BRUDYLABVADEMECUM 2018

Food Supplements enriched with Tridocosahexaenoina-AOX®

COMPOSITION 1 capsule %RDA*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 350 -20:5ω3, EPA (mg) 42,5 -22:5ω3, DPA (mg) 30 -VitaminsVitamin C (mg) 80 100Vitamin E (mg α-ET) 12 100MineralsZinc (mg) 10 100Copper (mg) 1 100Other nutrientsLutein (mg) 5 -Zeaxanthin (mg) 1,4 -

1 capsule/day = 350 mg DHA

B R U D Y M A C U L ACOMPOSITION 1 cap. %RI* 2 cap. %RI*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 500 - 1000 -20:5ω3, EPA (mg) 61 - 122 -22:5ω3, DPA (mg) 42 - 84 -MineralsZinc (mg) 5 50 10 100Selenium (µg) 27,5 50 55 100Copper (mg) 0,5 50 1 100Manganese (mg) 1 50 2 100Other nutrientsGlutathione (mg) 1 - 2 -

2 capsules/day = 1000 mg DHA

B R U D Y I T I S

Night Eyelid application

COMPOSITIONDecongestant-soothingDHA TriglycerideMoisturizersHyaluronic acidAloe Vera leaf juiceSeed oils: olive, avocado, grapefruit, sesame, grape, geranium and Tea tree. Other Components(See the complete INCI formulationin the box)

B R U D Y D E R MD RY E Y E

B R U D Y N E NE M U L S I Ó N **

1 sachet/day = 1 g DHA

COMPOSITION 1 sachet (4,7g) 100gProteins (g) 0 0Carbon Hydrates (g) 0,94 20from which fructose (g) 0,46 9,8Fats (g) 3,63 77,3from which:Saturated fatty acids (g) 0,3 6,46Monounsaturated fatty acids (g) 1,68 35,8Polyunsaturated fatty acids (g) 1,64 3522:6ω3, DHA (g) 1 21,322:5ω3, DPA (g) 0,15 3,220:5ω3, EPA (g) 0,09 1,9Salt/sodium (g) 0 0

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BRUDYLABVADEMECUM 2018

*RDA = Recommended daily allowances / *RI = Reference Intake **Dietetic Food for Special Medical Purposes

B R U D Y S E CCOMPOSITION 1 cap. %RDA* 3 cap. %RDA*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 350 - 1050 -20:5ω3, EPA (mg) 42,5 - 127,5 -22:5ω3, DPA (mg) 30 - 90 -VitaminsVitamin A (µg ER) 133,33 16,66 400 50Vitamina C (mg) 26,7 33 80 100Vitamina E (mg α-ET) 4 33 12 100MineralsZinc (mg) 1,6 16,66 5 50Copper (mg) 0,16 16,66 0,5 50Selenium (µg) 9,17 16,66 27,5 50Manganese (mg) 0,33 16,66 1 50Other nutrientsTyrosine (mg) 10,8 - 32,5 -Cysteine (mg) 5,83 - 17,5 -Glutathione (mg) 2 - 6 -

3 capsules/day = 1050 mg DHA

COMPOSITION 1 cap. 2 cap. 3 cap.Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 350 700 105020:5ω3, EPA (mg) 42 84 12722:5ω3, DPA (mg) 30 60 90

3 capsules/day = 1050 mg DHA

brudyplus

COMPOSITION 1 capsule %RDA*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 250 -20:5ω3, EPA (mg) 31 -22:5ω3, DPA (mg) 22 -VitaminsVitamin A (μg ER) 400 50Other nutrientsFlavonoids (mg) 100 -Lutein (mg) 3 -Zeaxanthin (mg) 0,30 -

