Hammett plots in the world of enzymes

Hammett plots in the world of enzymesErika Aoyama and Megan Browning

Figure 1: A Hammett plot from Louis Hammetts original 1935 paper in which he described Hammett plots. Reference: Hammett, L. P. Chem. Rev. 1935, 17 (1), 125136.

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(sigma)References: Hammett, L. P. Chem. Rev. 1935, 17 (1), 125136. Eric V. Anslyn; Dennis A. Dougherty. Modern Physical Organic Chemistry; University Science Books, 2006.

Hammett plots and (rho)References: Hammett, L. P. Chem. Rev. 1935, 17 (1), 125136. Eric V. Anslyn; Dennis A. Dougherty. Modern Physical Organic Chemistry; University Science Books, 2006.

In general, if:>0, negative charge is building (or positive charge is decreasing)>1: new reaction is more sensitive to substituents than benzoic acid reference reaction0