Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are...

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Glycolysis

Transcript of Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are...

Page 1: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Glycolysis

Page 2: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 3: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

The three steps

Glucose + 2Pi +2ADP +2NAD

2Pyruvate + 2ATP +2NADH +2H+ +2H2O

Page 4: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 5: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Glucose to Glucose 6 phosphate

Page 6: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Hexokinase

Page 7: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

G6P to F6P

Phosphohexose isomerase

Mg++

ΔG’O=1.7 kJ/mol

Page 8: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 9: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

ΔG’o= -14.2 KJ/mol

F6P to F1,6, BP

Page 10: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

F1,6BP to DHAP & G3P

ΔG’O = 23.8kJ/mol

Page 11: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

DHAP & GAP

Page 12: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 13: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

GAP to 1,3-BPG

ΔG’O = 6.3kJ/mol

Page 14: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

1,3-BPG to 3-PG

ΔG’O = -18.5kJ/mol

Page 15: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

3’PG to 2’PG

Rearrangement shifts PO4 position from C3 to C2.

Page 16: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

2PG to PEP

Enol PO4

Page 17: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

PEP to Pyruvate

Page 18: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 19: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Thermodynamics

Page 20: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Uses of Pyruvate

Regeneration of NAD

Page 21: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Pyruvate to ethanol

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Pyruvate to lactate

Page 23: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Recycling NAD

Page 24: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 25: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

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Page 26: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Galactose

Page 27: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 28: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 29: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that
Page 30: Glycolysis - Biolympiads · Glycolysis can proceed only if the AG values of all reactions are negative. The small positive AG values of three of the above reactions indicate that

Glycogen to glucose (starvation)

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Ag Arx Simeioseis

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Aton Ag. Symeon Tom 2

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