Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in...

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Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne, Da Young Oh, Roman Sasik, Simon Schenk, Ai Chen, Heekyung Chung, Anne Murphy, Steven M. Watkins, Oswald Quehenberger, Randall S. Johnson, Jerrold M. Olefsky Cell Volume 157, Issue 6, Pages 1339-1352 (June 2014) DOI: 10.1016/j.cell.2014.05.012 Copyright © 2014 Elsevier Inc. Terms and Conditions

Transcript of Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in...

Page 1: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity 

Yun Sok Lee, Jung-whan Kim, Olivia Osborne, Da Young Oh, Roman Sasik, Simon Schenk, Ai Chen, Heekyung Chung, Anne Murphy, Steven M. Watkins, Oswald Quehenberger, Randall S. Johnson, Jerrold M. Olefsky 

Cell Volume 157, Issue 6, Pages 1339-1352 (June 2014)

DOI: 10.1016/j.cell.2014.05.012

Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 2: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 1

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 3: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 2

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 4: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 3

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 5: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 4

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 6: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 5

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 7: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 6

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 8: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure 7

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 9: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure S1

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 10: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure S2

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 11: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure S3

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 12: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure S4

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 13: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Figure S5

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions

Page 14: Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity Yun Sok Lee, Jung-whan Kim, Olivia Osborne,

Cell 2014 157, 1339-1352DOI: (10.1016/j.cell.2014.05.012) Copyright © 2014 Elsevier Inc. Terms and Conditions