Gyermekkori non-Hodgkin lymphoma …...aplastic anemia Hypercellular bone marrow Hypercellular bone...

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Hematological investigations Monika Csóka, MD, PhD Dániel Erdélyi MD, PhD Judit Müller MD, PhD

Transcript of Gyermekkori non-Hodgkin lymphoma …...aplastic anemia Hypercellular bone marrow Hypercellular bone...

Page 1: Gyermekkori non-Hodgkin lymphoma …...aplastic anemia Hypercellular bone marrow Hypercellular bone marrow Hypercellular bone marrow Leukemias in children 3-5% 0% 10-15% 80-85% ALL

Hematological investigations

Monika Csóka, MD, PhD

Dániel Erdélyi MD, PhD

Judit Müller MD, PhD

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CBC

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WBC

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Viral infection

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Bacteriral infection

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Eosinophilia

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2-3 μm

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Thrombocytes

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Thrombocytes

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Thrombocytosis

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Thrombocyopenia

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Bone marrow

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Bone marrow

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Csontvelői mintavétel

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Evolution of red and yellow marrow by the age

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Bone Marrow

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Normal bone marrow

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Normal bone marrow

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Inappropriate BM function

aplastic anemia

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Hypercellular bone marrow

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Hypercellular bone marrow

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Leukemias in children

0%3-5%10-15%

80-85%

ALL

AML

CML

CLL

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ALL - morphology

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L1 L2

ALL - morphology

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L3

ALL - morphology

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ALL - immunology

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ALL - immunology

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AML

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AML – morpholgy „FAB”

M0: minimálisan differenciált mieloblasztos

M1: mieloblasztos granulocita érés nélkül

M2: mieloblasztos granulocita éréssel

M3: promielocitás

M4: mielomonocitás

M4eo: mielomonocitás csv-i eozinofíliával

M5: monoblasztos v. monocitás

M6: eritroid

M7: megakarioblasztos

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AML – morpholgy „FAB”

M0: Undifferentiated myeloblastic

M1: Myeloblastic withut maturation

M2: Myeloblastic with maturation

M3: Promyelocytic

M4: Myelomonocytic

M4eo: Myelomonocytic with eosinophilia

M5: Monocytic

M6: Erythroid

M7: Megakaryoblastic

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AML

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AML

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AML

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CML

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karyotyping

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Genetics

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Genetics - FISH

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Lumbar puncture

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Lumbar puncture

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Complications of Lp

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Composition of CSF

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Viral meningitis

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Bacterial meningitis

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Bacterial meningitis

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Cluster of tumorcells (MBL)

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