvate carboxykinase (PEPCK),

30Phosphofructokinase (PFK), 116Pi, J., 94Pich, S., 121Pico, J., 239Pietiläinen, K., 224, 227, 228, 306Pietilainen, K.H., 11Pigeon, E., 342Pineda, T.I., 39Pirola, L., 113Pittas, A.G., 72Plasminogen activator inhibitor 1 (PAI-1)

thrombosis, 70Plum, L., 138Plumb, G.W., 266Pocai, A., 140, 149Poitout, V., 90, 94Pollin, T.I., 33Polyunsaturated fatty acids (PUFAs), 34, 308Pontiroli, A.E., 98Pospisilik, J.A., 123Postic, C., 34Powell, E.E., 28Poynard, T., 45Pratt, J.M., 190Prawitt, J., 176Pre-diabetes, 64Prendergast, G.C., 292Prentki, M., 90, 342Press, W., 245

380 Index

Preston, A.M., 98Priebe, M.G., 252Prieur, X., 12Primary hyperinsulinaemia, 4Principal Component Analysis (PCA), 325,

327, 328, 330, 335Prior, R.L., 267Proanthocyanidin, 260, 261, 265, 266Proopiomelanocortin (POMC), 139, 145, 149Protein abundance indices (PAIs), 192Protein kinase A (PKA), 34Proteomics, 178, 186–188, 190, 192–194, 196,

197, 199–203, 247, 294, 320Proulx, K., 148Psychogios, N., 222Ptacek, J., 188Pullinger, C.R., 35Pyruvate dehydrogenase (PDH), 116

QQatanani, M., 70, 230Qi, D., 96Qi, J., 142Qi, K., 140Qi, L., 75Qiao, L.Y., 114Qin, J., 172Quantum mechanics (QM), 301Quek, L.E., 245Quinn, C.E., 72Qvigstad, E., 99

RRabe, K., 66Rabinowitz, J.D., 97Rabot, S., 173, 174Radtke, M., 99Raftos, J.E., 239Rahmouni, K., 68Rajilic-Stojanovic, M., 257Ralf, J.M., 221Ramadurai, S., 310Rand, R.P., 308Randle, P.J., 30, 226Rao, M.S., 230Rao, P.V., 200Rapoport, S.I., 140Rappsilber, J., 192Rashid, S., 158Raymond, F., 188Reactive oxygen species (ROS), 13, 36, 125,

230Reasner, C.A., 72Reaven, G.M., 88, 226

Rechner, A.R., 259Reddy, J.K., 40, 230Reid, B.M., 44Reigstad, C.S., 174Reilly, M.P., 70Reimann, F., 176Reinhardt, C., 171Repa, J.J., 37, 38Resistin, 7, 69, 124, 139, 198

function of, 70in macrophages, 70inhibitory role of, 70

Riaz, S., 202Ribon, V., 41Righetti, P.G., 189Rinella, M.E., 29, 32Riserus, U., 41Risselada, H.J., 305Ritov, V.B., 121, 122Rizki, G., 29, 32Robbins, R.D., 95Roberts, M.S., 259Robertson, R.P., 90, 94, 95Rocha, V.Z., 71Roden, M., 30, 86Rodriguez-Prados, J.C., 239, 241Rog, T., 300, 305Romeo, S., 44Romero, P., 282Ron, D., 145–147Rondini, L., 266Rondinone, C.M., 227Ronti, T., 66, 68, 70Roowi, S., 261Rosen, P., 230Ross, P.L., 191Rother, K.I., 98Rothman, D.L., 115, 116Rubio-Aliaga, I., 203Rudel, L.L., 161Ruderman, N.B., 138, 141, 142Ruhl, C.E., 44Rumney, C.J., 255Rupnick, M.A., 12Ruppin, E., 239Rutti, S., 93Ryder, J.W., 112

