FluoProbes®FT-QU636A

BTA-2Product Description

Name : BTA-22-(4'-(dimethylamino)phenyl)-6-methyl-benzothiazole

Catalog Number : FP-QU636A 25 mg

Structure : CAS [10205-62-6] C16H16N2SMolecular Weight : MW= 268,38Solubility: EtOH, DMSOAbsorption / Emission : λexc\λem = 356/437nm

Storage: +4°C Protect from light and moisture

Introduction A fluorescent neutral Thioflavin-T derivative that exhibits high affinity for amyloid deposits (Ki = 143 nM for Aβ40) and can cross the blood brain barrier. Displays up to 6-fold higher affinity than ThT. Stains both plaques and neurofibrillary tangles in post mortem Alzheimer’s disease brain.

Directions for use

Guidelines for use Protocol may be found in the literature.

References - Hampf M. et al., A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays,

Analytical Biochemistry, Volume 356, Issue 1, Pages 94-99 (2006) Abstract- Hongying Du et al., Classification structure–activity relationship (CSAR) studies for prediction of genotoxicity of

thiophene derivatives, Toxicology Letters, Volume 177, Issue 1, Pages 10–19 (2008)- Kung HF, et al. Novel stilbenes as probes for amyloid plaques. J Am Chem Soc 123, 12740-1 (2001) - Mathis CA, et al.. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in

brain. Bioorg Med Chem Lett 12, 295-8 (2002)

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FluoProbes®FT-QU636A

Technical and scientific informationRelated products

Thioflavin-T, FP-BS6530 Firefly and Renilla Luciferase Dual Assay Kit (single tube), BE7812

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FluoProbes®BTA-2Product DescriptionBTA-2

IntroductionDirections for useGuidelines for useReferences

Technical and scientific informationRelated products

Ordering information