1 capsule/day = 250 mg DHA

B R U D Y O P I A

COMPOSITION 1 cap. %RDA* 3 cap. %RDA*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 350 - 1050 -20:5ω3, EPA (mg) 42,5 - 127 -22:5ω3, DPA (mg) 30 - 90 -VitaminsVitamin B1 (mg) 0,37 33 1,1 100Vitamin B2 (mg) 0,47 33 1,4 100Vitamin B3 (mgNE) 5,3 33 16 100Vitamin B6 (mg) 0,47 33 1,4 100Vitamin B9 (µg) 66,7 33 200 100Vitamin B12 (µg) 0,83 33 2,5 100Vitamin C (mg) 26,7 33 80 100Vitamin E (mg α-TE) 4 33 12 100MineralsZinc (mg) 1,66 16,66 5 50Copper (mg) 0,16 16,66 0,5 50Selenium (µg) 9,16 16,66 27,5 50Manganese (mg) 0,33 16,66 1 50Other nutrientsLutein (mg) 3 - 9 -Zeaxanthin (mg) 0,3 - 0,9 -Glutathione (mg) 2 - 6 -

3 capsules/day = 1050 mg DHA

B R U D Y R E T I N A B R U D Y P I OCOMPOSITION 1 cap. 3 cap. %RI*Oil concentrated inOmega-3 fatty acids22:6ω3, DHA (mg) 350 1.050 -20:5ω3, EPA (mg) 42,5 127,5 -22:5ω3, DPA (mg) 30 90 -VitaminsVitamin A (µg ER) 133,33 400 16,7-50Vitamin C (mg) 26,7 80 33-100Vitamin E (mg α-ET) 4 12 33-100Vitamin B1 (mg) 0,36 1,1 33-100Vitamin B2 (mg) 0,46 1,4 33-100Vitamin B3 (mg NE) 5,33 16 33-100Vitamin B6 (mg) 0,46 1,4 33-100Vitamin B9 (µg) 66,7 200 33-100Vitamin B12 (µg) 0,83 2,5 33-100MineralsZinc (mg) 3,33 10 33-100Copper (mg) 0,33 1 33-100Manganese (mg) 0,66 2 33-100Selenium (µg) 18,3 55 33-100Other nutrientsLutein (mg) 3,33 10 -Zeaxanthin (mg) 0,33 1 -Glutathione (mg) 2 6 -Licopene (mg) 2 6 -Q10 Coenzyme (mg) 2 6 -Flavonoids (mg) 16,7 50 -Oleopeuroside (mg) 4 12 -Soya lecithin (mg) 16,7 50 -

3 capsules/day = 1050 mg DHA

Food Supplements enriched with Tridocosahexaenoina-AOX®

*** Authorized use until 3 months of first opening

OCULAR INFLAMMATION Product Content Dose DHA (mg) NC BRUDYITIS 30 capsules 1-2 caps/day 500-1000 179532.8

RETINA AND MACULABRUDYRETINA 30 capsules 1-3 caps/day 350-1050 158369.7BRUDYRETINA 90 capsules 1-3 caps/day 350-1050 160301.2BRUDYMACULA 60 capsules 1-2 caps/day 350-700 158367.3BRUDYNEN Emulsión 30 sachets 1 sachet/day 1000 162570.0

GLAUCOMABRUDYPIO 30 capsules 1-3 caps/day 350-1050 158368.0BRUDYPIO 90 capsules 1-3 caps/day 350-1050 165081.8

MYOPIC RETINOPATHYBRUDYOPIA 30 capsules 1 caps/day 250 158370.3

EYE CARE

OCULAR SURFACEProduct Content Dose DHA (mg) NC BRUDYSEC 30 capsules 1-3 caps/day 350-1050 158371.0BRUDYSEC 90 capsules 1-3 caps/day 350-1050 161522.0BRUDYNEN Emulsión 30 sachets 1 sachet/day 1000 162570.0

SODIUM HYALURONATE ARTIFICIAL TEARS, PRESERVATIVE FREEVISMED 20 monodoses no limit of use 0,18 159578.2VISMED GEL 20 monodoses no limit of use 0,30 159779.3VISMED MULTI*** 10 ml no limit of use 0,18 163806.9BRUDYAL 20 monodoses no limit of use 0,10 167573.6

NIGHT EYELID GEL FOR DRY EYEBRUDYDERM DRY EYE 10 ml For night use -- 180690.1

CARE FOR OCULAR SURFACE AND LIDS

Product Content Dose DHA (mg) NC BRUDYNEN Emulsión 30 sachets 1 sachet/day 1000 162570.0 BRUDYPLUS 90 capsules 1-3 caps/day 350-1050 152783.7

TO OPTIMISE BRAIN FUNCTION AND AMBLYOPIA

DHA HEALTH CLAIMS APPROVED BY THE EUROPEAN COMMISSION

INFORMATION TO USER

Daily amount necessary to obtainthe beneficial effect REGULATION

HEALTH CLAIMS APPROVED BY THE EC

Consultations on EU regulation at: www.eur-lex.europa.eu Search from year and number of the regulation cited in the right column of the table.