SSaadeh, S., 44Saberi, M., 174Sadee, W., 291Saier, M.H., Jr., 291

Index 381

Saisho, Y., 88Sako, Y., 99Salek, R.M., 324Sampaio, J.L., 303Sampson, M.J., 118Samuel, B.S., 177Samuel, V.T., 29Sanchez, J.C., 197, 202Sander, G.E., 72Sanders, S.L., 192Sano, H., 114Sanyal, A.J., 29, 35, 36, 41, 44–46, 227Sarafidis, P.A., 72, 138Satoh, H., 70Sauer, U., 238Savage, D.B., 41, 70, 227Savkur, R.S., 39, 40Sawai, Y., 253, 259Scalbert, A., 258, 266Schaffer, J.E., 117Schapansky, J., 147Schattenberg, J.M., 29, 32Scheline, R.R., 261Schellenberger, J., 286Schena, M., 188Schenk, S., 113, 124Scherer, P.E., 65, 69, 73, 198Scherl, A., 194Scheuner, D., 98Schilling, C.H., 222, 240, 286, 288Schlatzer, D.M., 200Schmidt, A., 191Schmidt, M., 291Schnell, S., 343Schoenfield, L.J., 39Schonfeld, P., 230Schoonjans, K., 40Schrauwen-Hinderling, V.B., 119, 123Schreiber, S.L., 188Schrimpe-Rutledge, A.C., 199Schroder, M., 71Schuler, M., 123Schuster, S., 239, 240, 286Schwieterman, W., 117Schwudke, D., 219Schymanski, E.L., 221Seeram, N.P., 253, 259Segre, D., 285Selivanov, V.A., 238, 240, 241, 243–245Selma, M.V., 253Semple, R.K., 69Semplici, F., 91Seo, D.M., 324, 337

Serkova, N.J., 225Serotonin, 175Shah, A., 40Shah, O.J., 114Shaheen, A.A., 45Sharma, N.K., 147Shaw, D.E., 301Shaw, R.J., 73Shepherd, J., 39Shi, H., 41Shih, D.M., 39Shimano, H., 34Shimizu, K., 238, 240Shimomura, I., 34Shklyaev, S., 42Shlomi, T., 222, 282, 285, 286, 294Shmueli, O., 291Shotgun approach, 219Shulman, A.I., 37Shulman, G.I., 33, 112, 114Sierra-Honigmann, M.R., 68Silva, R.M., 147Simoneau, J.A., 118–121Simons, K., 303, 304Sinal, C.J., 39, 176Singh, L.P., 201Single-cell mass cytometry, 195Single-nucleotide polymorphisms (SNPs), 32Slot Van’T, G., 265Smilde, A.K., 334Smit, B., 301, 303Smith, C.A., 221Smith, C.E., 252Smith, L., 291Smyth, G., 333Smyth, G.K., 326, 333Sohda, T., 40Song, B., 147Sonoda, J., 123Sorensen, A., 141Sorensen, L.P., 167Soriano, F.X., 123Sotgia, F., 292Sozio, M., 34, 36Spalding, K.L., 10Spiegelman, B.M., 40Spranger, J., 95Sprecher, D.L, 41Spruijt-Metz, D., 75Srour, O., 245Stable-isotope dilution (SID), 191Staehr, P., 343Staels, B., 40

382 Index

Stalmach, A., 261Stannard, S.R., 342Starkey, J.M., 202Statistical analysis, 222, 245, 322, 324, 334,

338Stauber, R.E., 45Stefan, N., 69Steffensen, K.R., 37Stenson, B.M., 38Step-by-step algorithm (SBSA) model, 345Stephanopoulos, G., 239Stephens, J.M., 71Stephenson, J.L., Jr., 189Steppan, C.M., 69, 70Sterol regulatory element binding proteins

(SREBPs), 33, 34Stillemark, P., 161Stillemark-Billton, P., 161Stote, K.S., 253Stoupi, S., 265Strissel, K.J., 71Stump, C.S., 124Sturek, J.M., 93Subramanian, A., 329Suganami, T., 65Summers, S.A., 13Sumner, L.W., 32, 221Sundaram, M., 32Sunny, N.E., 227Sunyaev, S., 189Superoxide dismutase enzymes (SOD), 94Surinova, S., 188Suss, C., 198Suvitaival, T., 337Swann, J.R., 176, 177Syka, J.E., 188, 191Syndrome X, 64Sysi-Aho, M., 324, 333, 336, 337Systems biology, 3, 175, 178, 186, 203, 204,

239, 320, 338Szmitko, P.E., 69

TTabb, D.L., 189Tabernero, M., 255, 256Tai, F., 328Takagaki, A., 261Takahashi, M., 68Takata, Y., 41Talchai, C., 99Tamada M.S.M., 292Tamura, S., 34Tan, P.-N., 328

Tanaka, T., 41Tanaka, Y., 95Tang, Q.Q., 10, 147Tangier disease, 93Taniguchi, C.M., 113Targher, G., 166Taskinen, M.R., 157, 158, 162, 166, 167Taube, A., 113Taylor, C.A., 64Taylor, T.D., 257Teli, M.R., 28Terämä, E., 311Teusink, B., 239Theodoridis, G.A., 217, 219Theodorou, G., 70Thiazolidinediones (TZDs), 40

beneficial effects of, 72in T2DM patients, 41, 72side effects of, 72, 73

Thiebaud, D., 116Thiele, I., 240Thomas, C., 39, 176Thompson, C.B., 292Thong, F.S., 114Thrush, A.B., 118Tibshirani, R., 328, 329Tilton, R.G., 199Toledo, F.G., 121, 123Tonooka, N., 94Tontonoz, P., 38–40Torti, F.M., 71Towle, H.C., 32, 34Tracer studies, 112Trawick, J.D., 222Trayhurn, P., 227Treatment of

obesity with diabetes, 15Tremblay, F., 228Triacylglycerols hydrolysis, 197Tricarboxylic acid (TCA) cycle�see also Krebs

cycle, 119Triglycerides (TGs), 28, 312Trim, P.J., 216Trimethylamines (TMA), 176Tripathi, A., 337Triple-quadrupole (QqQ) mass spectrometer,

218Trygg, J., 328, 336Tryptophan metabolism, 175Tuberous sclerosis complex (TSC), 149Tucker, K.L., 252Tulenko, T.N., 32Tumour necrosis factor α (TNFα), 7, 71, 124

Index 383

Turnbaugh, P.J., 171, 172, 174, 258Turner, N., 119Turrens, J.F., 94Type 1 diabetes mellitus (T1DM), 30, 98, 320,

337Type 2 diabetes mellitus (T2DM), 3, 4,

30, 42, 43, 63–65, 68, 69, 71–73,75, 86, 98, 112, 113, 115, 116,118–122, 124, 138, 158, 162, 166, 167,198–200, 224, 230, 251, 320, 327,335, 341

UUm, S.H., 114Unfolded protein response (UPR), 36, 98, 146Unger, R.H., 7, 29, 65Uribe, A., 175Urizar, N.L., 39

VVacca, M., 39Vaitheesvaran, B., 247van den, B.T., 149van Gunsteren, W.F., 302Vander Heiden, M.G., 292Vapnik, V., 328Varela, L., 148Varghese, S.A., 201Varma, A., 285Vattulainen, I., 300, 310–312Velagapudi, V.R., 172, 175Venema, K., 256Verchere, C.B., 96Vergeer, M., 93Very low density lipoprotein (VLDL),

30, 32, 35, 38, 39, 41, 42, 158,161, 162, 164–167, 172, 176, 224,226, 231

assembly of, 32, 35, 161catabolism of, 158impaired secretion of, 36overproduction of, 32regulators of, 161, 162synthesis of, 35