DHA intake contributes to normal visual development.

DHA contributes to maintenance of normal vision.

DHA contributes to maintenance of normal brain function.

DHA (and DHA with EPA) contribute to normal function of the heart.

DHA maternal intake contributes to the normal development of the eye of the foetus and breastfed infants.

DHA maternal intake contributes to the normal brain development of the foetus and breastfed infants.

DHA and EPA contribute to the maintenance of normal blood triglyceride levels.

DHA and EPA contribute to the maintenance of normal blood pressure.

Infants up to 12 months 100mg/day

Adults and children between

2 to 18 years, 250mg/day

Pregnant and lactating women 250mg+200mg =

450mg/day

DHA or (DHA+EPA) 2g/day; not to exceed a supplemental daily

intake of 5g of EPA and DHA combined.

DHA or (DHA+EPA) 3g/day; not to exceed a supplemental daily

intake of 5g of EPA and DHA combined.

EU 440; May 6, 2011

EU 432; May 16, 2012 for adults.

EFSA Journal 2014; 12(10):3840 for kids between 2-18 years.

EU 440; May 6, 2011

EU 536; June 11, 2013

BRUDYLAB CLINICAL EXPERIENCETHAT DEMONSTRATES EFFECTIVENESS IN THE HUMAN

DRY EYE 1. Pinazo-Durán MD, et al; Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflammation and immune response mediators in tears from patients with dry eye disorders; Clinical Int Aging 2013; 8:139-148.2. Ribelles A, et al; Ocular Surface and Tear Film Changes in Older Women Working with Computers; BioMed Research International 2015; Article ID 467039.3. Galbis-Estrada C, et al; A metabolomic approach to dry eye disorders. The role of oral supplements with antioxidants and omega 3 fatty acids; Mol Vis. 2015 May 11;21:555-67.4. Zanón-Moreno V, Raga-Cervera J, Sanz-González S, Pinazo-Durán MD; Effects of the nocturnal application of a dermatologic gel-cream containing docosahexaenoic acid and hyaluronic acid on the palpebral and ocular surface integrity. To be sent for publication to J. Optom 2017. 6- Oleñik A, et al; A randomized, double-masked study to evaluate the effect of omega-3 fatty acids supplementation in meibomian gland dysfunction; Clinical Interventions in Aging 2013; 8:1133–38.5. Oleñik A, et al; Benefits of Omega-3 fatty acid dietary supplementation on health-related quality of life in patients with Meibomian Gland Disfunction ;Clinical Ophthalmol 2014; 8:831-836.6. Gatell-Tortajada J, et al; Oral supplementation with a nutraceutical formulation containing omega-3 fatty acids, vitamins, minerals, and antioxidants in a large series of patients with dry eye symptoms: results of a prospective study; Clin Int Aging 2016; 11:571-578.7. Oleñik A, et al; Effectiveness and tolerability of dietary supplementation with a combination of omega-3 polyunsaturated fatty acids and antioxidants in the treatment of dry eye symptoms: results of a prospective study; Clinical Ophthalmology 2014:8 169–176.

DIABETIC RETINOPATHY 8. María Lafuente, et al; Combined intravitreal Ranibizumab and oral supplementation with docosahexaenoic acid and antioxidants for Diabetic Macular Edema: Two-Year Randomized Single-Blind Controlled Trial Results; Retina 2017; 37:37:1277-1286.9. María Elena Rodríguez, et al; Supplementation with Docosahexaenoic Acid in Nonproliferative Diabetic Retinopathy: Prospective Controlled Study of Macular Function by Fundus Microperimetry; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 3, 2017. Already sent for publication to Clinical Ophthalmology 2017. 10. María Lafuente, et al; Intravitreal Ranibizumab combined with docosahexaenoic acid (DHA) dietetic supplementation in diabetic macular edema: 36 months randomized single-blind controlled trial; Communication presented at the XXI Congress of the Spanish Society of Vitreous and Retina, Madrid, Mars 4, 2017. Sent for publication to Journal of Retina 2017.