Verzelloni, E., 253Vestergaard, H., 116Vianna, C.R., 123Vidal-Puig, 138Vidal-Puig, A., 5, 7, 138Vijay-Kumar, M., 174Villarreal-Molina, M.T., 93Viollet, B., 145Virtue, S., 5Visser, M., 252

Vitaglione, P., 268Vizan, P., 242VLDL–triglyceride metabolism, 164Vo, T.D., 282von Eckardstein, A., 93Von, B.K., 39Voth, G.A., 300, 301Vrieze, A., 213

WWagner, M., 38, 39Wajchenberg, B.L., 68Waki, H., 68, 69Walder, K., 122Wall, R., 257Wallace, D.C., 199Wallace, J.M., 41Walle, T., 258Walter, P., 145–147Wang, A.P., 68, 72Wang, H., 38, 71Wang, L., 39, 329Wang, P., 203Wang, Q.M., 201Wang, R., 149Wang, T.J., 228Wang, Y., 32, 39, 201, 226Wang, Y.X., 41, 123Wang, Z., 176Wang, Z.V., 73Wanless, I.R., 28, 43Ward, P.S., 292Washburn, M.P., 189Watada, H., 96Watanabe, M., 39, 176Waterhouse, A.L., 269Watt, M.J., 118Way, J.M., 41Webb-Robertson, B.-J.M., 334, 337Wei, Y., 36Weickert, M.O., 252Weigert, C., 95Weinberg, R.A., 292Weir, G.C., 99Wellen, K.E., 71West, M., 320, 336Westerbacka, J., 32, 227Westerhuis, J., 329Westermark, G.T., 96Westermark, P., 96White adipose tissue, 177, 227White, E., 97White, M.F., 112, 114

384 Index

Whiting, D.R., 86Whittle, A.J., 144Wiback, S.J., 282, 285Wiechert, W., 243–245Wikoff, W.R., 175Wilander, E., 96Williams, K.J., 162Willy, P.J., 37Wilm, M., 189Wilson-Fritch, L., 73Wishart, D.S., 222, 258, 291Woerle, H.J., 112Wojtczak, L., 230Wolcott-Rallison syndrome, 98Wold, S., 328, 336Wolf, S., 221Wolfe, R.R., 33Wolfgang, M.J., 142, 150Wolfinger, R., 332Wolfrum, C., 34Wollscheid, B., 194, 195Won, J.C., 148, 150Woods, S.C., 148Wopereis, S., 227Wostmann, B.S., 176Wredenberg, A., 123Wright, K.S., 114Wu, C., 216Wu, C.C., 191Wu, C.Z., 342Wu, M.C., 330Wu, Z., 41Wyne, K.L., 65

XXenobiotic metabolism, 175Xenobiotics, 247Xia, J., 222Xie, M., 142Xu, A., 42Xu, H., 71Xu, J., 172, 247Xu, Y., 221Xue, B., 144

YYamauchi, T., 68, 69Yan, Q., 291Yanai, I., 286, 291Yang, H., 71Yang, J.C., 149Yang, L., 145Yang, L.V., 227Yannakoulia, M., 75Yanting, W., 302Yao, Z., 32Yeagle, P.L., 303Yetukuri, L., 301, 312, 313, 335Yki-Jarvinen, H., 115, 224Yoshida, K., 173You, M., 41, 42Youssef, W., 166Yu, C., 118Yuan, M., 114Yusta, B., 147

ZZahorska-Markiewicz, B., 252Zamboni, N., 238, 245Zeigerer, A., 114Zelcer, N., 39Zhang, D., 202Zhang, G.F., 247Zhang, H., 92, 93Zhang, X., 147, 148, 150Zhang, Y., 38–40, 66Zhao, Z., 258Zhen, Y., 189Zhou, G., 73Zhou, H., 198Zhou, J., 33, 38Zhou, L., 73Zick, Y., 113Zierath, J.R., 115, 145Zimmet, P., 68, 157Zoltowska, M., 32Zraika, S., 96Zubarev, R.A., 189Zucker diabetic fatty rat, 95Zur, H., 294