GLAUCOMA 11. Tellez-Vazquez J, et al; Omega-3 fatty acid supplementation improves dry eye symptoms in patients with glaucoma: results of a prospective multicenter study; Clin Ophthalmol 2016; 10:617-626.12. Galbis-Estrada C, et al; Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral supplement with antioxidants and essential fatty acids; Clin Int Aging 2013;8:711-9.13. Elena Rodríguez-Deferro; Efficacy of antioxidant food supplements in Expholiation Glaucoma patients: six-months randomized, controlled-trial results. Pending to be sent for publication. FERTILITY 14. Martinez-Soto JC, et al; Dietarysupplementation with docosahexaenoic acid (DHA) mproves seminal antioxidant status and decreases sperm DNA fragmentation; Syst Biol Reprod Med. 2016 Oct 28:1-9.15. Martinez-Soto JC; Effect of dietary DHA supplementation on sperm DNA integrity; Fertility & Sterility 2010; 94(4):S235-S236 P-495. 16. Popova A Yu, et al, Experience in the use of docosahexaenoic acid (BrudiPlus) in раtiепts with increased spenn DNA fragmentation index in Acad. V.I. Kulakov Research Center for Obstetrics, Gупесоlоgy and Perinatology; Andrology & Genital Surgery 2015; 16(2): 51-55.

DISLIPEMIAS 17. Domingo P, et al; Effects of docosahexanoic acid on metabolic and fat parameters in HIV-infected patients on cART: A randomized, double-blind, placebo-controlled study; Clinical Nutrition 2017; Pp: 1-8.

EXERCISE-SPORTS 18. JF Guzzman, et al; DHA- rich fish oil improves complex reaction time in female elite soccer players; Journal of Sports Science and Medicine (2011) 10, 301-305.19. J Lopez-Román; Modifications in oxidative damage in consumers of Algatrium® (a unique source of DHA) in a given daily dose; Pending to be sent for publishing.20. Contreras C J, et al; Variation on the oxidative harm in a group of cycling sportsmen after consumption of docosahexaenoic acid at different doses; Doctoral Thesis, San Antonio Catholic University of Murcia, 2014.

CELL CULTURES & ANIMAL EXPERIMENTATION 21. P. Bogdanov, et al; Docosahexaenoic Acid Improves Endogen Antioxidant Defense in Arpe-19 Cells; IOVS, ARVO Journals; May 2008, Vol.49, 5932. doi:22. Mancera P, et al; Natural Docosahexaenoic Acid in the Triglyceride Form Attenuates In Vitro Microglial Activation and Ameliorates Autoimmune Encephalomyelitis in Mice; Nutrients 2017, 9, 681; doi:10.3390/nu9070681.

Decongesting action Tridocosahexaenoina-AOX® (DHA-Triglyceride)

Moisturizing actionSodium Hyaluronate &Aloe Vera leaf juice

• Gel protected from the air • Content 10 ml.• 50 approximate doses• Use on undamaged Eyelid skin.

Do not apply inside the eye.

Eyelid gel with Tridocosahexaenoina-AOX® for night use in the dry eye

B R U D Y D E R MD RY E Y E

Sales at pharmacies, phone 900 12 12 50 and www.brudyshop.comBRUDYLAB C/ Ulises, 108, 2º C. 28043 Madrid. Tel. 91 300 10 14. www.brudylab.comThe information content is exclusively addressed to healthcare professionals

*Zanón–Moreno V, Raga-Cervera J, Sanz-González S, Pinazo-Durán MD; Effects of the nocturnal application of a dermatologic gel-cream containing docosahexaenoic acid and hyaluronic acid on

the palpebral and ocular surface integrity. Sent for publication to J Optometry 2017.

Hydration and decongestion of the skinof the eyelid, of the meibomian glands

and the ocular surface, during sleep,for a better awakening*

MEDICAL NUTRITION SPECIALISTS

2017

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NEW